45 results about "Anti fertility" patented technology

Methods and compositions for inhibiting or preventing spermatogenesis in a male mammal. Also disclosed are compounds and formulations for use in such methods.

The invention discloses an epididymal protease inhibitor protein monoclonal antibody and application thereof, which belong to the field of biological engineering. The monoclonal antibody is secreted by hybridoma preserved in China Center for Type Culture Collection (CCTCC) with the preservation number of C200849. The monoclonal antibody can be combined to the epididymal protease inhibitor protein Eppin protein of specific expression in a testis and epididymis tissue by specificity. The monoclonal antibody can be used for preparing male infertility diagnostic reagents, male contraceptives and anti-fertility study biological products.

The invention discloses two optimization methods for attenuated processing of tripterygium wilfordii and the relevant preparations thereof. The optimization method (1) is that under the optimized condition, the traditional Chinese medicine tripterygium wilfordii is processed with salt water (or processed with acid) and processed with the acid (or processed with the salt water), or acid solution containing chloride ion is used for attenuation; the optimization method (2) comprises the following steps: under the optimized condition, tripterygium wilfordii extract, or the further purified product of the tripterygium wilfordii extract, or tripterygium wilfordii preparation is processed with the salt water (or processed with the acid) and processed with the acid (or processed with the salt water), the detailed method is described in the specifications. The methods have the advantages that the relevant preparations of the tripterygium wilfordii with the relatively low toxicity are obtained by the optimization of processing method, the medicinal resources of herb, root and bark, stem leaf parts of the tripterygium wilfordii with strong toxicity are utilized better, and the curative effect of tripterygium wilfordii preparations is strengthened. The methods of the invention simultaneously have the advantages of simple operation, low cost and being easy for popularization. The relevant preparations of the invention are used for treating rheumatoid arthritis, chronic nephritis, hepatitis, thrombopenic purpura and various dermatoarthritis, and can be used for resisting generation, anti-tumor, resisting rejection in the body after organ transplantation, etc.

The invention discloses a kind of ant bearing mouse trap agent, its use and its formula to kill and control the mouse breed. It contains the phosphine oxide aziridine barren medicament, the dait agent and rop findings, the main element, phosphine oxide aziridine can cause gland hurt for female mouse, the sperm occur barrier, at the same time, hae outstanding breed toxicity for female mouse, and can pass through the embryo and latex to transmit to descendant, seriously affect the bearing ability of descendant mouse. The mouse trap can escape the secondary hazarded phenomenon that bring by the traditional mouse trap, at the same time, the mouse cannot appearance the drastic reaction, such as bleed and convulsion after take in the mouse trap solvent, cannot cause awake of mouse, even more appearance the quickly rebound phenomenon of mouse group number after population vacuum, thus, it is a kind of biology ant bearing mouse trap agent that is safe and efficient, can use long period.

The present invention discloses a quinazol derivative of a structural formula I, comprising the 3-substituted-4(3H)-quinazol derivative (compound 1-8) and the 6- substituted-4(3H)-quinazol derivative (compound 9-27). By testing each of the target compounds of the present invention in vitro inhibition of human sperm acrosin activity, the result shows that, compared with the publically reported acrosin inhibitor TLCK (N-toluene sulfonyl-L-lysyl-chloromethyl ketone), all target compounds have inhibit activity to human sperm acrosin. The quinazol derivative can be applied for preparing anti-fertility drugs and providing a new male contraceptive medicine in clinical field, and has a great application value. The present invention further provides a preparation method of the derivative I.

The invention discloses steroidal saponin derivatives, and a preparation method and application thereof. According to the invention, pseudoprodioscin is used as a substrate; a Chaetomium olivaceum strain is used as a biotransformation bacterium for biotransformation; and separation is finally carried out so as to obtain the steroidal saponin derivatives as shown in formula I to formula V in the specification. Pharmacological experiments prove that the steroidal saponin derivatives as shown in formula I to formula V have excellent antineoplastic activity and thrombolytic activity, substantial protection activity to myocardial cells and low toxicity to normal cells; so the steroidal saponin derivatives have important application prospects in cancer prevention, treatment of the diseases of cardiovascular systems, improvement of immunity, reduction in blood sugar, anti-fertility action, bacterium resistance, etc.

The utility model relates to a whole human anti follicule-stimulating hormone (FSH) Beta single chain antibody. Phage antibody that contains anti-A epitope antibody genes is screened out from the whole human single chain phage antibody library and conducted soluble expression to get the whole human single chain antibody of anti FSH-Beta A epitope; the A epitope is the 33-53 amino acid residue on FSH-Beta subunit and comprises the amino acid sequence of Glu-Glu-Cys-Arg-Phe-Cys-Ile-Ser-Ile-Asn-Thr-Thr-Trp-Cys-Ala-Gly-Tyr-Cys-Try-Thr-Arg. The utility model also relates to a method that utilizes phage display technology to screen the whole human anti FSH-Beta single chain antibody. The whole human anti FSH-Beta single chain antibody of the utility model can be applied to the purposes of anti-fertility, detection kit preparation and relevant diseases treatment.

The invention discloses an epididymis protease inhibition protein B-cell epitope and a multiple antigenic peptide containing the epitope; the epididymis protease inhibition protein B-cell epitope of the invention has amino acid sequences shown in SEQ ID No.1 and has single component and simple structure, and is free of the impact of bad epitopes in natural proteantigens, and immunoreactions initiated by the epitope of the invention has strong pertinence; the multiple antigenic peptide containing the epididymis protease inhibition protein B-cell epitope, is obtained by connecting a T accessory cell epitope with the epididymis protease inhibition protein B-cell epitope on a branch of a tree-based core formed by a bifunctional unit or a plurality of bifunctional units; the multiple antigenic peptide can induce that an antibody of the epididymis protease inhibition protein B-cell epitope is targeted with high titer in a specific manner and a reversible anti-fertility function with high efficiency and safety is produced, thereby being capable of preparing a male pregnancy vaccine, having significant social and economic benefits and having important value in theory and wide application prospect.

The invention relates to the field of medicines, and discloses an anti-fertility medicine, wherein the anti-fertility medicine contains a podophyllotoxin compound and is applied to spermicidal contraception for mammals. Also disclosed is a pharmaceutical preparation; the pharmaceutical preparation contains an active ingredient, wherein the active ingredient is the anti-fertility medicine provided by the invention. The invention also provides an application of the podophyllotoxin compound in preparation of the anti-fertility medicine, wherein the anti-fertility medicine is applied for spermicidal contraception in genital tracts of the mammals. The podophyllotoxin compound provided by the invention can be directly used as a drug for spermicidal contraception in genital tracts of female mammals, especially as a drug for spermicidal contraception in genital tracts of human female, and has high safety and low toxicity to human body organs. Therefore, the anti-fertility medicine provided by the invention has quite important practical significance and application promotion value for improving the level of reproductive health.

The invention discloses a follicle-stimulating hormone recipient B cell epitope and an antigenic peptide containing the epitope; the follicle-stimulating hormone recipient B cell epitope of the invention has amino acid sequences shown in SEQ ID No.1 and has single component and simple structure, and are free of the impact of bad epitopes in natural proteantigens, and immunoreactions initiated by the epitope of the invention has strong pertinence; the antigenic peptide containing the follicle-stimulating hormone recipient B cell epitope, is obtained by connecting a T accessory cell epitope with the follicle-stimulating hormone recipient B cell epitope in series while the T cell epitope has the amino acid sequences shown in SEQ I D No.2; the antigenic peptide can induce that an antibody of the follicle-stimulating hormone recipient B cell epitope is targeted with high titer in a specific manner and a reversible anti-fertility function with high efficiency and safety is produced, thereby being capable of preparing a male pregnancy vaccine, having significant social and economic benefits and having important value in theory and wide application prospect.

The invention mainly relates to a control method of grassland rodents. Brandt's vole is one of main rodents in Inner Mongolia Grassland. The invention provides a novel method for controlling the number of the Brandt's vole population by using the mint oil. According to the novel method, a mature non-overwintering Brandt's vole is used as an experimental subject, mint oil with different concentrations is used for performing intragastric administration on the Brandt's vole, autopsy is performed, the embryo implantation situation in the uteruse of the Brandt's vole is statistically recorded, and the uterus is collected for performing histopathological research and analysis. Experiments show that the mint oil has a significant anti-fertility effect on the Brandt's vole, and can effectively reduce the embryo implantation number of the Brandt's vole and reduce the reproduction rate of the Brandt's vole. Researches shown that the mint oil can effectively control the reproduction rate of the Brandt's vole, and thus control the number of the Brandt's vole population, so that sufficient evidence is provided for application of the mint oil as a potential botanical sterilant to rodent sterility control.