48 results about "Intrahepatic bile ducts" patented technology

The invention discloses a new Chinese medicinal composition for treating the symptom of gallstones and a preparation method thereof. The Chinese medicinal composition mainly comprises the following raw material medicaments: pangolin scales, immature bitter orange, curcuma aromatica, green tangerine peel, chicken's gizzard-membrane, peach seed, safflower, common burreed rhizome, zedoary, rhizoma corydalis, frankincense, myrrh, dragon's blood, Chinese honeylocust spine, root of red-rooted salvia, sappan wood, dried lacquer, turtle shell, rhubarb, Chinese dwarf cherry seed, golden thread, honeysuckle, artemisia capillaries, longhairy antenoron herb, pantain seed, talc and Japanese climbing fern spore. The Chinese medicinal composition of the invention can be prepared into any common oral administration preparation according to the conventional method of Chinese medicinal preparations. The Chinese medicinal composition can improve symptoms such as pain, paroxysmal aggravation, abdominal distension, bitter taste, constipation, yellow urine, ictericsclera, yellow body and the like which are caused by gallstones obviously, call away the gallstones, bile duct stones and stones in intrahepatic bile ducts, and has the definite clinical curative effect and obvious curative effect on the treatment of cholecystitis. The Chinese medicinal composition has the advantages of low cost, no toxic or side effect basically and the like.

A double-tube type stent is inserted into a hollow tubular organ such as a bile duct so as to relieve narrowing of the bile duct on, for instance, an anastomotic area of the intrahepatic bile duct of a liver transplant patient. A hollow cylindrical body has a plurality of rhombic spaces formed by weaving a superelastic shape-memory-alloy wire so as to be crossed. A silicon coating layer is coated on an outer surface of the cylindrical body using a silicon solution. A polytetrafluoroethylene (PTFE) tube is fixedly fitted around the cylindrical body having the silicon coating layer leaving a gap therebetween.

The invention provides a remover for calculus of intrahepatic duct of hepatology. The remover comprises a rotation motor, a rotation shaft, a casing tube, a scraping net, and a collection bag. The rotation motor is connected with the rotation shaft; the rotation shaft is arranged in a rotation channel inside the casing tube; and the scraping net and the collection bag are arranged at the tail end of the rotation shaft, wherein the scraping net and the collection bag are disturbed in an ellipsoid shape. The scraping net is formed by a plurality of scraping knives distributed uniformly; and the coverage angel of the scraping net is one half of the ellipsoid. A plurality of micro holes are formed in the surface of the collection bag and the coverage angle of the collection bag is the other half of the ellipsoid. According to the invention, the remover with a simple structure can be used conveniently. With the rotation motor as well as the matched scraping net, collection bag, and the negative-pressure device, the calculus can be removed completely and effectively and the bile duct can be protected from being damaged. Meanwhile, when the calculus is removed, the blood attached to the calculus surface can be cleaned and the calculus and the blood clot can be separated.

The invention belongs to medical instruments, and in particular relates to a novel three-dimensional electronic choledochoscope system for reconfiguring a three-dimensional image by using a multi-CCD (Charge Coupled Device) array, which comprises a soft electronic choledochoscope, a processing host computer, a light source host computer and a work station assembly, wherein the processing host computer, the light source host computer and the work station assembly are connected with the soft electronic choledochoscope; the three-dimensional soft electronic cystoscope enters a gall bladder cavity through a small cut at the bottom of the gall bladder and can enter the biliary tract through a small cut on the bile duct wall, then turns into the bile duct through better flexibility and control, and then enters the common bile duct for detecting the condition of the common bile duct; the multi-CCD array module at the tip part of a choledochoscope working end part is used for finely scanning the common bile duct, even the intrahepatic bile duct to obtain a three-dimensional image of the choledochoscope cavity; and a doctor treats the gall bladder pathological change according to the three-dimensional image.

The invention belongs to the technical field of medicine. Through wide and deep research finds that, FOXM1 performs high expression in cholangiocarcinoma and is related to prognosis, the FOXM1 inhibitor inhibits proliferation of cholangiocarcinoma by increasing apoptosis, the FOXM1 knocks down to improve the sensitivity of the cholangiocarcinoma on cis-platinum, and the FOXM1 inhibitor is combinedwith the cis-platinum to inhibit proliferation of the cholangiocarcinoma. As a result, the FOXM1 plays an important role in the generation and development processes of the cholangiocarcinoma and provides new thought for diagnosis and treatment of the cholangiocarcinoma.

The invention provides a method for inducing directional endoderm stem cells to form intrahepatic bile duct-like cells. The method comprises the steps of directionally inducing directional endoderm stem cells to form liver directed endodermal cells, and differentiating the liver directed endodermal cells into human bile duct-like cells under directional action of a small molecular compound and theMAPK / PKC signaling pathway activator. The invention further provides human bile duct-like cells acquired through the method.

The invention discloses an intrahepatic stone extractor. The intrahepatic stone extractor comprises an operating rod. A control assembly and a clamping assembly are arranged in the operating rod. Theclamping assembly comprises two symmetrically-arranged clamps, the two clamps comprise clamping arms, clamping bodies and installing rings, the ends, close to the clamping bodies, of the two clampingarms are hinged to the installing rings, a closed clamping cavity is formed when the two clamping bodies are closed, a breaking device is arranged in the operating rod, and a driving device drives thebreaking device to stretch into the closed clamping cavity to break stones in the clamping bodies. The breaking device comprises a screw-shaped drill bit and a connecting rod, the drill bit is fixedly connected with the connecting rod, a locking assembly is arranged on the connecting rod, the locking assembly comprises multiple supporting arms, when the drill bit rotates, the ends, away from a hinge shaft, of the supporting arms are rotated to be radially diffused to be in supporting contact with the clamping arms, the state that the clamping arms are opened up is kept, and therefore it is avoided that in the stone breaking process of the drill bit, a gap is generated when the clamps are separated, and the small broken stones are separated out of the clamps.

The invention relates to a biliary tract support, which comprises tubular main body made from the material matched with body; the first protruded ring, the second protruded ring, and the extending part far away the second protruded ring, wherein the invention can avoid stitching match open, to save time, avoid directly function biliary tract match open with bile, without leakage, confirm enough blood supply, confirm successful flow of bile, and improve treatment effect.

The invention discloses a product and a method for identifying hepatocellular carcinoma and intrahepatic cholangiocarcinoma based on an MANF as a marker. The invention provides an application of a system for detecting the expression quantity of the MANF in preparation of products for identification or supplementary identification of hepatocellular carcinoma patients and intrahepatic cholangiocarcinoma patients. The hepatocellular carcinoma and the intrahepatic cholangiocarcinoma are identified by taking the MANF as the marker and detecting the expression level of the MANF in a primary hepatocellular carcinoma tissue, a method and an index for effectively identifying the hepatocellular carcinoma and the intrahepatic cholangiocarcinoma are built, the sensitivity is 92.5% and the specificity is 74.7%. A foundation is laid for targeted appropriate treatment and improvement of prognosis of the patients to improve the living quality of the patients and to reduce the economic burden of the patients.

The invention relates to Chinese medicinal decoction used for treating lithiasis and a preparation method thereof, and relates to Chinese medicinal decoction for treating biliary calculus and renal calculus diseases. Main components of the decoction comprise ophiorrhiza pumila, dandelion, rhizoma sparganii, zedoary, white paeony root, herba pyrrosiae, bupleurum, Szechuan lovage rhizome, peach kernel, radix curcumae, gizzard lining, curcuma, knotgrass, gardenia, dried old orange peel, immature tangerine peel, liquorice and the like. The Chinese medicinal decoction can effectively heal intrahepatic bile duct calculus after the gall bladder is extirpated and calcification and sand-like calculus in the kidney, and simultaneously can effectively promote choleresis, improve the self-healing function of the gall bladder, and recover the functions of the gall bladder and the kidney.

The invention discloses an expandable percutaneous drainage tube. The percutaneous drainage tube has the advantages that: 1, a sectional shape memory alloy reticular structure tube is arranged in a rubber tube, and can made radial expansion and axial shrinkage in the rubber tube, but the percutaneous drainage tube can be prevented from axially greatly shrinking; 2, after gall bladder or intrahepatic bile duct is subjected to percutaneous drainage, the expanded sinus tract can be directly subjected to therapeutic choledochoscopy by using the expandable percutaneous drainage tube, calculus is taken out to protect a patient from operating pain, and the expandable percutaneous drainage tube has less injury and is safe in comparison with an existing minimally invasive method; and 3, after a necrosis substance on the periphery of severe pancreatitis is subjected to percutaneous drainage, a conventional drainage tube is usually blocked by the necrosis substance, and the drainage effect is lost, but a thick drainage tube for first puncture faces a higher puncture risk. By using the expandable percutaneous drainage tube, smooth drainage of the drainage tube is benefited, and cleaning and other further treatments can be carried out through the sinus tract built-in endoscope appliance.

The invention relates to a choledochoscope for removing calculi from intrahepatic bile duct, the calculi from extrahepatic bile duct and postoperative residual calculi, keeping a gall bladder and taking out calculi of gall bladder in surgery (including endoscopic surgery and open surgery). The choledochoscope for removing calculi comprises a choledochoscope body, wherein a choledochoscope tip is formed at the first end of the choledochoscope body; the second end of the choledochoscope body is connected with a cold light source interface, a water inlet interface, a camera interface and an operation passage entrance; a hollow cavity structure is formed on the back part of the choledochoscope body; the hollow cavity structure is communicated with the cold light source interface, the water inlet interface, the camera interface and the operation passage entrance. Compared with the prior art, the choledochoscope for removing the calculi is connected with a camera through the camera interface, so that the choledochoscope for removing the calculi can treat the calculi in first-level, second-level and third-level bile ducts and even part of fourth-level bile ducts, and calculi in a common bile duct (particularly the middle lower section) and the gall bladder efficiently and quickly on a television screen or a computer screen through an operation passage and the calculi removal efficiency is high.

The invention relates to a traditional Chinese medicine for treating liver and gall lithiasis and a method for preparing the same. The traditional Chinese medicine is prepared from the following components in parts by weight: 7-12 parts of desmodium styracifolium, 8-10 parts of endothelium corneum gigeriae galli, 5-7 parts of peach kernel, 5-8 parts of carthamus tinctorious, 4-7 parts of salvia miltiorrhiza, 3-6 parts of angelica sinensis, 4-7 parts of rehmannia, 8-11 parts of bupleurum, 2-4 parts of pericarpium citri reticulatae viride, 5-8 parts of pangolin and 4-7 parts of liquorice. The traditional Chinese medicine is reasonable in formula, is convenient and safe to take, has no side and toxic effect and is clinically tested to be definite and significant in curative effect. The years of clinical observation shows that the traditional Chinese medicine has the efficacy of promoting the blood circulation to remove blood stasis, regulating qi, inducing diuresis and removing stones, can be used for treating ollateral obstruction caused by blood stasis, gallbladder lithiasis caused by qi stagnation and damp obstruction and hepatolithiasis with an effective rate of more than 98%, can be also used for reducing the postoperative residual stones, preventing the recurrence of lithiasis and relieving the suffering of a majority of patients, has significant effects on preoperative conditioning and postoperative consolidating and achieves good economic and social benefits.

The invention relates to a traditional Chinese medicine for treating liver and gall lithiasis and a method for preparing the same. The traditional Chinese medicine is prepared from the following components in parts by weight: 8-10 parts of bupleurum, 5-7 parts of curcuma aromatica, 6-9 parts of Sichuan Chinaberry fruit, 8-10 parts of rehmannia, 3-5 parts of Chinese wolfberry fruit, 3-6 parts of radix glehniae, 4-7 parts of angelica sinensis, 3-6 parts of white paeony root, 8-10 parts of desmodium styracifolium, 15-18 parts of capillary artemisia and 2-5 parts of rheum officinale. The traditional Chinese medicine is reasonable in formula, is convenient and safe to take, has no side and toxic effect and is clinically tested to be definite and significant in curative effect. The years of clinical observation shows that the traditional Chinese medicine has the efficacy of nourishing yin and the liver, reducing internal heat, diminishing inflammation, normalizing gallbladder and removing stones, can be used for treating live and yin deficiency, gallbladder lithiasis caused by internal damp heat and hepatolithiasis with an effect rate of more than 98%, reducing the postoperative residual stones, preventing the recurrence of lithiasis and relieving the suffering of a majority of patients, has significant effects on preoperative conditioning and postoperative consolidating and achieves good economic and social benefits.

The invention discloses an application of splenic tyrosine kinase as a therapeutic target for intrahepatic cholangiocarcinoma. Experiments find out that the expression of SYK in intrahepatic cholangiocarcinoma is increased. In-vitro cell and in-vivo animal experiments find out that the proliferation of intrahepatic cholangiocarcinoma can be effectively inhibited with the use of the SYK antagonistGS-9973, and the inhibiting effect is close to that of a first-line chemotherapeutic drug gemcitabine.

The invention relates to an intrahepatic bile duct coated stent and a use method thereof. The stent comprises a coated stent body; a local area of the side wall of the coated stent body is provided with a non-coated area which contains liquid substances, wherein the liquid substances can penetrate through and flow into an opening of the end portion of the coated stent body. The use method of the intrahepatic bile duct coated stent comprises the following steps that a, the coated stent body 11 sleeves a stent conveying device; b, the stent is implanted; c, the coated stent body 11 is released;d, the coated stent body 11 is drawn out by drawing a traction rope 14, and then the operation of breaking stone and removing the stone is conducted immediately. The stent has the advantages of beingsimple in structure, convenient to operate and the like.

The invention discloses a traditional Chinese medicine for treating calculus of intrahepatic bile duct. The traditional Chinese medicine comprises the following components in parts by weight: sovereign drugs: 150 parts of talc, 40 parts of endothelium corneum gigeriae galli, 40 parts of lysimachia christinae hance and 30 parts of oyster; minister drugs: 15 parts of bighead atractylodes rhizome, 15 parts of hawthorn, 12 parts of radix curcumae, 10 parts of sandalwood, 8 parts of fructus amomi, 12 parts of poncirus trifoliate, 20 parts of polygonum cuspidatum, 12 parts of szechwan Chinaberry fruit, 10 parts of rhizoma cyperi and 15 parts of radix bupleuri; assistant drugs: 30 parts of white paeony root, 30 parts of salvia miltiorrhiza, 12 parts of betelnut piece, 15 parts of rhizoma corydalis, 12 parts of pollen typhae, 15 parts of trogopterus dung, 15 parts of combined spicebush root and 15 parts of aspongopus; and courier drugs / medicines: 30 parts of oldenlandia diffusa, 30 parts of patrinia, 10 parts of dandelion, 30 parts of phaseolus calcaratus, 30 parts of keel, 15 parts of akebiaquinata, 30 parts of Japanese climbing fern, 30 parts of oriental wormwood and 15 parts of scutellaria baicalensis. The preparation method comprises the following steps: removing impurities and water out of the medicinal materials, repeatedly frying the medicinal materials in a cast iron pan until the medicinal materials are dried and crispy; crushing the medicinal materials by using a crusher, and sieving through a fine sieve. The traditional Chinese medicine has the effects of tonifying spleen, removing dampness to dredge channels, clearing heat, promoting diuresis to dredge liver and gall, promoting qi circulation and relieving pain to remove calculus.

The invention discloses a choledochoscope guider in laparoscopic surgery, and relates to the field of medical instruments. The choledochoscope guider comprises a first guide tube, wherein one end of the first guide tube is connected with a second guide tube, exterior of the first guide tube is movably sleeved with a laparoscope trocar, interior of the first guide tube and interior of the second guide tube are both communicated with choledochoscopes, a first threaded head is integrally formed in a middle section of exterior of the laparoscope trocar, the first threaded head is sleeved with a limiting cylinder, and the limiting cylinder is fixedly sleeved with a limiting plate. According to the choledochoscope guider, by means of an adjusting assembly, a user can conveniently adjust an expansion degree of an cylindrical airbag according to actual needs, so that the second guide tube is always located on an inner wall of the common bile duct, and the intrahepatic bile duct and the extrahepatic bile duct are fully expanded, in addition, the adjusting assembly is high in adjusting precision, and will not cause the cylindrical airbag to expand beyond the standard, thereby ensuring a clear vision.

The invention discloses a new Chinese medicinal composition for treating the symptom of gallstones and a preparation method thereof. The Chinese medicinal composition mainly comprises the following raw material medicaments: pangolin scales, immature bitter orange, curcuma aromatica, green tangerine peel, chicken's gizzard-membrane, peach seed, safflower, common burreed rhizome, zedoary, rhizoma corydalis, frankincense, myrrh, dragon's blood, Chinese honeylocust spine, root of red-rooted salvia, sappan wood, dried lacquer, turtle shell, rhubarb, Chinese dwarf cherry seed, golden thread, honeysuckle, artemisia capillaries, longhairy antenoron herb, pantain seed, talc and Japanese climbing fern spore. The Chinese medicinal composition of the invention can be prepared into any common oral administration preparation according to the conventional method of Chinese medicinal preparations. The Chinese medicinal composition can improve symptoms such as pain, paroxysmal aggravation, abdominal distension, bitter taste, constipation, yellow urine, ictericsclera, yellow body and the like which are caused by gallstones obviously, call away the gallstones, bile duct stones and stones in intrahepatic bile ducts, and has the definite clinical curative effect and obvious curative effect on the treatment of cholecystitis. The Chinese medicinal composition has the advantages of low cost, no toxicor side effect basically and the like.

The invention provides a lithotripsy basket catheter with a lithotripsy balloon. The lithotripsy basket catheter comprises a catheter e and a connecting rod type basket arranged in the catheter. The catheter comprises a first catheter section, a second catheter section and a third catheter section which are sequentially communicated; a balloon is arranged outside the second catheter section; and aballoon inflation channel and a basket connecting rod channel for displacement are arranged in the catheter. After calculi are taken by the basket, the basket is tightened, and the calculi can be fixed and tightly attached to the lithotripsy electrode at the head end of the catheter. After the balloon is filled, broken calculi can be prevented from entering an intrahepatic bile duct in the calculi breaking process. After the common bile duct calculi are crushed, the broken calculi can be dragged into the common bile duct by using the balloon, or after the common bile duct calculi are crushed,the broken calculi are dragged into the duodenum by using the balloon or the basket. By arranging the lithotripsy electrode, large common bile duct calculi can be subjected to plasma lithotripsy, microelectrode lithotripsy and laser lithotripsy under X-ray, choledochoscope assistance is not needed, and the lithotripsy basket catheter is more suitable for primary hospitals.

The invention discloses a rotatable duodenal papillotome. The rotatable duodenal papillotome comprises an outer sleeve, an outer sleeve handle and a papillotome, wherein the papillotome is located in the outer sleeve, the outer sleeve handle is arranged at one end of the outer sleeve, and the outer sleeve and the papillotome are in a gear shape. According to the rotatable duodenal papillotome, the metal outer sleeve is additionally arranged on the outer face of an original duodenal papillotome, has certain elasticity and tenacity and can drive the duodenal papillotome in the outer sleeve to rotate when rotating, in this way, when entering a gall bladder or left and right intrahepatic bile ducts, a duodenal papilla cannula or superselective guide wire can accurately rotate in the catheter direction to meet the requirement of surgical operation and increase the success rate of surgical operation. The rotatable duodenal papillotome has the advantages of being convenient to operate, high in success rate and suitable for application and popularization.

A Chinese medicine in the form of capsule, tablet, or particle for treating hepstolithiasis is prepared from 14 Chinese-medicinal materials including chicken's gizzard-skin, bitter orange, cyperus tuber, haw, etc. It features quickly taking its high curative effect.

The invention relates to a Chinese traditional medicine for treating gall-stone, which consists of Chinese herbal medicines of herba lysimachia, herb of virgate vormwood, radix curcuma, cape jasmine, chickens gizzard-skin and eucommia. The formula has functions of easing the liver and promoting the gallbladder and promoting circulation of qi and relieving pain and is used for costalgia caused by qi stasis; and when the medicine is used to treat patients with calculus of intrahepatic duct and gall-stone, the medicine has the advantages of good effect of removing urinary calculus, fast effect, short curing period, painlessness and no toxic and side effects.

The invention provides a reversed-a-shaped nasobiliary drainage tube. The drainage tube particularly is a single-channel pipe, and comprises a nasobiliary drainage tube head, a drainage part, a bent part and a leading-out part; the drainage part comprises a plurality of bile drainage holes; the reversed-a-shaped nasobiliary drainage tube is placed in a human body, the head of the nasobiliary drainage tube extends into a right hepatic duct, the bile drainage holes are close to the primary tube wall of a duodenum, and the bile drainage holes comprises middle holes and triangular holes connectedwith the middle holes and formed in the left sides and the right sides of the middle holes; the bent part is provided with a plurality of groups of bent corners to form a reverse a shape; and the leading-out part extends out of the human body and is connected with a drainage bag. Under the guide of a guide wire, the drainage tube can be easily placed into the intrahepatic bile duct through duodenal papilla, has a better anti-skid effect, is easy to pull out, and has small stimulation to the duodenal papilla.

The utility model discloses a metal stent drainage tube for percutaneous transhepatic duct puncture, and belongs to the technical field of medical instrument manufacturing. The device comprises a drainage tube, an outer sleeve, an inner sleeve, a puncture needle, a drainage tube connector and a dressing patch. The drainage tube is divided into a head part and a body part, and the head part is a metal stent woven by titanium alloy wires; the outer sleeve comprises a head, a body, a tail and a connecting wire, wherein the head is conical, an opening is formed in the head end, and a connecting wire passing hole is formed in the tail; threads are arranged on the surface of the tail end of the inner sleeve; the puncture needle is a metal needle, a plastic resistance block is arranged at the head end, a cap-shaped connector is arranged at the tail end, and threads are arranged on the inner wall of the cap-shaped connector for screwing the puncture needle at the tail end of the inner sleeve;the connector comprises an inner core and a cap, threads are arranged on the surface of the inner core, threads are arranged on the inner wall of the cap, and the cap is screwed on the inner core; thedressing patch is an annular non-woven fabric patch, and a cap-shaped structure is arranged in the middle of the dressing patch. The metal stent drainage tube has the advantages that the metal stentdrainage tube can be directly punctured into an intrahepatic bile duct, the metal stent is retained for supporting stenosis, and the metal stent can be taken out subcutaneously after the stenosis is removed.

The invention discloses a percutaneous intrahepatic bile duct-ascites shunt synchronous drainage tube. The drainage tube comprises a bile tube, the outer portion of the bile tube is sleeved with an ascites tube, two <-shaped branch tubes capable of being deformed by pulling of a pull wire are arranged at one end of the bile tube, the ends, away from the bile tube, of the two branch tubes are connected,and one end of the pull wire penetrates through the bile tube and one of the branch tubes and then penetrates through the bile tube to return to the outside of the drainage tube; a tube body of the ascites tube is provided with more than one compressible and extensible corrugated section, each corrugated section comprises a corrugated section A close to the section A of the bile tube and a corrugated section B close to a pipe opening of the ascites tube, and an ascites drainage opening is formed in the side wall of a corrugated piece of each corrugated section A; and a plurality of biliary drainage openings are formed in the section A of the bile tube and the branch tubes. The drainage tube is simple in structure, firm in fixation and flexible and convenient to use, and can achieve the function of simultaneously draining abdominal dropsy and bile by avoiding wounds caused by multiple punctures.

The invention belongs to medical instruments, and in particular relates to a novel three-dimensional electronic choledochoscope system for reconfiguring a three-dimensional image by using a multi-CCD (Charge Coupled Device) array, which comprises a soft electronic choledochoscope, a processing host computer, a light source host computer and a work station assembly, wherein the processing host computer, the light source host computer and the work station assembly are connected with the soft electronic choledochoscope; the three-dimensional soft electronic cystoscope enters a gall bladder cavity through a small cut at the bottom of the gall bladder and can enter the biliary tract through a small cut on the bile duct wall, then turns into the bile duct through better flexibility and control,and then enters the common bile duct for detecting the condition of the common bile duct; the multi-CCD array module at the tip part of a choledochoscope working end part is used for finely scanning the common bile duct, even the intrahepatic bile duct to obtain a three-dimensional image of the choledochoscope cavity; and a doctor treats the gall bladder pathological change according to the three-dimensional image.

The stone expelling medicine powder as one kind of Chinese medicine for lithiasis of liver and gallbladder system and urinary tract system is suitable for treating cholecystitis, cholelithiasis cholecystolithiasis, bile duct lithiasis, commonbileduct calculous incarceration, renal calculus, ureter lithiasis, etc. It is Chinese patent drug prepared by using the Chinese medicinal herb including Radix Bupleuri, Capillary artemisia, pyrrosia leaf, lysimachia and membrane of chickens gizzard as raw material.

The invention relates to Chinese medicinal decoction used for treating lithiasis and a preparation method thereof, and relates to Chinese medicinal decoction for treating biliary calculus and renal calculus diseases. Main components of the decoction comprise ophiorrhiza pumila, dandelion, rhizoma sparganii, zedoary, white paeony root, herba pyrrosiae, bupleurum, Szechuan lovage rhizome, peach kernel, radix curcumae, gizzard lining, curcuma, knotgrass, gardenia, dried old orange peel, immature tangerine peel, liquorice and the like. The Chinese medicinal decoction can effectively heal intrahepatic bile duct calculus after the gall bladder is extirpated and calcification and sand-like calculus in the kidney, and simultaneously can effectively promote choleresis, improve the self-healing function of the gall bladder, and recover the functions of the gall bladder and the kidney.

The present invention provides a method for inducing directed endoderm stem cells to form intrahepatic bile duct-like cells, the method comprising directing the directed endoderm stem cells to form hepatic endoderm cells, and making the hepatic endoderm cells react with small molecule compounds and Under the directed action of activator of MAPK / PKC signaling pathway, differentiate into human cholangioid cells. The present invention also provides human bile duct-like cells obtained by the method.