Herba balanophorae involucratae extract and application thereof to preparation of anticancer medicine

An extract, Wenwang's technology, applied in the field of Wenwang Yibi extract and its application in the preparation of anticancer drugs

Active Publication Date: 2018-03-06
CHINA THREE GORGES UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, so far, Chinese herbal medicine has not become the drug of choice for the treatment of ovarian cancer and other malignant tumors at home and abroad. An important research task of

Method used

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  • Herba balanophorae involucratae extract and application thereof to preparation of anticancer medicine
  • Herba balanophorae involucratae extract and application thereof to preparation of anticancer medicine
  • Herba balanophorae involucratae extract and application thereof to preparation of anticancer medicine

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Experimental program
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Embodiment 1

[0029] Drug Extraction and Preparation

[0030] Take a Wenwang medicinal material, chop or crush it, use water as a solvent, heat and reflux extraction, the number of extractions is 3 times, 2 hours each time, the amount of solvent is 10 times the weight of the medicinal material each time, filter, and the extract is added The solvent was collected, concentrated, filtered and constant volume. At this time, the relative density of the liquid medicine at room temperature is 1.15.

[0031] Take the above medicinal solution, and gradually add 85% ethanol under the condition of heat preservation and stirring at 50°C, so that the final alcohol concentration of the medicinal solution system is 45%. Then, it was left to stand at a low temperature of 6° C. for 24 hours, and the supernatant and the precipitate were separated.

[0032] Part of the supernatant was taken out, and after recovering the ethanol under reduced pressure, it was concentrated and dried to obtain the extract (Frs...

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Abstract

The invention provides a herba balanophorae involucratae extract. The extract is an extract of an alcohol-soluble substance position obtained after herba balanophorae involucratae is subjected to water extraction and then is subjected to alcohol precipitation treatment or an extract of an ethyl-acetate position obtained after a supernatant solution, which is obtained after the herba balanophorae involucratae is subjected to the water extraction and then is subjected to the alcohol precipitation treatment, is abstracted through ethyl acetate or an extract of a water-extracted and alcohol-precipitated position obtained after a precipitate, which is obtained after the herba balanophorae involucratae is subjected to the water extraction and then is subjected to the alcohol precipitation treatment, is washed through alcohol and dried. According to the herba-balanophorae-involucratae extract, the herba-balanophorae-involucratae extract is applied to the preparation of a medicine for treatingan ovarian cancer and shown by an experiment, the herba-balanophorae-involucratae extract can be used for inhibiting the growth of A2780 and SKOV3 cells for the ovarian cancer in vitro in a dose-dependent manner, can be used for obviously inhibiting the growth of an A2780 nude-mice transplantation tumor in vivo and has a better effect.

Description

technical field [0001] The invention provides a variety of extracts of Wenwang Yibi, and the extracts are applied to medicines for treating ovarian cancer. Background technique [0002] Malignant tumors have always been a common and frequently-occurring disease that seriously threatens human health. According to the 2015 CA journal statistics in "2012 Global Cancer Statistics", there were approximately 14.1 million new cancer cases worldwide in 2012, and 8.2 million patients died of cancer. [0003] Ovarian cancer is one of the most common malignant tumors that endanger the health of women. Its incidence rate is second only to cervical cancer and uterine body cancer. However, the number of deaths due to ovarian cancer accounts for the first among all kinds of gynecological tumors, which seriously affects women's lives. threaten. The early symptoms of ovarian cancer are not typical, and early diagnosis is difficult; in addition, ovarian cancer has a strong ability to invade...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/185A61P35/00
CPCA61K36/185A61K2236/331A61K2236/333
Inventor 袁成福何毓敏刘正泰
Owner CHINA THREE GORGES UNIV
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