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Preparation for composition of vitamin and mineral matter
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A preparation process and vitamin technology, which is applied in the directions of drug combinations, active ingredients of heterocyclic compounds, and medical preparations containing active ingredients, etc. It can solve the problems of good stability and other problems, and achieve the effect of simplifying the production process, stable vitamin content and good stability.
Active Publication Date: 2011-07-20
HANGZHOU MINSHENG HEALTHCARE CO LTD
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However, this preparation process is not suitable for tablets, because the coated pellets have a large particle size and are round, and are easily broken after tablet compression, which cannot improve the stability of the composition. The fluidity is too good, and it is not easy to combine with Mix other ingredients in the
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Embodiment 1
[0029]
[0030]
[0031] Preparation Process:
[0032] (1) Vitamin C coating
[0033] ① Take the prescribed amount of vitamin C, tartaric acid and lactose, pulverize them, sieve and mix them evenly;
[0034] ②Coating liquid preparation: Weigh 100g of methacrylic acid / ethyl acrylate (1:1) copolymer aqueous dispersion and 400g of ethyl acrylate / methyl methacrylate (2:1) copolymer aqueous dispersion, and mix with Dilute with water at a ratio of 1:1, mix the two liquids together, and stir at a low speed; weigh 300g of pure water, heat to 70°C, add 9g of Tween 80 (33% aqueous solution), homogenize with a homogenizer, and add monostearin Homogenize 7.5g of acid glyceride for 10-20 minutes, continue to stir with an ordinary mixer until the temperature of the suspension drops below 30°C, pour this solution into the above mixed solution, and continue to stir at a low speed until the coating process is completed;
[0035] ③The above-mentioned drug mixed powder is not placed in the...
Embodiment 2
[0042]
[0043]
[0044] Preparation process: Except that the consumption of the coating liquid is 675g when the vitamin C powder is not coated, the coating liquid prescription, preparation process and tablet production preparation process are the same as in Example 1.
Embodiment 3
[0046]
[0047]
[0048] Preparation process: except that the consumption of the coating liquid is 900 g when the vitamin C powder is not coated, the coating liquid prescription, preparation process and tablet production preparation process are the same as in Example 1.
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Abstract
The invention provides a process for preparing a composition of vitamins and minerals, which contains the following components in each 1,000 tablets: 1 to 5 * 10<6>IU of vitamin A, 0 to 2 grams of beta-carotene, 0.75 to 4 * 10<5>IU of vitamin D, 0 to 30 milligrams of vitamin K, 0.5 to 5 grams of vitamin B1, 0.5 to 5 grams of vitamin B2, 0.25 to 1 gram of vitamin B6, 0.5 to 2 milligrams of vitaminB12, 25 to 100 grams of vitamin C, 0 to 0.4 grams of folic acid, 0 to 30 milligrams of biotin, 5 to 15 grams of vitamin E, 5 to 15 grams of nicotinamide, 2.5 to 10 grams of calcium pantothenate, 0 to50 grams of heavy choline bitartrate, 0 to 100 milligrams of iodine, 0 to 25 grams of L-lysine salt, 0 to 50 grams of inositol, 5 to 10 grams of potassium, 5 to 15 grams of iron, 0.5 to 1 grams of copper, 0 to 50 milligrams of selenium, 0 to 120 grams of magnesium, 0 to 2 grams of manganese, 0.25 to 15 grams of zinc, 0 to 20 milligrams of chromium, 0 to 25 milligrams of molybdenum, 163 to 558 grams of bicalcium phosphate, 0 to 600 grams of calcium carbonate, 50 to 100 grams of starch, 30 to 60 grams of lactose, 100 to 200 grams of microcrystalline cellulose, 20 to 50 grams of dextrin, 15 to 50 grams of cross-linked sodium carboxymethyl cellulose, 0 to 30 grams of low substituted hydroxypropyl cellulose, 8 to 16 grams of tartaric acid, 5 to 20 grams of talcum powder, 8 to 12 grams of superfine silica gel powder, and 6 to 10 grams of magnesium stearate. The process is characterized in that the vitamin C adopts powder coating, and the coating material is methyl acrylate copolymer, preferably a mixture of a methacrylic acid / ethyl acrylate (1 to 1) copolymer and an ethyl acrylate / methyl methacrylate (2 to 1) copolymer, wherien the weight ratio of mixture is between 1 to 4 and 4 to 1. The composition of the vitamins and the minerals has simple preparation process and convenient operation, and can improve the stability of the vitamins.
Description
technical field [0001] The invention belongs to the technical field of medicine and health food, and in particular relates to a preparation technology of a vitamin and mineral composition. Background technique [0002] With the development of the economy and the improvement of residents' income levels, great changes have taken place in people's dietary structure and lifestyle, and people's health concepts have also changed. The health concept of supplementing an appropriate amount of vitamins and minerals every day has been accepted. Accepted by the general public. However, vitamins are a class of compounds that are easily damaged by external conditions such as light, humidity, and heat, and they are quite sensitive to the physical and chemical environments in which they live. Because most vitamins contain unsaturated carbon atoms, double bonds, hydroxyl groups or other chemical structures that are extremely sensitive to chemical reactions, when these chemical structures ar...
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Application Information
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