Serum specificity metabolite spectrum for patient with lung cancer, and building method thereof

Abstract

The invention discloses a serum specificity metabolite spectrum for a patient with a lung cancer and a building method thereof, and particularly discloses a method for carrying out liquid-phase/gas-phase chromatography mass spectrometry metabonomics analysis based on the patient suffering from the lung cancer. The method comprises the following steps: collecting fasting blood samples of a healthy and normal detected person and the patient suffering from the lung cancer 7 days before and after an operation, separating by a chromatogram column after processing; extracting and aligning original data of an instrument after adopting mass spectrometry analysis; building a mathematical model to analyze the metabolites spectrum by adopting multivariable data statistical software; comparing with the difference between an average person with the metabolites spectrum of the patient with the lung cancer, so as to determine the specificity metabolite spectrum. By adopting the method disclosed by the invention, the mutation status of the metabolite of the patient with the lung cancer can be generally and comprehensively reflected, and the serum specificity metabolite spectrum can be applied to early diagnosis of the lung cancer or a beneficial technical support is supplied for prognosis.

Description

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AI Technical Summary

Benefits of technology

This patented technology allows researches into identifying small molecules that may be associated with certain diseases or conditions like lung disease. These compounds have been identified through various techniques such as liquidchromatography (LC), quadrupolar ion exchange resins, Gas Chromatoxygraphics(GC) scan, and gas microelectrospray spectroscopy (GMS). They also found that these compound patterns were significantly different when comparing them to those seen during routine medical procedures. Overall, this technique offers an efficient way to diagnose pulmonary tuberculosis without causing any harmful side effect.

Problems solved by technology

This patented describes how metabolism plays a crucial role in determining whether pneumoniae colonies develop within 2-5 months postoperational stages due to their rapid growth rates at this point. However, traditional methodologies like histochemistry cannot provide accurate results because these tests require expensive equipment and trained staff. Liquidchromatomy-quantifying metabolite levels provides new opportunities for developing better ways to identify disease earlier than existing methods while reducing invasiveness and cost associated with them.

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