59 results about "Pyrrolobenzodiazepine" patented technology

A compound which is either A:

or B:

and salts and solvates thereof, as well as their conjugates with a cell-binding agent.

A conjugate of formula (A):

where Y is selected from a single bond, and a group of formulae A1 or A2:

where N shows where the group binds to the N10 of the PBD moiety;

• • R^L1 and R^L2 are independently selected from H and methyl, or together with the carbon atom to which they are bound form a cyclopropylene group;
  • CBA represents a cell binding agent;
  • Q is independently selected from O, S and NH;
  • R¹¹ is either H, or R or, where Q is O, SO₃M, where M is a metal cation.

A compound which is selected from A:

B:

and C:

and salts and solvates thereof, as well as conjugates thereof with cell binding agent.

Conjugates of an antibody that binds to CD19 with PBD dimers.

Conjugates of an antibody that binds to PSMA with PBD dimers.

Conjugates of an antibody that binds to CD25 with PBD dimers.

Conjugates of an isolated humanized, anti-CD22 antibody with PBD dimers.

Conjugates of an antibody that binds to CD25 with PBD dimers.

The present inventors have developed a key intermediate for the production of C2 substituted PBDs, which has a leaving group at the C2 position, a carbamate protecting group at the N10 position and a protected hydroxy group at the C11 position. In a first aspect, the present invention comprises a compound with a the formula (I), wherein: R¹⁰ is a carbamate-based nitrogen protecting group; R¹¹ is an oxygen protecting group; and R² is a labile leaving group. In a further aspect, the present invention comprises a method of synthesising a compound of formula (III), or a solvate thereof, from a compound of formula (I) as defined in the first aspect, R¹⁶ is either O-R11, wherein R¹¹ is as defined in the first aspect, or OH, or R¹⁰ and R¹⁶ together form a double bond between N10 and C11; and R¹⁵ is R. The other substituents are defined in the claims. Further aspects of the present invention relate to compounds of formula (III) (including solvates thereof when R¹⁰ and R¹⁶ form a double bond between N10 and C11, and pharmaceutical salts thereof), pharmaceutical compositions comprising these, and their use in the manufacture of a medicament for the treatment of a proliferative disease.

Conjugates of specific PBD dimers with an antibody that binds to CD22, the antibody comprising a VH domain having the sequence according to SEQ ID NO. 1.

A conjugate comprising a PBD dimer linked from the tether joining the two PBD units, wherein the linker is of formula (A1): (Formula (A1)) wherein R^N1 is selected from H and C_1-4 alkyl; L is a linker connected to a cell binding agent; CBA is the cell binding agent; n is an integer selected in the range of 0 to 48; Q is: (Formula (Q)), where Q^x is such that Q is an amino-acid residue, a dipeptide residue or a tripeptide residue.

This invention provides pyrrolobenzodiazepine pyridine carboxamides selected from those of Formula (1), which act as follicle stimulating hormone receptor antagonists. The invention also provides pharmaceutical compositions and methods of treatment utilizing the compounds of Formulae (1) and (2).