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Product and method for identifying hepatocellular carcinoma and intrahepatic cholangiocarcinoma based on MANF as marker

A technology for hepatocellular carcinoma and cell carcinoma, applied in measurement devices, instruments, scientific instruments, etc., can solve the problems of difficult to solve pathological diagnosis, low sensitivity and specificity, and limited application value, so as to reduce the economic burden and improve the Quality of life, effects on improving outcomes

Active Publication Date: 2017-05-10
ANHUI MEDICAL UNIV
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AI Technical Summary

Problems solved by technology

[0003] Existing markers for distinguishing hepatocellular carcinoma from intrahepatic cholangiocarcinoma include AFP / CA199 / Hep Par1 / CK19, etc., but due to their low sensitivity and specificity, their application value in clinical diagnosis and treatment is currently limited, and it is often difficult to resolve pathological changes. Diagnose the problem

Method used

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  • Product and method for identifying hepatocellular carcinoma and intrahepatic cholangiocarcinoma based on MANF as marker
  • Product and method for identifying hepatocellular carcinoma and intrahepatic cholangiocarcinoma based on MANF as marker
  • Product and method for identifying hepatocellular carcinoma and intrahepatic cholangiocarcinoma based on MANF as marker

Examples

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Embodiment 1

[0020] Example 1. Identification of hepatocellular carcinoma patients and intrahepatic cholangiocarcinoma patients in primary liver cancer patients

[0021] like figure 1 As shown, the specific method for distinguishing patients with hepatocellular carcinoma from patients with intrahepatic cholangiocarcinoma among patients with primary liver cancer is as follows:

[0022] Step S1, respectively collect the paraffin specimens of primary liver cancer tumor tissue from 230 cases of primary liver cancer patients with complete clinical and pathological data in a hospital in China in recent years, among which, 150 cases are hepatocellular carcinoma tumor tissue paraffin specimens, and 80 cases are liver cancer tissue specimens. Paraffin specimens of cholangiocarcinoma tumor tissue.

[0023] Among them, the diagnosis of primary liver cancer, hepatocellular carcinoma, and intrahepatic cholangiocarcinoma is based on a comprehensive diagnosis of clinical, histopathological and immunohis...

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Abstract

The invention discloses a product and a method for identifying hepatocellular carcinoma and intrahepatic cholangiocarcinoma based on an MANF as a marker. The invention provides an application of a system for detecting the expression quantity of the MANF in preparation of products for identification or supplementary identification of hepatocellular carcinoma patients and intrahepatic cholangiocarcinoma patients. The hepatocellular carcinoma and the intrahepatic cholangiocarcinoma are identified by taking the MANF as the marker and detecting the expression level of the MANF in a primary hepatocellular carcinoma tissue, a method and an index for effectively identifying the hepatocellular carcinoma and the intrahepatic cholangiocarcinoma are built, the sensitivity is 92.5% and the specificity is 74.7%. A foundation is laid for targeted appropriate treatment and improvement of prognosis of the patients to improve the living quality of the patients and to reduce the economic burden of the patients.

Description

technical field [0001] The invention relates to a product and method for identifying hepatocellular carcinoma and intrahepatic cholangiocarcinoma based on MANF as a marker in the field of biotechnology. Background technique [0002] Liver space-occupying lesions can be benign or malignant tumors, and malignant tumors can be metastatic or primary. Primary carcinoma of the liver is one of the common malignant tumors in my country. The main types of primary liver cancer are hepatocelluler carcinoma (HCC) and intrahepatic cholangiocarcinoma (ICC). At present, the principle of pathological diagnosis of patients with primary liver cancer after surgery is mainly based on histological examination of surgically resected tumor tissue and clinical examination of patients. Because hepatocellular carcinoma and intrahepatic cholangiocarcinoma have similar histological morphology and overlapping immunophenotypes, clinicopathological diagnosis is often difficult; on the other hand, the tr...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N33/574
CPCG01N33/57438
Inventor 沈玉先吴正升李红李庆沈玉君
Owner ANHUI MEDICAL UNIV
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