Application of Sanguinarine and Its Salts as Spermicides

A technology of sanguinarine and sperm, which is applied in the field of biomedicine, can solve the problems that the spermicidal effect of sanguinarine and its salt has not been reported, and achieve good spermicidal and contraceptive effects, expand medicinal value, and prevent sexually transmitted diseases.

Inactive Publication Date: 2017-09-15
HUNAN INSTITUTE OF SCIENCE AND TECHNOLOGY +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

According to literature reports, sanguinarine and its salts have rich pharmacological activities, such as bactericidal, antiviral, insecticidal, snail killing, cercaricidal and antitumor effects, but the spermicidal effect of sanguinarine and its salts has not been seen so far. to report

Method used

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  • Application of Sanguinarine and Its Salts as Spermicides
  • Application of Sanguinarine and Its Salts as Spermicides
  • Application of Sanguinarine and Its Salts as Spermicides

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Embodiment 3

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Abstract

The invention discloses the application of sanguinarine and its salt as external spermicide for women. Its notable feature is that it can kill sperm quickly with low concentration, and it is cheap, safe and reliable. The minimum spermicidal concentration of sanguinarine aqueous solution (pH=4.5) was 0.25 mg / L for 20 seconds, and 0.15 mg / L for 3 minutes. The low spermicidal concentration in the anti-fertility test was 0.5 mg / kg with an ED50 value of 0.129 mg / kg. Compared with the commonly used nonoxynol, sanguinarine has better spermicidal indicators than nonoxynol, and it is expected to become a new type of high-efficiency external contraceptive for women.

Description

Application of Sanguinarine and Its Salts as Spermicides technical field The invention relates to the discovery of a new application of sanguinarine and its salts, specifically the preparation of female external (vaginal) spermicidal and contraceptive drugs with sanguinarine and its soluble salts as main components, which belongs to the field of biomedicine. Background technique Contraception is a widely studied content in the field of reproduction and family planning. There are many methods of contraception, such as contraceptive pills, condoms, diaphragms, rhythm contraceptive methods, extracorporeal ejaculation contraceptive methods, surgical contraceptive methods, etc., among which The use of birth control pills (for women) is most common. There are also many types of contraceptives, such as external spermicides and oral contraceptives. Because external spermicides generally do not interfere with women's endocrine functions, are cheap, easy to use, and have the effect ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/4741A61P15/18
Inventor 钟明冯务群阎建辉易健民唐课文向阳
Owner HUNAN INSTITUTE OF SCIENCE AND TECHNOLOGY
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