A kind of antifreeze multiple emulsification gel composition and use

A technology for emulsifying gels and compositions, which is applied in the fields of cosmetics, emulsion delivery, dressing preparations, etc. It can solve the problems of large damage to the gel structure, damage to the oil-water interface, and collapse and coarsening of the structure, achieving great practical significance. Wide application prospects and wide applicability effects

Active Publication Date: 2021-01-08
上海万相合一化妆品有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] However, the freezing process often damages the gel structure greatly, and it is easy to cause the gel to separate out of water, resulting in the structure collapsing and thickening, and the skin feeling becomes poor.
At the same time, the internal water phase of ordinary multiple emulsions produces ice crystals during the freezing process, which will destroy the oil-water interface, resulting in the aggregation of the internal water phase and a decrease in stability.
Therefore, the prior art lacks the antifreeze multiple emulsification gel applicable to the skin application field. If a related formula composition can be developed, it will have a stable W / O / W microstructure and meet the needs of freezing processing. important practical significance

Method used

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  • A kind of antifreeze multiple emulsification gel composition and use
  • A kind of antifreeze multiple emulsification gel composition and use
  • A kind of antifreeze multiple emulsification gel composition and use

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] Embodiment one: the preparation method of antifreeze multiple emulsion gel composition

[0033] (1) Weigh glycerin, carrageenan, and gellan gum, add water, heat to fully swell, add soluble divalent salt, hydrophilic emulsifier, mix evenly, and become the external phase gel mother liquor.

[0034] (2) Weigh the solid oil, add lipophilic emulsifier, and heat in a water bath until completely melted to become the mother liquor of the middle oil phase.

[0035] (3) The inner water phase is added to the mother liquor of the middle oil phase, and emulsified by a homogenizer to obtain a W / O emulsion.

[0036] (4) W / O emulsion is added to the external phase gel mother liquor, and stirred to obtain a gel-type W / O / W multiple emulsion mother liquor.

[0037] (5) The multiple emulsion mother liquor is poured into the mold, completely frozen, demoulded, and returned to room temperature, and the multiple emulsion gel (or gel-type multiple emulsion) is obtained.

[0038] Comparison o...

Embodiment 2

[0041] Embodiment two: the performance comparison of different multiple emulsions

[0042]Sample 1, the antifreeze multiple emulsion gel of the present invention: (1) Weigh 90g of glycerin, 3g of carrageenan, 0.5g of gellan gum, and 905.5g of water, and heat to fully swell; weigh 1.2g of calcium chloride, Tween -8030g, add and stir evenly, it is the mother liquid of the outer phase gel; (2) Weigh 60g of shea butter, add 6g of Span-80, add and melt, it is the mother liquid of the middle oil phase; (3) drop 30g of water into the middle layer Oil phase mother liquor, homogenized at 5000rpm for 10min to obtain W / O emulsion; (4) Add W / O emulsion to external phase gel mother liquor and stir at 1000rpm for 10min to obtain gel type W / O / W multiple emulsion mother liquor; (5) 20g of the multiple emulsion mother liquor, cooled to 4°C, and set aside; (6) Pour the multiple emulsion mother liquor into spherical molds, 20g each, and freeze completely at -80°C, set aside.

[0043] Sample 2, ...

Embodiment 3

[0052] Embodiment three: the preparation of the multiple emulsification gel of rose shape

[0053] Table 1: Gel external phase formula table

[0054] raw material name mass, g water 893.3 glycerin 100 carrageenan 6 gellan gum 0.2 calcium chloride 0.5

[0055] (1) Glycerin, carrageenan, gellan gum, and water are weighed according to the formula, and heated to fully swell; Calcium chloride, Tween-8030g are weighed according to the formula, added and stirred evenly, to be the external phase gel mother liquor; (2) Weigh 60g of Shea Butter, add 6g of Span-80, add and melt to form the mother liquid of the middle oil phase; (3) drop 30g of water into the mother liquid of the middle oil phase, homogenize at 5000rpm for 10min, and obtain a W / O emulsion; (4 ) Add the W / O emulsion to the external phase gel mother liquor, and stir at 1000rpm for 10 minutes to obtain a gel-type W / O / W multiple emulsion mother liquor; (5) pour the multiple emuls...

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Abstract

The invention provides an anti-freezing and multi-emulsification gel composition and application. The composition is of a W / O / W structure; the composition takes gel composed of water, glycerol, carrageenan, gellan gum and soluble divalent salt as an outer phase, room-temperature solid-state plant oil as a middle oil phase and water as an inner phase. The inner water phase of the composition provided by the invention can bear a water-soluble active substance; the middle-layer oil phase can bear an oil-soluble active substance; the gel of the outer water phase and the middle-layer oil phase haveno liquidity, so that compared with traditional W / O / W multi-emulsion, the composition is more stable and the change of grain diameters before and after freezing is small; meanwhile, the composition is composed of the special gel, so that the composition has extremely less freezing-re-melting separated water and a fine and smooth skin feeling. Therefore, the composition provided by the invention not only has an excellent active substance bearing capability, but also can support low-temperature processing and is used for preparing fine structures including flowers and the like; appearance innovation of skin-care and transdermal drug delivery products is realized and the anti-freezing and multi-emulsification gel composition has important realistic significance.

Description

technical field [0001] The present invention mainly relates to the field of skin care and transdermal drug delivery products, in particular, the present invention relates to the technical field of multiple emulsions and gels of skin care and transdermal drug delivery products. Background technique [0002] Multiple emulsions are thermodynamically unstable systems made by re-emulsifying on the basis of single emulsions. Because it is a special multi-phase system with good tolerance, it can carry not only water-soluble drugs, but also fat-soluble drugs, and substances with certain solubility in oil and water, so it is of great significance in pharmacy . In the field of skin care, multiple emulsions have also received increasing attention in recent years. For example, Zeng Lanlan and others tried to wrap vitamin C and sunscreen with multiple emulsion technology to improve the stability of these substances (Zeng Lanlan. Research on the preparation of multiple emulsions and the...

Claims

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Application Information

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Patent Type & AuthorityPatents(China)
IPC IPC(8): A61K9/113A61K8/06A61K47/44A61K8/92A61K8/73A61K47/36A61K47/02A61K8/19A61Q19/00
CPCA61K8/066A61K8/19A61K8/73A61K8/922A61K9/113A61K47/02A61K47/36A61K47/44A61K2800/10A61Q19/00
Inventor白焱晶范建礼
Owner上海万相合一化妆品有限公司