Compound seabuckthorn seed oil vaginal expansion suppository and its preparation method and detection method

Abstract

The invention relates to a compound seabuckthorm seed oil expandable vaginal suppository, and a preparation method and a detection method thereof. The expandable vaginal suppository comprises seabuckthorn seed oil, a traditional Chinese medicine composition, a matrix and an expansion carrier. The traditional Chinese medicine composition is prepared from raw materials of Sophora flavescens and Cnidium monnieri; and the drug-containing matrix of the expandable vaginal suppository comprises an emulsifier, a slow-release agent and carnauba wax. The emulsifier can stabilize the seabuckthorn seed oil and inhibit the volatilization effect; the carnauba wax can promote absorption of active ingredients by the vagina, and cooperate with the slow-release agent to of prolong effect of the active components on the vagina and prolong the curative effect of the suppository. The compound seabuckthorm seed oil expandable vaginal suppository employs seven originally-created leading technologies and has the beneficial effects of prevention of outflow liquid, high stability and lasting effect.

Description

[0001] Technology collar bath [0002] The invention belongs to the field of vaginal suppositories, in particular to a compound seabuckthorn seed oil vaginal expansive suppository, a preparation method and a detection method thereof. Background technique [0003] The compound seabuckthorn seed oil suppository is recorded in the 40th volume of "New Drug Standardization", which is mainly made of seabuckthorn seed oil, Cnidium monnieri, Sophora flavescens, calamine, frankincense, myrrh, borneol and matrix, and has the functions of clearing away heat and dampness , reduce swelling and relieve pain, kill insects and relieve itching, promote blood circulation and promote muscle growth, and is used for cervical erosion caused by damp-heat betting; Symptoms: excessive leucorrhea, yellow or white color, bloody leucorrhea or bleeding after sexual intercourse, genital itching, swelling and pain, symptoms such as waist and abdomen swelling; some documents in the prior art disclose the sup...

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Problems solved by technology

[0003] The compound seabuckthorn seed oil suppository is recorded in the 40th volume of "New Drug Standardization", which is mainly made of seabuckthorn seed oil, Cnidium monnieri, Sophora flavescens, calamine, frankincense, myrrh, borneol and matrix, and has the functions of clearing away heat and dampness , reduce swelling and relieve pain, kill insects and relieve itching, promote blood circulation and promote muscle growth, and is used for cervical erosion caused by damp-heat betting; Symptoms: excessive leucorrhea, yellow or white color, bloody leucorrhea or bleeding after sexual intercourse, genital itching, swelling and pain, symptoms such as waist and abdomen swelling; some documents in the prior art disclose the suppository of compound seabuckthorn seed oil, such as, CN1387896 discloses a combination of seabuckthorn seed oil, cnidium, flavescens, calamine, frankincense, myrrh 1. Active ingredients made from borneol and suppositories made from glycerin gelatin. The suppository has the problem of poor stability, and because seabuckthorn seed oil is volatile, it affects the content of active ingredients in the suppository and affects the curative effect of the suppository; and because the oil itself Unstable in nature, after it is mixed with the base, it will accelerate the denaturation of seabuckthorn seed oil and affect the stability of suppositories

[0004] There are not many studies on the compound seabuckthorn seed oil suppository in the prior art, and the following problems still need to be solved: 1. The tampon in the traditional compound seabuckthorn seed oil suppository has no swelling effect, or the expansion is disordered, which greatly reduces the clinical 2. The drug release is fast, and there is a "peak and valley" phenomenon; 3. The quality control method is unreliable, which leads to great changes in the content, stability, and melting time limit between batches in the actual production process, etc.

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