Polypeptide used for prevention and treatment of acute coronary syndrome and anticoagulation antithrombotic therapy and application thereof

Abstract

The invention relates to a polypeptide used for prevention and treatment of acute coronary syndrome and anticoagulation antithrombotic therapy and application thereof. A sequence of the polypeptide disclosed by the invention is P1 Pro-Ser-Hyp-Gly-Asp-TrpP2 Pro-Ser-Hyp-Gly-Asp-Trp-ArgP3 Pro-Ser-Lys-Gly-Asp-TrpP4 Pro-Ser-Val-Gly-Asp-TrpP5 Pro-Ser-Nva-Gly-Asp-Trp-ArgP6 Pro-Ser-Pro-Gly-Asp-TrpP7 Pro-Ser-Thz-Gly-Asp-Trp, the polypeptide is independently used or combined with aspirin, clopidogrel or heparin, is used for inhibiting platelet aggregation and thrombosis and is taken as an effective ingredient for preparing a medicine used for prevention and treatment of acute coronary syndrome, unstable angina and acute myocardial infarction and intervention therapy of anticoagulation antithrombotic therapy. The polypeptide provided by the invention can be combined with a human blood platelet GPIIb-IIIa receptor, and has the capabilities of blocking blood platelet aggregation induced by adenosine diphosphate, arachidonic acid and thrombin and effectively inhibiting coronary thrombosis and femoral thrombosis.

Description

technical field [0001] The invention belongs to the technical field of medicine preparation, and specifically relates to a polypeptide for preventing and treating acute coronary syndrome and anticoagulant and antithrombotic therapy and its application. The polypeptide involved in the present invention is derived from human fibrinogen, can bind to human platelet GPIIb-IIIa receptors, can block platelet aggregation induced by adenosine diphosphate, arachidonic acid and thrombin, and can inhibit arterial thrombosis. For acute coronary syndrome, unstable angina, acute myocardial infarction, anticoagulant and antithrombotic therapy for interventional therapy, etc. Background technique [0002] Acute coronary syndrome (ACS) refers to a group of clinical symptoms caused by acute myocardial ischemia, usually due to coronary atherosclerotic plaque rupture or surface erosion, which induces thrombosis or vasospasm, causing myocardial oxygen supply Severe myocardial ischemic events cau...

AI Technical Summary

Problems solved by technology

The commonly used clinical preparations of aspirin and clopidogrel are oral preparations. For ACS patients admitted to the emergency department, clopidogrel takes a long time to take effect when taken orall

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