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Use of mimecan in the assessment of heart failure

一种心力衰竭、用途的技术，应用在mimecan在评价心力衰竭中的用途领域，能够解决不够等问题

Active Publication Date: 2016-05-04
F HOFFMANN LA ROCHE & CO AG
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0033] However, for many other aspects of diagnosis, a single marker is not sufficient

Method used

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  • Use of mimecan in the assessment of heart failure
  • Use of mimecan in the assessment of heart failure
  • Use of mimecan in the assessment of heart failure

Examples

Experimental program
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Embodiment Construction

[0042] In a first embodiment, the invention relates to a method of assessing heart failure in an individual comprising the steps of: a) measuring the concentration of labeled mimecan in a sample obtained from the individual, b) optionally measuring in the sample one or Concentrations of various other markers of heart failure, and c) concentrations of said one or more markers determined by comparing the concentrations measured in step (a) and optionally step (b) to a control sample comparison to assess heart failure.

[0043] In this document, each of the following terms has the meaning associated with it in this section.

[0044] The articles "a" or "an" are used herein to refer to one or more than one (ie at least one) of the grammatical object of the article. For example, "an antibody" means one antibody or more than one antibody.

[0045] The expression "one or more", "one or more" means 1 to 50, preferably 1 to 20, also preferably 2, 3, 4, 5, 6, 7, 8, 9, 10, 12 or 15.

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PUM

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Abstract

The invention relates to a method for assessing heart failure in vitro comprising the steps of measuring in a sample the concentration of the marker mimecan, of optionally measuring in the sample the concentration of one or more other marker(s) of heart failure selected from the group consisting of a natriuretic peptide marker, a cardiac troponin marker, and a marker of inflammation, and of assessing heart failure by comparing the concentration determined in for mimecan and the concentration(s) determined for the optionally one or more other marker to the concentration of this marker or these markers as established in a reference population. Also disclosed are the use of mimecan as a marker protein in the assessment of heart failure, a marker combination comprising mimecan and a kit for measuring mimecan.

Description

[0001] This application is a PCT application with an international filing date of July 23, 2010, an international application number of PCT / EP2010 / 004521, a national phase application number of 201080029136.5, and an invention title of "Use of mimecan in the evaluation of heart failure" Divisional application. technical field [0002] The present invention relates to a method of assessing heart failure in an individual comprising the steps of: a) measuring the concentration of the marker mimecan in a sample obtained from the individual, b) optionally measuring the concentration of one or more other heart failure markers in the sample , and assessing heart failure by comparing the concentration determined in step (a) and optionally the concentration determined in step (b) with the concentration of said one or more markers established in a control sample. Also disclosed are uses of mimecan as a marker protein to assess heart failure, marker combinations including mimecan, and ki...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N33/68
CPCG01N33/6893G01N2800/325G01N2333/4703G01N33/6812
Inventor D.布洛克S.阿拉布G.黑斯H.许迪希P.刘U-H.魏因许斯-特伦
Owner F HOFFMANN LA ROCHE & CO AG
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