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Apocynum venetum leaf valid target and application thereof

A technology of effective parts and essential hypertension, applied in the field of biomedicine, can solve problems such as applications that have not been reported, and achieve the effect of increasing anti-hypertension

Inactive Publication Date: 2013-12-25
SUZHOU FAMO BIOLOGICAL TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

This patented technology has been developed into an antihypertensive drug called APOXINVES® (APC). It can be used on both high blood pressure patients who are taking it regularly without causing side effects such as stomach pain caused by its ingestion.

Problems solved by technology

This patents describes different ways to enhance the effects of chemotherapy against cancer called oxidency action potential blockers(oximilators). These techniques include administering agents like beta adrenergnexone, alpha agonists, histamines, nitrogen monoesters, prostaglandins, angioplastomy, radiofrequency therapies, hormones, growth stimulation, platelet aggregability modifiers, iron suppression, and stem cell transplantation. However, these methods aim at addressing specific causes associated with disease states without affecting others' physiological responses.

Method used

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  • Apocynum venetum leaf valid target and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] Embodiment 1. The effect of the active parts of Apocynum leaf on the blood pressure of spontaneously hypertensive rats (SHR)

[0025] (1) Experimental animals

[0026] 12-week-old spontaneously hypertensive rats (SHR), half male and half male.

[0027] (2) Experimental grouping

[0028] (1) Model control group: they were given normal saline, orally gavaged for 14 consecutive days, with a volume of 2 ml.

[0029] (2) Low-dose group of effective parts of Apocynum leaves: 50 mg / kg of effective parts of Apocynum leaves (the total flavonoid content is 79%, the same below) was given by gavage for 14 consecutive days, and the administration volume was 2 ml.

[0030] (3) The middle dose group of the effective part of Apocynum leaf: 100 mg / kg of the effective part of Apocynum leaf was given by intragastric administration for 14 consecutive days, and the administration volume was 2 ml.

[0031] (4) High-dose group of effective part of Apocynum leaf: 200 mg / kg of effective part...

Embodiment 2

[0042] Example 2. Acute Toxicity Study on Mice of Active Parts of Apocynum Apocynum Leaf

[0043] (1) Purpose of the test

[0044] Investigate the toxic reaction and death situation produced by the test animal after one-time administration (gastric administration) of the effective part of the test substance Apocynum venetus leaf.

[0045] (2) Test materials

[0046] (1) Test substance

[0047] Effective parts of apocynum leaves (the total flavonoid content is 79%)

[0048] (2) Test animals

[0049] Name: Mouse

[0050] Strain: Kunming species

[0051] Weight: 20±2g

[0052] Gender: Both male and female

[0053] Number of animals in each group: 10 (half male and half female)

[0054] Pre-treatment of the test animals: Observe the test animals in the breeding observation room 7 days in advance (room temperature: 21-23°C; relative humidity: 30-60%, 12-hour light: 8Am-8Pm), eat machine feed, drink tap water . Fasting for 16 hours before gavage administration, water suppl...

Embodiment 3

[0059] Embodiment 3. Antihypertensive Clinical Efficacy Experiment

[0060] Shi, male, 60 years old, has essential hypertension and often suffers from dizziness and headache. After taking the capsule prepared from the effective part of Apocynum leaf for 5 days (0.3g / grain, 2 capsules / time, 3 times / day), blood pressure was significantly reduced, and the side effects of Apocynum leaf preparation did not occur (nausea, vomiting, diarrhea, epigastric discomfort).

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Abstract

The invention belongs to the technical field of medicines, and discloses an apocynum venetum leaf valid target and an application thereof. The apocynum venetum leaf valid target provided by the invention is a flavonoid substance with purity of more than 50%. The apocynum venetum leaf valid target provided by the invention is capable of substantially reducing blood pressure of SHR hypertension rats. The valid target can be prepared into any clinically or pharmaceutically acceptable dosage form, and preferably an oral preparation.

Description

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Claims

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Application Information

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Owner SUZHOU FAMO BIOLOGICAL TECH
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