Triple reuptake inhibitors and methods of use thereof

A use and compound technology, applied in the compound field of triple reuptake inhibitors, can solve problems such as lagging therapeutic effects
CN105384676BActive Publication Date: 2019-05-07SUNOVION PHARMA INC
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Patent Information

Authority / Receiving Office
CN Ā· China
Patent Type
Patents(China)
Current Assignee / Owner
SUNOVION PHARMA INC
Publication Date
2019-05-07

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Abstract

The invention relates to a triple reuptake inhibitor and its application method, and provides a bicyclic compound and its synthesis method. The compounds provided by the present invention are useful in the treatment, prevention and / or management of various nervous system disorders. Compounds provided herein inhibit the reuptake of endogenous monoamines, such as dopamine, serotonin, and norepinephrine (eg, from the synaptic cleft), and modulate one or more monoamine transporters. The present invention also provides pharmaceutical preparations comprising the compound.
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Description

[0001] This application is a divisional application of the application dated December 15, 2009, the application number is 200980156733.1, and the invention name is "triple reuptake inhibitor and its application method".

[0002] This application claims priority to US Provisional Application No. 61 / 138,062, filed December 16, 2008, the entire contents of which are incorporated herein by reference. 1. Technical field

[0003] The present invention provides compounds useful as triple reuptake inhibitors, compositions comprising the compounds, and methods of using them. 2. Background technology

[0004] Monoamine neurotransmitters have been found to be involved in the body's response to neurological disorders such as pain and depression. Norepinephrine (NE) and serotonin (5-HT) are monoamine neurotransmitters produced in the brain and diffuse throughout the central nervous system. 5-HT and NE have been reported to be involved in regulating the transmission of pain from the spin...

Claims

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