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A liquid preparation for calcium supplementation and its preparation method

A liquid preparation and solution technology, applied in the application, the function of food ingredients, peptide/protein ingredients, etc., can solve the problems of unfavorable children, elderly people or patients, low effective content of calcium glycinate, easy disintegration of active ingredients, etc. Achieve the effect of calcium supplementation for children, great application value and high content of active ingredients

Active Publication Date: 2018-12-11
聪睿慧康(北京)科技发展有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] However, there are few studies on preparing calcium supplement products containing calcium glycinate into liquid preparations, and the preparation process is difficult to realize. Although it is prepared into liquid preparations, the effective content of calcium glycinate is still low, resulting in a large dosage, which is not conducive to children and children. Taking it by the elderly or patients with dysphagia, the preparation of high-content calcium glycinate liquid preparations has the disadvantages of difficult temperature control and easy disintegration of active ingredients during processing

Method used

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  • A liquid preparation for calcium supplementation and its preparation method
  • A liquid preparation for calcium supplementation and its preparation method
  • A liquid preparation for calcium supplementation and its preparation method

Examples

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Comparison scheme
Effect test

Embodiment 1

[0023] A liquid preparation for calcium supplementation, comprising the following components in parts by weight:

[0024]

[0025] The liquid preparation is any one of oral drops, oral liquid or beverage.

[0026] A preparation method for a liquid preparation for calcium supplementation, comprising the following steps: taking 30% by mass of erythritol, 0.1% of polydextrose and 0.1% of aspartame, adding water and fully stirring Dissolving to obtain solution A, respectively getting 0.1% potassium sorbate and 1.0% citric acid to dissolve in water respectively to obtain solution B and solution C, adding 3% calcium glycinate in solution A, and raising the temperature to 80 Keep at ℃ for 30 minutes, then add solution B and solution C to it, mix well to obtain a mixed solution, add 0.01% essence by mass percentage, 10% sodium carboxymethyl cellulose to the mixed solution, and add water to make up to 100 %, heated to 100°C and kept for 10 minutes, measured pH value was 3.6 to 4.6,...

Embodiment 2

[0028] A liquid preparation for calcium supplementation, comprising the following components in parts by weight:

[0029]

[0030] The liquid preparation is any one of oral drops, oral liquid or beverage.

[0031] A method for preparing a liquid preparation for calcium supplementation, comprising the following steps: taking 20% ​​erythritol, 0.2% polydextrose and 0.08% aspartame in water and fully stirring Dissolving to obtain solution A, respectively getting 0.2% potassium sorbate and 0.8% citric acid to dissolve in water to obtain solution B and solution C respectively, adding 4% calcium glycinate and 0.05% calcium glycinate in solution A Calcium citrate, 0.5% calcium sulfate and 0.05% calcium acetate, heated up to 85°C and kept for 30min, then added solution B and solution C to it, and mixed thoroughly to obtain a mixed solution, adding 0.02% by mass to the mixed solution % essence, 8% sodium carboxymethyl cellulose, add water to make up to 100%, heat to 100°C for 12 mi...

Embodiment 3

[0033] A liquid preparation for calcium supplementation, comprising the following components in parts by weight:

[0034]

[0035] The liquid preparation is any one of oral drops, oral liquid or beverage.

[0036]A method for preparing a liquid preparation for calcium supplementation, comprising the following steps: taking 18% by mass of erythritol, 0.3% of polydextrose and 0.07% of aspartame, adding water and fully stirring Dissolve to obtain solution A, get respectively the potassium sorbate of 0.3% and the citric acid of 0.5% to add water and dissolve respectively in mass percentage, obtain solution B, solution C, add the calcium glycinate that mass percentage is 6% in solution A, be warming up to 90 Keep at ℃ for 30 minutes, then add solution B and solution C to it, mix well to obtain a mixed solution, add 0.05% essence by mass percentage, 7% sodium carboxymethyl cellulose to the mixed solution, and add water to make up to 100 %, heated to 100°C and kept for 18 minutes...

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Abstract

The invention relates to health care products, in particular to a liquid preparation for calcium supplementation and a preparation method thereof. The liquid preparation for calcium supplementation includes the following components by mass percentage: 3-10% of calcium glycinate, 10-30% of erythritol, 0.1-0.5% of polydextrose, 0.01-0.1% of aspartame, 0.1-0.5% of potassium sorbate, 0.1-1.0% of citric acid, 0.01-0.1% of essence, 1-10% of sodium carboxymethyl cellulose, and the balance water. The invention provides a liquid preparation for calcium supplementation and a preparation method thereof. The content of calcium glycinate effective components can reach 60mg / ml maximumly, so that the liquid preparation is convenient for children and the elderly or patients with dysphagia to take orally, can effectively realize calcium supplementation to children, increases the bone mineral density in the elderly, does not generate calculus in clinical pharmacological experiments, and has stable blood calcium level, good tolerance and no adverse reaction.

Description

technical field [0001] The invention relates to health products, in particular to a liquid preparation for calcium supplementation and a preparation method thereof. Background technique [0002] Calcium content in a normal human body is 1200-2400g, accounting for about 1.5%-2.0% of the body mass. It is the most mineral element in the human body, 99% of which is in bones and teeth, and the other 1% is distributed in soft tissues, plasma and extracellular fluid . Calcium plays an important role in maintaining the normal physiological functions of human circulation, breathing, nerve, endocrine, digestion, blood, muscle, bone, urinary, immune and other systems, especially in the formation of myocardial action points. For example, regulating heart fluctuations; maintaining muscle contraction and transmission of nerve impulses; stimulating platelets, promoting blood coagulation on wounds, and many enzymes in the body require calcium activation. It can be seen that calcium plays a...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/195A23L33/10A23L33/16A23L33/17A23L29/30
CPCA23V2002/00A23V2200/30A23V2250/032A23V2250/1578A23V2250/2482A23V2250/6402
Inventor 张伟张睿哲
Owner 聪睿慧康(北京)科技发展有限公司