Anti-freezing and multi-emulsification gel composition and application

A technology for emulsifying gels and compositions, applied in cosmetics, emulsion delivery, cosmetic preparations, etc., can solve problems such as large damage to the gel structure, damage to the oil-water interface, and collapse and coarsening of the structure, achieving great practical significance and wide application Application prospect, effect of wide applicability

Active Publication Date: 2018-03-23
上海万相合一化妆品有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] However, the freezing process often damages the gel structure greatly, and it is easy to cause the gel to separate out of water, resulting in the structure collapsing and thickening, and the skin feeling becomes poor.
At the same time, the internal water phase of ordinary multiple emulsions produces ice crystals during the freezing process, which will destroy the oil-water interface, resulting in the aggregation of the internal water phase and a decrease in stability.
Therefore, the prior art lacks the antifreeze multiple emulsification gel applicable to the skin application field. If a related formula composition can be developed, it will have a stable W / O / W microstructure and meet the needs of freezing processing. important practical significance

Method used

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  • Anti-freezing and multi-emulsification gel composition and application
  • Anti-freezing and multi-emulsification gel composition and application
  • Anti-freezing and multi-emulsification gel composition and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] Example 1: Preparation method of antifreeze multiple emulsifying gel composition

[0033] (1) Weigh glycerin, carrageenan, and gellan gum, add them to water, heat to fully swell, add soluble divalent salt, hydrophilic emulsifier, and mix well to form the external phase gel mother liquor.

[0034] (2) Weigh the solid oil, add lipophilic emulsifier, and heat it in a water bath until it melts completely, which is the mother liquid of the middle oil phase.

[0035] (3) The internal water phase is added to the mother liquor of the middle oil phase and emulsified by a homogenizer to obtain a W / O emulsion.

[0036] (4) The W / O emulsion is added to the external phase gel mother liquor and stirred to obtain the gel type W / O / W multiple emulsion mother liquor.

[0037] (5) The mother liquor of multiple emulsions is poured into the mold, completely frozen, demolded, and restored to room temperature, that is, multiple emulsion gels (or gel-type multiple emulsions).

[0038] Freeze-re-thaw wate...

Embodiment 2

[0041] Example 2: Performance comparison of different multiple emulsions

[0042] Sample 1, the antifreeze multiple emulsion gel of the present invention: (1) Weigh 90 g of glycerin, 3 g of carrageenan, 0.5 g of gellan gum, and 905.5 g of water, and heat to fully swell; weigh 1.2 g of calcium chloride and Tween -8030g, add and stir evenly, it is the mother liquor of the external phase gel; (2) Weigh 60g of shea butter, add 6g of Span-80, add and melt, it is the mother liquor of the middle oil phase; (3) Drop 30g into the middle layer The oil phase mother liquor was homogenized at 5000rpm for 10min to obtain the W / O emulsion; (4) The W / O emulsion was added to the external phase gel mother liquor and stirred at 1000rpm for 10min to obtain the gel type W / O / W multiple emulsion mother liquor; (5) 20g of the mother liquor of multiple emulsions, cooled to 4°C, ready for use; (6) Pour the mother liquor of multiple emulsions into a spherical mold, 20g each, and freeze completely at -80°C ...

Embodiment 3

[0052] Example 3: Preparation of rose flower-shaped multiple emulsifying gel

[0053] Table 1: Formulation of the external phase of the gel

[0054] raw material name

[0055] (1) Weigh glycerin, carrageenan, gellan gum, and water according to the formula, and heat until fully swelled; weigh calcium chloride and Tween-8030g according to the formula, add and stir evenly to form the external phase gel mother liquor; (2) Weigh 60g of shea butter, add 6g of Span-80, and melt into the middle oil phase mother liquor; (3) Drop 30g into the middle oil phase mother liquor, homogenize at 5000rpm for 10min to obtain W / O emulsion; (4) ) Add the W / O emulsion to the external phase gel mother liquor, stir at 1000 rpm for 10 minutes to obtain the gel-type W / O / W multiple emulsion mother liquor; (5) Pour the multiple emulsion mother liquor into the rose silica gel mold and freeze completely at -80°C; (6) ) Demoulding and returning to room temperature naturally to obtain a rose-shaped multiple em...

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PUM

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Abstract

The invention provides an anti-freezing and multi-emulsification gel composition and application. The composition is of a W / O / W structure; the composition takes gel composed of water, glycerol, carrageenan, gellan gum and soluble divalent salt as an outer phase, room-temperature solid-state plant oil as a middle oil phase and water as an inner phase. The inner water phase of the composition provided by the invention can bear a water-soluble active substance; the middle-layer oil phase can bear an oil-soluble active substance; the gel of the outer water phase and the middle-layer oil phase haveno liquidity, so that compared with traditional W / O / W multi-emulsion, the composition is more stable and the change of grain diameters before and after freezing is small; meanwhile, the composition is composed of the special gel, so that the composition has extremely less freezing-re-melting separated water and a fine and smooth skin feeling. Therefore, the composition provided by the invention not only has an excellent active substance bearing capability, but also can support low-temperature processing and is used for preparing fine structures including flowers and the like; appearance innovation of skin-care and transdermal drug delivery products is realized and the anti-freezing and multi-emulsification gel composition has important realistic significance.

Description

Technical field [0001] The present invention mainly relates to the field of skin care and transdermal drug delivery products. Specifically, the present invention relates to the technical field of multiple emulsions and gels for skin care and transdermal drug delivery products. Background technique [0002] Multiple emulsion is a thermodynamically unstable system made by re-emulsification on the basis of single emulsion. Because it is a special multi-phase system with good tolerance, it can carry water-soluble drugs, fat-soluble drugs, and substances with a certain degree of solubility in oil and water, so it is of great significance in pharmacy. . In the field of skin care, multiple emulsions have also received more and more attention in recent years. For example, Zeng Lanlan et al. tried to use multiple emulsion technology to encapsulate vitamin C and sunscreen to improve the stability of these substances (Zeng Lanlan. Research on the preparation of multiple emulsions and thei...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/113A61K8/06A61K47/44A61K8/92A61K8/73A61K47/36A61K47/02A61K8/19A61Q19/00
CPCA61K8/066A61K8/19A61K8/73A61K8/922A61K9/113A61K47/02A61K47/36A61K47/44A61K2800/10A61Q19/00
Inventor 白焱晶范建礼
Owner 上海万相合一化妆品有限公司
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