Toxicity T cell position vaccine of the cell for treating Hepatitis B and the preparing method

A hepatitis B virus, cytotoxic technology, applied in the direction of antiviral agents, pharmaceutical formulations, antibody medical ingredients, etc., can solve the problems of inability to completely remove the virus and poor long-term efficacy

Inactive Publication Date: 2010-11-10
SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
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Problems solved by technology

The treatment drugs for HBV infection currently mainly rely on IFN-α and nucleoside analogs, none of these drugs can completely clear the virus, and the long-term efficacy is poor

Method used

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  • Toxicity T cell position vaccine of the cell for treating Hepatitis B and the preparing method
  • Toxicity T cell position vaccine of the cell for treating Hepatitis B and the preparing method
  • Toxicity T cell position vaccine of the cell for treating Hepatitis B and the preparing method

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Abstract

The invention relates to bio-pharmaceutical engineer technology domain. At present, the therapeutic drugs for HBV infection mainly depend on IFN-Alpha and nucleotide analog, which can not kill virus thoroughly with worse remote therapeutic effect. The invention provides a cytotoxic T cell epitope vaccine for hepatitis B, comprising a fused polypeptide formed by connecting 21 CTL epitopes selectedfrom CTL epitopes data of HBV antigen and two universal epitopes of auxiliary T lymphocyte. Saccharomyces Serevisiae is selected to express the fused antigen and mixes with immunologic adjvant. The said vaccine can activate and enhance the cellular immune response of patient with chronic HBV infection. The vaccine can also promote the immune elimination of HBV, and can be used for treatment of chronic hepatitis B.

Description

Hepatitis B therapeutic cytotoxic T cell epitope vaccine and preparation method thereof Technical field: The invention relates to the technical field of biomedical engineering, and is a hepatitis B therapeutic cytotoxic T cell epitope vaccine and a preparation method thereof. Background technique: Hepatitis B virus (hepatitis Bvirus, HBV) is a hepatotropic DNA virus that is prone to chronic infection after infecting the human body. It is the first cause of liver cirrhosis and primary liver cancer in Southeast Asian countries and regions, including my country. The treatment drugs for HBV infection are currently mainly dependent on IFN-α and nucleoside analogues. None of these drugs can completely eliminate the virus and the long-term efficacy is poor. Therapeutic vaccine is a specific immunotherapy that has emerged in the past decade. Animal and clinical studies have shown that vaccination of this type of vaccine can enhance the cellular immune response of the infected person (...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K39/29A61K39/39A61P1/16A61P31/20C12N15/62
Inventor 陈志辉赵平王路戚中田
Owner SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
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