35 results about "Follicle-stimulating hormone receptor" patented technology

This invention provides pyrrolobenzodiazepine pyridine carboxamides selected from those of Formula (1), which act as follicle stimulating hormone receptor antagonists. The invention also provides pharmaceutical compositions and methods of treatment utilizing the compounds of Formulae (1) and (2).

The invention provides compounds of formula or a pharmaceutically acceptable salt thereof, wherein R, R1, R2, R3, and B are as defined in the accompanying specification. Methods of making such compounds are also provided.

The invention provides compounds of formula or a pharmaceutically acceptable salt thereof, wherein R, R1, R2, R3, A, and B are as defined in the accompanying specification. Methods of making such compounds are also provided.

This invention provides pyrrolobenzodiazepine arylcarboxamides selected from those of Formula (1), which act as follicle stimulating hormone receptor antagonists, as well as pharmaceutical compositions and methods of treatment utilizing these compounds.

The present invention relates to pyrazole compounds, and pharmaceutically acceptable compositions thereof, useful as positive allosteric modulators of follicle stimulating hormone receptor (FSHR).

The invention discloses a follicle-stimulating hormone recipient B cell epitope and an antigenic peptide containing the epitope; the follicle-stimulating hormone recipient B cell epitope of the invention has amino acid sequences shown in SEQ ID No.1 and has single component and simple structure, and are free of the impact of bad epitopes in natural proteantigens, and immunoreactions initiated by the epitope of the invention has strong pertinence; the antigenic peptide containing the follicle-stimulating hormone recipient B cell epitope, is obtained by connecting a T accessory cell epitope with the follicle-stimulating hormone recipient B cell epitope in series while the T cell epitope has the amino acid sequences shown in SEQ I D No.2; the antigenic peptide can induce that an antibody of the follicle-stimulating hormone recipient B cell epitope is targeted with high titer in a specific manner and a reversible anti-fertility function with high efficiency and safety is produced, therebybeing capable of preparing a male pregnancy vaccine, having significant social and economic benefits and having important value in theory and wide application prospect.

In order to solve the problem of accurate identification of lesions during surgery, on the basis of the advantages of near-infrared fluorescent dyes for imaging, its specific imaging is increased. The invention provides a tumor imaging and treatment probe targeting follicle stimulating hormone receptor and a preparation method thereof. In the present invention, the follicle stimulating hormone polypeptide (LYTRDLVYKDPARPKIQKTCTF) is coupled with the near-infrared fluorescent dye Rh760 to form the follicle stimulating hormone receptor-targeted tumor imaging and therapy probe FSH-Rh760. The advantage is that the present invention utilizes FSHR to be highly expressed in ovarian cancer , based on the principle of specific binding of FSH polypeptides to FSHR, targeting ovarian cancer cells. Utilizing the advantages of deeper penetration depth and lower background signal of the near-infrared fluorescent dye Rh760, it has a good application prospect in fluorescence imaging and fluorescence-guided surgery. The targeting probe FSH-Rh760 of the present invention can be used for photothermal therapy of ovarian cancer, as a supplement to surgical treatment, to improve the prognosis of ovarian cancer.

The invention provides compounds of formulaor a pharmaceutically acceptable salt thereof, wherein R, R1, R2, R3, and B are as defined in the accompanying specification. Methods of making such compounds are also provided.

The present invention relates to compositions and methods for diagnosing and treating diseases, disorders or conditions associated with dysregulated expression of FSHR. The invention provides novel peptides that specifically bind to Follicle-stimulation hormone receptor (FSHR).

The invention discloses preparation and application of an anti-FSHR (follicle stimulating hormone receptor) antibody and an antibody-drug conjugate thereof. The invention discloses an antibody or an antigen-binding fragment thereof, the antibody or the antigen-binding fragment thereof comprises a variable region which specifically binds to a human follicle stimulating hormone receptor (FSHR) and comprises one, two, three, four, five or six CDRs selected from amino acid sequences shown as SEQ ID NO: 6, 7, 8, 10, 11 and 12, and the antibody or the antigen-binding fragment thereof comprises one, two, three, four, five or six CDRs selected from amino acid sequences shown as SEQ ID NO: 6, SEQ ID NO: 7, SEQ ID NO: 8, SEQ ID NO: 10, SEQ ID NO: 11 and SEQ ID NO: 12. The anti-FSHR antibody and the antibody-drug conjugate thereof provided by the invention have wide application prospects in detection, screening, prevention and treatment of cancers.

Disclosed are pyrazole compounds, and pharmaceutically acceptable compositions thereof. The compounds and the compositions can be used for positive allosteric modulators of follicle stimulating hormone receptor (FSHR).