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Genes for prognosis of triple negative breast cancer and application thereof

A triple-negative breast cancer and gene technology, applied in the field of genes and their applications, can solve problems such as difficulty in acquisition, analysis efficiency and practical application limitations, and large restrictions on widespread application

Active Publication Date: 2016-10-05
FUDAN UNIV SHANGHAI CANCER CENT +1
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AI Technical Summary

Problems solved by technology

Due to the existence of too many genes with unknown functions, there are great limitations in analysis efficiency and practical application, and there are relatively large restrictions on its wide application.
Moreover, the samples required by Mammaprint are difficult to obtain clinically, and fresh and frozen samples are required, which further limits clinical application

Method used

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  • Genes for prognosis of triple negative breast cancer and application thereof
  • Genes for prognosis of triple negative breast cancer and application thereof
  • Genes for prognosis of triple negative breast cancer and application thereof

Examples

Experimental program
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Embodiment Construction

[0049] In this embodiment, the Chinese breast cancer population is taken as the research object, and the breast cancer pathological tissue is used as the sample, and the following experiments are carried out with the multiple parallel detection liquid gene chip tool.

[0050] Among them, the reagents used in the following experiments are commercial reagents unless otherwise specified.

[0051] In addition, all the breast cancer tissue samples were from breast cancer patients with operable breast cancer admitted to the Department of Breast Surgery, Cancer Hospital Affiliated to Fudan University, and the pathological stage was T 1-2 N 0-1 Early breast cancer, determined as breast invasive cancer specimens, whose immunohistochemical ER and PR are negative, and HER21+ or 2+ Fish test is negative. Combined with the work of prognostic gene groups in early breast cancer, 10-fold cross validation was used to select and evaluate the models. The purpose of using cross-validation is to...

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Abstract

The invention discloses genes for prognosis of triple negative breast cancer and the application thereof. The genes include gene GSTM1, gene BAG1, gene CD68, gene HDGFRP3, gene MAOB and gene TMEFF2. The genes can be applied to a multi-parallel testing liquid-phase gene chip for prognosis of triple negative breast cancer, a kit for prognosis of triple negative breast cancer, and a gene evaluation system for prognosis of triple negative breast cancer. By the adoption of the genes, accurate prognosis and classification of the relapse conditions of early-stage triple negative breast cancer patients in China five years after surgery can be achieved, and clinical medication can be effectively and timely guided.

Description

technical field [0001] The invention relates to a gene and its application, in particular to a group of genes used for the prognosis of early triple-negative breast cancer and its application. Background technique [0002] Breast cancer is the most common malignancy and cause of death among women worldwide. With the development of my country's economy and the change of lifestyle, the incidence of breast cancer in China, especially in developed cities, shows a rapid upward trend (5% per year), and the annual number of new cases is close to 180,000. In megacities such as Shanghai, breast cancer has leapt to the top of the incidence rate of female malignant tumors. Due to the improvement of people's awareness of screening and the improvement of diagnosis and treatment, the mortality rate of breast cancer has decreased, and the 5-year survival rate of early breast cancer is as high as 90%. [0003] Triple-negative breast cancer (TNBC) refers to a special type of breast cancer ...

Claims

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Application Information

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IPC IPC(8): C12Q1/68G06F19/00
Inventor 邵志敏黄晓燕徐晓晶
Owner FUDAN UNIV SHANGHAI CANCER CENT
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