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Preparation method for gallnut sustained release gel

A technology of slow-release gel and gallnut, which is applied in the field of preparation of gallnut slow-release gel, to achieve the effect of good stretchability, plump cell body and uniform texture

Inactive Publication Date: 2013-02-13
张爽
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, it has not been reported as a mature therapeutic drug in clinical practice.

Method used

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  • Preparation method for gallnut sustained release gel
  • Preparation method for gallnut sustained release gel
  • Preparation method for gallnut sustained release gel

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Embodiment Construction

[0036] The preparation method of Galla gall slow-release gel of the present invention, it comprises the steps:

[0037] The first step, the preparation of Galla gall freeze-dried powder:

[0038] Weigh 400 g of Galla gallica original drug, knock it open, wash it to remove insect scale, and dry it in a cool and ventilated place; use a low-temperature ultra-fine pulverizer (ZMD-40, Jiangsu, China) to carry out ultra-fine pulverization at 0 ° C, pass 140 Mesh sieve, add 1200ml deionized water, shake at room temperature 150rpm for 48 hours (use HYD constant temperature shaker, made by Wuhan Scientific Instrument Factory, Chinese Academy of Sciences), filter, centrifuge, take supernatant, put it in -70℃ freezer for 12 hours Take it out, use a lyophilizer (Christ Alpha1-2, Germany) to run for 288 hours under the condition of 0.6mbar, and make 150g of light yellow lyophilized powder, refrigerate at 4°C after 60Co irradiation for 30 minutes;

[0039] The second step, gel preparation...

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Abstract

The present invention discloses a preparation method for gallnut sustained release gel. The method comprises: 1, weighing a gallnut raw drug, crushing, and screening with a sieve having 140 meshes; shaking with deionized water, filtering and centrifugating; taking supernatant, placing the supernatant in a freezer to carry out freezing, and then placing the frozen material in a freeze dryer to prepare into freeze dried powder; carrying out irradiation by 60Co, and carrying out cold preservation at a temperature of 4 DEG C to provide a spare use; 2, taking dichloromethane and triacetin to prepare into a mixed solvent, then adding a poly lactic acid-glycolic acid copolymer, and adding the prepared freeze dried powder after dissolving, wherein a ratio of the mixed solvent to the poly lactic acid-glycolic acid copolymer to the prepared freeze dried powder is 61:35:4; completely and uniformly stirring, and carrying out vortex shaking to prepare light yellow gallnut gel; preserving the light yellow gallnut gel away from light for 24 hours at a temperature of 4 DEG C to obtain the finished product. The gallnut sustained release gel of the present invention has the following advantages that: the gallnut sustained release gel coagulates after contacting the water, such that periodontal membrane cells easily proliferate, and preferentially occupy the surface of the tooth root to form the new adhesion; the gallotannin provides a broad-spectrum antibacterial effect for the common putative periodontal pathogens; the gallnut sustained release gel of the present invention is adopted as the drug for prevention and treatment of periodontal diseases and has the pharmaceutical value and the economic value of in-depth research and development.

Description

technical field [0001] The invention relates to a slow-release agent for treating periodontal disease, in particular to a preparation method of Galla gall slow-release gel. Background technique [0002] Periodontal disease is a common and frequently-occurring disease in the oral cavity, and it is one of the main causes of tooth loss in adults. The treatment of periodontal disease is generally divided into surgical treatment and non-surgical treatment. Non-surgical treatment is to eliminate plaque and other local irritating factors through mechanical curettage, supplemented by drug treatment to control and improve the treatment effect, and reduce recurrence. However, these treatment methods have not yet achieved satisfactory clinical efficacy, and the difference between basic treatment and drug adjuvant treatment in reducing the depth of periodontal pockets is not large (mostly within 1mm). When periodontal disease develops to a more serious stage, surgical treatment is req...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/06A61K35/64A61K47/34A61P1/02
Inventor 张爽孙翔殷霄王翎宇王鹏飞张春喜慕秀囡唐荣银王怡心张莹程燕民王建华苏智勇随丽娜
Owner 张爽
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