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Biomarker panels, diagnostic methods and test kits for ovarian cancer

A biomarker, ovarian cancer technology, applied in biological testing, methods using particle spectrometers, biomaterial analysis, etc., can solve problems such as no effective testing for early detection

Inactive Publication Date: 2014-02-12
VERMILLION INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Most importantly, there are no effective tests for early detection

Method used

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  • Biomarker panels, diagnostic methods and test kits for ovarian cancer
  • Biomarker panels, diagnostic methods and test kits for ovarian cancer
  • Biomarker panels, diagnostic methods and test kits for ovarian cancer

Examples

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Embodiment 1

[0540] The following discussion and examples are provided to describe and illustrate the invention. As such, they should not be construed as limiting the scope of the invention. Those skilled in the art will appreciate that many other embodiments are within the scope of the invention, as described in the specification and claims.

[0541] Analyze data using a knowledge discovery engine

[0542] Correlogic describes the use of evolutionary and pattern recognition algorithms to evaluate complex datasets, including the Knowledge Discovery Engine (KDE TM )and See, eg, Hitt et al., U.S. Patent No. 6,925,389, "Process for Discriminating Between Biological States Based on Hidden Patterns From Biological Data" (issued August 2, 2005); Hitt, U.S. Patent No. 7,096,206, "Heuristic Method of Classification ,” (issued August 22, 2006) and Hitt, US Patent No. 7,240,038, “Heuristic Method of Classification,” (issued July 3, 2007). US Published Patent Application 2006 / 0064253, Hitt et ...

Embodiment 2

[0575] Sera were obtained from a prospective collection dedicated to the development and validation of ovarian cancer test performance. All samples were collected in a uniform protocol from 11 different sites and compliance was monitored. The Western Academic Review Board (Olympia, WA) and the IRBs at each site approved the study under FDA Investigational Device Exemption (IDE) number G050132. Collection sites (and IRBs) were: Cedars-Sinai Medical Center, Los Angeles, CA (Cedars-Sinai Institutional Review Board); Florida Gynecologic Oncology, Fort Meyers, FL (Lee Memorial Health System Institutional Review Committee); Florida Hospital Cancer Institute, Orlando, FL (Florida Hospital Institutional Review Board); The Harry and Jeanette Weinberg Cancer Institute at Franklin Square Hospital, Baltimore, MD (MedStar Research Institute Georgetown Oncology Institutional Review Board); Holy Cross Hospital, Silver Spring, MD (Holy Cross Institution Board); North Shore-Long Island Jewish...

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Abstract

Methods are provided for predicting the presence, subtype and stage of ovarian cancer, as well as for assessing the therapeutic efficacy of a cancer treatment and determining whether a subject potentially is developing cancer. Associated test kits, computer and analytical systems as well as software and diagnostic models are also provided.

Description

[0001] related application [0002] This application claims the benefit of US Provisional Application Serial No. 61 / 463,870, filed February 24, 2011, the entire contents of which are incorporated herein by reference. [0003] statement of government support [0004] The subject of this application includes work supported by SBIR Award No. HHSN261200800045C entitled "Improvement of a Promising MAP for Ovarian Cancer" from the National Cancer Institute. technical field [0005] The present invention provides methods for predicting and diagnosing ovarian cancer, especially epithelial ovarian cancer, and also provides related analysis reagents, diagnostic models, test kits and clinical reports. Background technique [0006] The American Cancer Society estimates that ovarian cancer affected 22,430 women and killed 15,280 in the United States in 2007. However, ovarian cancer is not a single disease, and there are actually more than 30 types and subtypes of ovarian malignancies, ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N33/53G01N33/68G01N33/574G01N33/532
CPCG01N33/57449G16H50/30G01N33/68G01N33/532G01N33/53G01N33/574G01N33/57488G01N2333/705G01N2333/8107H01J49/0027
Inventor 格雷格·P·贝尔滕肖平·F·叶帕塔·塞莎亚
Owner VERMILLION INC
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