Application of splenic tyrosine kinase as therapeutic target for intrahepatic cholangiocarcinoma

A technology of therapeutic target and inner bile duct, which is applied in the field of biomedicine, can solve the problems of unknown pathogenesis, ineffective treatment of patients, limited curative effect, etc., and achieve the effect of inhibiting proliferation

Active Publication Date: 2019-03-29
TCM INTEGRATED HOSPITAL OF SOUTHERN MEDICAL UNIV
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Problems solved by technology

However, simple surgery cannot effectively treat most patients (the pathogenesis is unknown, lack of early diagnostic markers, and the chance of surgery has been lost when it is discovered), and the postoperative survival rate is low (5-year survival rate is 8% to 47%). High rate (postoperative intrahepatic recurrence rate of 46% to 68%); non-surgical patients lack effective treatment means, local treatment may benefit a single lesion <3cm, and residual or local recurrence after surgery (overall curative effect Worrying); for unresectable or metastatic advanced cholangiocarcinoma, the chemotherapy regimen of gemcitabine combin

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  • Application of splenic tyrosine kinase as therapeutic target for intrahepatic cholangiocarcinoma
  • Application of splenic tyrosine kinase as therapeutic target for intrahepatic cholangiocarcinoma
  • Application of splenic tyrosine kinase as therapeutic target for intrahepatic cholangiocarcinoma

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Embodiment Construction

[0032] Application of SYK gene or SYK protein as therapeutic target for intrahepatic cholangiocarcinoma.

[0033] Application of SYK antagonist in preparation of medicine for treating intrahepatic cholangiocarcinoma.

[0034] Further, the SYK antagonist is selected from GS-9973, Fostamatinib, R406, and PRT062607.

[0035] Application of SYK expression inhibitor in preparation of medicine for treating intrahepatic cholangiocarcinoma.

[0036] Further, the SYK expression inhibitor is selected from SYK-siRNA, SYK-targeting miRNA or antisense nucleotides and other nucleic acids that down-regulate the expression of SYK.

[0037]Further, intrahepatic cholangiocarcinoma is intrahepatic cholangiocarcinoma in which the expression of SYK is significantly higher than that of normal intrahepatic cholangiocarcinoma. The change in the expression level of SYK can be determined by methods commonly used in the art, such as evaluating the change in expression level by comparing immunohistoche...

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Abstract

The invention discloses an application of splenic tyrosine kinase as a therapeutic target for intrahepatic cholangiocarcinoma. Experiments find out that the expression of SYK in intrahepatic cholangiocarcinoma is increased. In-vitro cell and in-vivo animal experiments find out that the proliferation of intrahepatic cholangiocarcinoma can be effectively inhibited with the use of the SYK antagonistGS-9973, and the inhibiting effect is close to that of a first-line chemotherapeutic drug gemcitabine.

Description

technical field [0001] The invention belongs to the field of biomedicine, and in particular relates to the application of spleen tyrosine kinase as a therapeutic target for intrahepatic cholangiocarcinoma. Background technique [0002] Spleen tyrosine kinase (Spleen tyrosine kinase, SYK) gene was first cloned from pig spleen cDNA in 1991, encoding a non-receptor protein tyrosine kinase. The human SYK gene is located in the q22 region of chromosome 9. The SYK protein contains 635 amino acids. It is a kind of specific protein kinase that can catalyze the phosphorylation of tyrosine residues in substrate proteins, including receptor tyrosine kinases, cytoplasmic Type tyrosine kinases and nuclear tyrosine kinases. Tyrosine protein kinases can regulate signal transduction within and between cells, play an important role in cell differentiation, proliferation and spread, and are closely related to the occurrence and development of tumors. It plays an important role in autoimmune...

Claims

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Application Information

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IPC IPC(8): A61K45/00A61K31/675A61K31/506A61K31/538A61K31/5377A61K31/7105A61P35/00
CPCA61K31/506A61K31/5377A61K31/538A61K31/675A61K31/7105A61K45/00A61P35/00
Inventor 洪健袁辉林泽龙
Owner TCM INTEGRATED HOSPITAL OF SOUTHERN MEDICAL UNIV
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