Application of FOXM1 inhibitor to treatment of intrahepatic cholangiocarcinoma

A technology for cholangiocarcinoma and cholangiocarcinoma, applied in the direction of medical preparations containing active ingredients, tripeptide components, instruments, etc., can solve the sensitivity and poor prognosis of patients with intrahepatic cholangiocarcinoma, and the prognosis of patients with intrahepatic cholangiocarcinoma The role of limited, poor treatment effect and other problems

Inactive Publication Date: 2018-07-13
ZHEJIANG UNIV
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Problems solved by technology

However, this treatment regimen has limited effect on improving the prognosis of patients with intrahepatic cholangiocarcinoma
Moreover, the genetic variation of intrahepatic cholangiocytes is highly heterogeneous, making it impossible to find specific targeted therapeutic drugs
So far, the largest multi-center clinical study found that patients with intrahepatic cholangiocarcinoma have poor sensitivity and prognosis to GP chemotherapy, and the treatment effect is not good

Method used

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  • Application of FOXM1 inhibitor to treatment of intrahepatic cholangiocarcinoma
  • Application of FOXM1 inhibitor to treatment of intrahepatic cholangiocarcinoma
  • Application of FOXM1 inhibitor to treatment of intrahepatic cholangiocarcinoma

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Experimental program
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Embodiment 1

[0138] 1. Experimental route

[0139] (1) The expression of FOXM1 in intrahepatic cholangiocarcinoma:

[0140] The mRNA of 20 ICC patients' tumor tissues and paired frozen specimens of adjacent tissues were extracted, and their paraffin samples of tumor and adjacent tissues were collected. Real-time fluorescence quantitative PCR, immunohistochemistry and other techniques were used to verify the expression of FOXM1 in ICC tumor tissues and adjacent tissues. expression of the organization. In addition, tissue microarrays of tumor tissues from 91 patients with intrahepatic cholangiocarcinoma and 21 normal human liver tissues were analyzed by immunohistochemistry.

[0141](2) Prognosis analysis: According to the results of immunohistochemistry, the relationship between FOXM1 and the clinicopathological features and prognosis of patients with intrahepatic cholangiocarcinoma was explored.

[0142] (3) The expression of FOXM1 is closely related to the drug sensitivity to cisplatin:...

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Abstract

The invention belongs to the technical field of medicine. Through wide and deep research finds that, FOXM1 performs high expression in cholangiocarcinoma and is related to prognosis, the FOXM1 inhibitor inhibits proliferation of cholangiocarcinoma by increasing apoptosis, the FOXM1 knocks down to improve the sensitivity of the cholangiocarcinoma on cis-platinum, and the FOXM1 inhibitor is combinedwith the cis-platinum to inhibit proliferation of the cholangiocarcinoma. As a result, the FOXM1 plays an important role in the generation and development processes of the cholangiocarcinoma and provides new thought for diagnosis and treatment of the cholangiocarcinoma.

Description

technical field [0001] The invention belongs to the technical field of medicine, and specifically relates to the effect of FOXM1 inhibitors in the treatment of intrahepatic cholangiocarcinoma. Background technique [0002] Cholangiocarcinomas (CCAs) are a class of malignant tumors derived from the biliary epithelium with the differentiation properties of cholangiocytes. According to the different anatomical location, it can be divided into intrahepatic cholangiocarcinoma (ICC), hilar cholangiocarcinoma and extrahepatic cholangiocarcinoma (ECC). The overall incidence of intrahepatic cholangiocarcinoma has gradually increased globally over the past four decades. At present, the main method for intrahepatic cholangiocarcinoma is surgical treatment. However, for patients who cannot undergo radical resection or have metastases in surrounding tissues and organs, the chemotherapy regimen of cisplatin combined with gemcitabine (also called GP chemotherapy regimen) is clinically us...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K45/00A61K45/06A61K33/24A61K38/06A61P35/00G01N33/574
CPCA61K33/24A61K38/06A61K45/00A61K45/06G01N33/57407G01N2333/4704G01N2800/08A61K2300/00
Inventor 陈迪宇吴健戴龙飞刘华
Owner ZHEJIANG UNIV
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