Application of FOXM1 inhibitor to treatment of intrahepatic cholangiocarcinoma
A technology for cholangiocarcinoma and cholangiocarcinoma, applied in the direction of medical preparations containing active ingredients, tripeptide components, instruments, etc., can solve the sensitivity and poor prognosis of patients with intrahepatic cholangiocarcinoma, and the prognosis of patients with intrahepatic cholangiocarcinoma The role of limited, poor treatment effect and other problems
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[0138] 1. Experimental route
[0139] (1) The expression of FOXM1 in intrahepatic cholangiocarcinoma:
[0140] The mRNA of 20 ICC patients' tumor tissues and paired frozen specimens of adjacent tissues were extracted, and their paraffin samples of tumor and adjacent tissues were collected. Real-time fluorescence quantitative PCR, immunohistochemistry and other techniques were used to verify the expression of FOXM1 in ICC tumor tissues and adjacent tissues. expression of the organization. In addition, tissue microarrays of tumor tissues from 91 patients with intrahepatic cholangiocarcinoma and 21 normal human liver tissues were analyzed by immunohistochemistry.
[0141](2) Prognosis analysis: According to the results of immunohistochemistry, the relationship between FOXM1 and the clinicopathological features and prognosis of patients with intrahepatic cholangiocarcinoma was explored.
[0142] (3) The expression of FOXM1 is closely related to the drug sensitivity to cisplatin:...
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