Methods for treating obesity and obesity related diseases and disorders

A technology of obesity and obesity agents, applied in the fields of medicine, health, diet and nutrition, which can solve the problems of imbalance between nutrient availability and energy consumption, excess adipose tissue, etc.

Inactive Publication Date: 2011-01-05
AMYLIN PHARMA INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

A problem in obese patients is the imbalance between nutrient availability and energy expenditure until excess adipose tissue

Method used

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  • Methods for treating obesity and obesity related diseases and disorders
  • Methods for treating obesity and obesity related diseases and disorders
  • Methods for treating obesity and obesity related diseases and disorders

Examples

Experimental program
Comparison scheme
Effect test

Embodiment approach 1

[0130] Embodiment 1. A method of treating obesity in a patient comprising peripherally administering therapeutically effective amounts of at least two different anti-obesity agents, wherein at least one of the anti-obesity agents is amylin, an amylin analog, or an amylin agonist (i.e., an amylin agent) and another is at least one anti-obesity agent that is leptin, a leptin derivative, or a leptin agonist (i.e., a leptin agent); wherein the patient loses at least 10% of their body weight .

Embodiment approach 2

[0131] Embodiment 2. A method of reducing body weight in a patient comprising peripherally administering therapeutically effective amounts of at least two different anti-obesity agents, wherein at least one of the anti-obesity agents is amylin, an amylin analog, or an amylin agonist , and at least one anti-obesity agent is leptin, a leptin derivative, or a leptin agonist; wherein the anti-obesity agent is administered in an amount effective to reduce the patient's body weight by at least 10%.

Embodiment approach 3

[0132] Embodiment 3. The method of any one of embodiments 1 or 2, wherein said at least one anti-obesity amylin agent is an amylin agonist.

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Abstract

Methods for treating obesity or obesity related disorders are disclosed. These methods include the use of anti-obesity agents directed to the forebrain in combination with anti-obesity agents directed to the hindbrain.

Description

field of invention [0001] The present invention relates to the field of medicine, and in particular to the fields of health, diet and nutrition. The present invention relates to the use of anti-obesity agents. Background of the invention [0002] Obesity and its related disorders are common and serious public health problems in the United States and around the world. Upper body obesity is known to be the strongest risk factor for type 2 diabetes and is a strong risk factor for cardiovascular disease. Obesity is also associated with high blood pressure, atherosclerosis, congestive heart failure, stroke, gallbladder disease, osteoarthritis, sleep apnea, reproductive disorders such as polycystic ovary syndrome, breast, prostate, and colon cancer, and general anesthesia Recognized risk factors for increased incidence of complications (see eg Kopelman, Nature 404:635-43 (2000)). [0003] Obesity shortens lifespan, and obese people suffer from co-morbidities listed above as wel...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K38/22A61K45/06A61P3/00
CPCA61K38/2278A61K31/137A61K38/2264A61K31/35A61K38/22A61K31/155A61P3/00A61P3/04A61K2300/00
Inventor J·D·罗思A·D·巴伦C·安德森
Owner AMYLIN PHARMA INC
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