Use of diterpenoids from Isodon japonica var.galaucocalyx in preparing anti-cancer medicine

A technology of compound and diterpenoids, applied in the field of preparation of anticancer drugs

Inactive Publication Date: 2010-11-10
SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

So far, there are no reports about the anticancer activity of cyanine A, cyanine B, cyanine C, cyanine D, cyanine, cyanhex and cyanine X

Method used

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  • Use of diterpenoids from Isodon japonica var.galaucocalyx in preparing anti-cancer medicine
  • Use of diterpenoids from Isodon japonica var.galaucocalyx in preparing anti-cancer medicine
  • Use of diterpenoids from Isodon japonica var.galaucocalyx in preparing anti-cancer medicine

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Abstract

The present invention relates to technical field of medicine, and relates to the use of diterpenoid compounds of glaucocalyxin A, glaucocalyxin B, glaucocalyxin C, glaucocalyxin D, glaucocalyxin E and glaucocalyxin F in Isodon japonica (Burm f) Hara var glaucocalyx (Max) Hara for preparing anti-cancer medicine. The invention adopts an MTT method for executing cytotoxicity experiment. The result shows that the glaucocalyxin A, glaucocalyxin B, glaucocalyxin C, glaucocalyxin D, glaucocalyxin E and glaucocalyxin F all have remarkable cytotoxicity respectively thereby can be used for preparing the anti-cancer medicine. The invention provides a new source for preparing anti-cancer medicine.

Description

Application of diterpenoids in blue calyx corydalis in preparing anticancer drugs Technical field The present invention relates to the technical field of medicine. The diterpenoid compounds cyanocalyxin, cyanocalyxin, cyanocalyxin, cyanocalyxin, cyanocalyx penetin and cyanocalyxin in blue calyx are used for preparation Use of anti-cancer drugs. Background technique GlaucocalyxinA (RJ01), GlaucocalyxinB (RJ02), GlaucocalyxinC (RJ04), GlaucocalyxinD (RJ03), GlaucocalyxinE ) (RJ05) and GlaucocalyxinF (RJ06) are the whole plant from the Labiatae genus Rabdosiajaponica (Burm.f.) Haravar.glaucocalyx (Maxim.) Hara) Kauritan-type diterpenoids isolated from the kauri [Gui Mingyu, et al. Study on the chemical constituents of blue scented tea vegetable II, Chinese Pharmaceutical Journal, 2000; 35(6): 375; ZhaoBaoXiang (项昭保), HaiShengChen (陈海生), etal.TwonewditerpenoidsfromRabdosiajaponicavar.glaucocalyx, ChineseChemicalLetter2008;19:852-854; (Xiang Zhaobao), Hai Sheng Chen (Chen Haishe...

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Application Information

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Patent Type & AuthorityPatents(China)
IPC IPC(8): A61K31/122A61P35/00
Inventor陈海生项昭保刘建国金永生赵卫权
OwnerSECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY