Ligands of the fsh hormone receptor in the diagnosis and treatment of tumors

A technology of receptors and ligands, applied in the medical field, can solve problems such as neuroblastoma not displayed

Pending Publication Date: 2019-07-30
恩科格林医疗股份公司
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  • Ligands of the fsh hormone receptor in the diagnosis and treatment of tumors
  • Ligands of the fsh hormone receptor in the diagnosis and treatment of tumors
  • Ligands of the fsh hormone receptor in the diagnosis and treatment of tumors

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[0072] definition

[0073] In the description of the present invention, the terms shall be understood to have the following meanings unless otherwise specified.

[0074] "FSHR" refers to the human follicle-stimulating hormone (FSH) receptor; this hormone includes two subunits, alpha and beta.

[0075] "FSH beta" refers to the single beta subunit of human follicle stimulating hormone (FSH); this subunit is characterized by a sequence corresponding to SEQ.ID.no.1.

[0076] "ABRβ" refers to the β subunit of human follicle stimulating hormone (FSH) obtained using a biotechnology platform according to the present invention.

[0077] "ABRβ1" refers to the specific β subunit of human follicle-stimulating hormone (FSH) obtained according to the present invention using a biotechnology platform produced in Nicotiana benthamiana plant cells; this subunit is characterized by Sequence corresponding to SEQ.ID.no.2.

[0078] In general, the FSHβ, ABRβ, and ABRβ1 subunits can be referred t...

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Abstract

The present invention relates to ligands of the follicle stimulating hormone (FSH) receptor for use in the diagnosis and treatment of tumors.

Description

technical field [0001] The invention is applied in the field of medicine, especially in the diagnosis and treatment of tumors. Background technique [0002] Follicle-stimulating hormone (FSH) is a glycoprotein belonging to the class of glycoprotein hormones (GPH), which includes proteins characterized by a high degree of structural similarity, such as thyroid-stimulating hormone (TSH), luteinizing hormone (LH), and chorion-stimulating hormone Gonadal hormones (CG). [0003] FSH is synthesized in the anterior pituitary and released into the bloodstream as a result of gonadotropin releasing hormone (GnRH) stimulation. [0004] FSH plays a key role in reproductive physiology, including the induction of follicle maturation in females and the stimulation of Sertoli cells to promote spermatogenesis in males (Simoni et al. 1997). [0005] Recombinant FSH preparations, such as and or preparations extracted from urine, such as It is routinely used in clinical practice to trea...

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Application Information

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IPC IPC(8): A61K38/24A61P35/00C07K14/59
CPCA61K38/24C07K14/59A61P35/00A61P43/00A61K47/64A01H4/001C12N5/0025C12N15/8257G01N33/6893G01N33/74A61K2800/00
Inventor 安德里亚·卡尔皮法比奥·马塞特伦佐·达尔·蒙特
Owner 恩科格林医疗股份公司
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