5 results about "Fertility Disorders" patented technology

The invention relates to the technical field of monoclonal antibody preparation and immunological detection, in particular to a reagent or a kit for detecting E2 through an antibody sandwich method and application of the reagent or the kit. The paired monoclonal antibody has strong specificity and high detection sensitivity, and solves the problems of low content of E2 in human serum and high detection difficulty. The monoclonal antibody is applied to a magnetic particle estradiol content detection kit. The kit is used for detecting the E2 content in serum, is combined with other sex hormone index detection and clinical manifestation, is beneficial to diagnosis of sex hormone disorder diseases, and has clinical significance in detection of diseases such as fertility disorders in thalamus-pituitary-gonad axis, male mammary gland development, estrogenic ovarian and testicular tumors, adrenal cortex hyperplasia and the like.

Substituted furopyrimidine chemical entities of general formula (I): wherein R a has any of the values described herein, and compositions comprising such chemical entities; methods for preparing them; and their use in various methods, including metabolic and reaction kinetics studies; detection and imaging techniques; radiotherapy; modulating and treating disorders mediated by PDE1 activity or dopaminergic signaling; treating neurological disorders, CNS disorders, dementia, neurodegenerative diseases, and trauma-dependent loss of function; treating stroke, including cognitive and motor function deficits during stroke rehabilitation; promoting neuroprotection and neurorestoration; enhancing the efficiency of cognitive and motor training, including animal skill training protocols; and treating peripheral disorders, including cardiovascular disorders, renal disorders, hematological disorders, gastrointestinal disorders, liver disorders, cancer, fertility disorders, and metabolic disorders.

The present invention relates to a method for isolating stem cells comprising preparing a cell suspension from uterine cervix tissue, to the stem cells isolated by said method, and to the conditioned medium obtained from the culture of said stem cells. The invention also encompasses the use of said stem cells or conditioned medium for treating or preventing cancer, precancerous lesions, inflammatory diseases, autoimmune diseases, chronic pathologies or infectious diseases, diseases associated to tissue loss, or for use in diagnostic, prognostic or treatment of fertility disorders, as well as for cosmetic treatment.

The invention discloses a method for relieving tomato pollen high-temperature fertility disorder, and relates to the technical field of biology, and the method specifically comprises the step of overexpressing carbonic anhydrase gene betaCA2.2 in tomatoes or increasing the activity of protein coded by the carbonic anhydrase gene betaCA2.2. Furthermore, carbonic anhydrase gene betaCA2.2 overexpression strains OE: betaCA2.2-1 and OE: betaCA2.2-2 are obtained through screening by using a transgenic technology and a tissue culture technology, compared with wild WT, the overexpression strains have the advantages that the pollen activity at high temperature is remarkably improved, the intracellular pH change is remarkably stable, the tomato pollen fertility disorder caused by high-temperature stress is relieved, and the tomato pollen fertility disorder caused by high-temperature stress is relieved. The tomato fruit setting rate under high-temperature stress is obviously improved, and an important gene resource is provided for cultivating high-temperature-resistant tomato varieties.

This invention discloses the application of the compound pimozide in combination with metronidazole in the preparation of a drug for improving oocyte quality and treating endometriosis-related fertility disorders, belonging to the field of biomedical technology. The efficacy of this invention was verified by constructing mouse models of endometriosis driven by pathogenic *Prevotella bisporus* and mouse models of ovarian endometriosis. Experimental results showed that the combined administration significantly eliminated *Prevotella bisporus* colonizing ectopic lesions, reduced succinic acid content in both eutopic and ectopic lesions, decreased the succinylation level of lysine residue 195 of the ACADVL protein, reduced the fluidity of primary endometrial epithelial cell membranes, reduced the volume and weight of endometriotic lesions, and improved oocyte spermatogenesis, ovulation rate, and litter size. This invention solves the problem that existing therapies cannot simultaneously control endometriosis lesions and protect reproductive function, providing a new, safe, and effective combined treatment option for patients with endometriosis and infertility.