Triple reuptake inhibitors and methods of use thereof

A use and compound technology, applied in the compound field of triple reuptake inhibitors, can solve problems such as lagging therapeutic effects

Active Publication Date: 2019-05-07
SUNOVION PHARMA INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The main disadvantage of all these agents is that the therapeutic effect lags behind their administration - the patient must take the drug for more than 3 weeks to achieve a clinically meaningful reduction in symptoms
Moreover, a very large number of patients do not respond at all to existing treatments

Method used

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  • Triple reuptake inhibitors and methods of use thereof
  • Triple reuptake inhibitors and methods of use thereof
  • Triple reuptake inhibitors and methods of use thereof

Examples

Experimental program
Comparison scheme
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Embodiment Construction

[0019] 5.1 definition

[0020] Unless otherwise specified, the term "alkyl" used in the present invention refers to a linear or branched saturated monovalent hydrocarbon group, wherein the alkyl group may be optionally substituted by one or more substituents. The term "alkyl" also includes straight and branched chain alkyl groups unless otherwise specified. In certain embodiments, the alkyl group has 1 to 20(C 1-20 ), 1 to 15 (C 1-15 ), 1 to 12 (C 1-12 ), 1 to 10 (C 1-10 ), or 1 to 6 (C 1-6 ) straight-chain saturated monovalent hydrocarbon group of carbon atoms, or with 3 to 20 (C 3-20 ), 3 to 15 (C 3-15 ), 3 to 12 (C 3-12 ), 3 to 10 (C 3-10 ), or 3 to 6 (C 3-6 ) branched saturated monovalent hydrocarbon group of carbon atoms. The linear C used in the present invention 1-6 and branched C 3-6 Alkyl is also referred to as "lower alkyl". Embodiments of alkyl include, but are not limited to, methyl, ethyl, propyl (including all isomeric forms), n-propyl, isopropyl, ...

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PUM

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Abstract

The invention relates to a triple reuptake inhibitor and its application method, and provides a bicyclic compound and its synthesis method. The compounds provided by the present invention are useful in the treatment, prevention and / or management of various nervous system disorders. Compounds provided herein inhibit the reuptake of endogenous monoamines, such as dopamine, serotonin, and norepinephrine (eg, from the synaptic cleft), and modulate one or more monoamine transporters. The present invention also provides pharmaceutical preparations comprising the compound.

Description

[0001] This application is a divisional application of the application dated December 15, 2009, the application number is 200980156733.1, and the invention name is "triple reuptake inhibitor and its application method". [0002] This application claims priority to US Provisional Application No. 61 / 138,062, filed December 16, 2008, the entire contents of which are incorporated herein by reference. 1. Technical field [0003] The present invention provides compounds useful as triple reuptake inhibitors, compositions comprising the compounds, and methods of using them. 2. Background technology [0004] Monoamine neurotransmitters have been found to be involved in the body's response to neurological disorders such as pain and depression. Norepinephrine (NE) and serotonin (5-HT) are monoamine neurotransmitters produced in the brain and diffuse throughout the central nervous system. 5-HT and NE have been reported to be involved in regulating the transmission of pain from the spin...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07D209/10C07D209/52A61K31/403A61P25/24A61P25/28A61P25/04A61P25/20A61P25/14A61P25/22A61P25/00A61P25/16
CPCC07D209/10C07D209/52A61K31/4035A61P21/00A61P25/00A61P25/04A61P25/08A61P25/14A61P25/16A61P25/18A61P25/20A61P25/22A61P25/24A61P25/28A61P43/00C07D209/08C07D209/44
Inventor 邵黎明王凤江S·C·玛尔科姆M·C·赫维特
Owner SUNOVION PHARMA INC
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