Application of Nobiletin in Preparation of Drugs for Treating Gastric Receptivity Disorder

A technology of tangerine peel and drug, applied in the field of biomedicine, can solve the problems such as insufficient excavation of medicinal value, anxiolytic effect can not explain the improvement effect of FD symptoms, etc., and achieve the effect of large market prospects and economic value.

Active Publication Date: 2019-07-30
JINGGANGSHAN UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In other words, gastric receptivity is an attractive drug target, which has been proved in clinical trials of FD, and the anxiolytic drugs buspirone and tandospirone have the effect of enhancing gastric receptivity and improving symptoms , its anxiolytic effect does not explain the improvement in FD symptoms
[0005] Southern China is rich in citrus resources, and citrus peel is a medicinal and edible variety. Currently, it is limited to clinical prescriptions and Chinese patent medicines. Its medicinal value has not been fully explored. It should be innovatively developed in accordance with the theory of traditional Chinese medicine, combined with modern medicine and pharmacological technology.

Method used

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  • Application of Nobiletin in Preparation of Drugs for Treating Gastric Receptivity Disorder
  • Application of Nobiletin in Preparation of Drugs for Treating Gastric Receptivity Disorder
  • Application of Nobiletin in Preparation of Drugs for Treating Gastric Receptivity Disorder

Examples

Experimental program
Comparison scheme
Effect test

experiment example 1

[0028] Experimental Example 1 Experiment of Nobiletin's Relaxation Effect on High Potassium Depolarized Gastric Fundus Contraction

[0029] Experimental drugs: Nobiletin, Shanghai Shifeng Biotechnology Co., Ltd., batch number: 14122709; Mosapride tablets, Chengdu Kanghong Pharmaceutical Group Co., Ltd., product batch number: 10030197. Nobiletin has low polarity and is dissolved in absolute ethanol (final concentration is 0.2% v / v). After mosapride is ground, 1% Tween-80 is added for emulsification (final concentration is 0.06% v / v). Refers to the final concentration (mass concentration) in the bath solution.

[0030] Physiological solution: Krebs solution is composed as follows (mM): NaCl 118.4, KCl 4.7, KH 2 PO4 1.2, MgSO4 7H 2 O1.2, CaCl 2 ·H 2 O 2.5, Glucose 11.7, NaHCO 3 26.5.

[0031] Experimental animals: clean grade SD male rats, body weight (300±50) g, provided by Hunan Slack Jingda Experimental Animal Co., Ltd.

[0032] Experimental equipment: RM6240 multi-cha...

Embodiment 2

[0042] Example 2 Effect of Nobiletin on Gastric Empty and Intestinal Propulsion in Mice

[0043] Experimental drugs: Nobiletin, Shanghai Shifeng Biotechnology Co., Ltd., batch number: 14122709; Mosapride tablets, Chengdu Kanghong Pharmaceutical Group Co., Ltd., product batch number: 10030197. Nobiletin and mosapride have low polarity, and they are emulsified with 1% Tween-80 to make intragastric solution.

[0044] Experimental equipment: electronic balance, model: CP214, Ohaus Instruments (Changzhou) Co., Ltd.

[0045] Experimental animals: Kunming mice, male, clean grade, body weight (20±2) g, provided by Hunan Slack Jingda Experimental Animal Co., Ltd. Mice were fed in an environment with a constant temperature of 23±1°C and regular light / dark alternation every 12 hours, with free access to water and food.

[0046] Gastric emptying and intestinal propulsion determination: the mice were randomly divided into 4 groups, 12 in each group, respectively control group (1% Tween-8...

Embodiment 3

[0049] Example 3 Effect of Nobiletin on Delayed Gastric Emptying in Mice Caused by Acute Restraint Stress

[0050] Experimental drugs: Nobiletin, Shanghai Shifeng Biotechnology Co., Ltd., batch number: 14122709; Mosapride tablets, Chengdu Kanghong Pharmaceutical Group Co., Ltd., product batch number: 10030197. Nobiletin and mosapride have low polarity, and they are emulsified with 1% Tween-80 to make intragastric solution.

[0051] Experimental equipment: low-speed centrifuge, Shanghai Anting Scientific Instrument Factory; electronic balance, model: CP214, Ohaus Instruments (Changzhou) Co., Ltd.

[0052] Experimental animals: Kunming mice, male, clean grade, body weight (30±4) g, provided by Hunan Slack Jingda Experimental Animal Co., Ltd. Mice were fed in an environment with a constant temperature of 23±1°C and regular light / dark alternation every 12 hours, with free access to water and food.

[0053] Induction of restraint stress: put the mouse in a 50mL centrifuge tube to...

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Abstract

The invention belongs to the field of biological medicines and particularly relates to an application of nobiletin to preparation of a medicine for treating the gastric receptive disorder. The citrusresource is rich in south China, and the orange peel is a medicinal and edible variety. The medical scientist Tao Jinghong in the southern song dynasty said: 'the dried orange peel has the advantage of treating distension and the older the dried orange peel is, the better the effect is'. But the dried orange peel is only limited to clinic prescriptions and Chinese patent medicines, and the medicinal value is far not taken full use. The application is committed to the modern development of the traditional Chinese medicines, the activity determination technique combining in vitro and in vivo experiments proves for the first time that the nobiletin has a pharmacologic action of selectively loosening the smooth muscle of gastric fundus, the recovery of physiological gastrointestinal motility is promoted, the new treatment medicine is provided for epigastric distention and stomach discomfort caused by the gastric receptive disorder, and the application has a great market prospect and a higheconomical value.

Description

technical field [0001] The invention belongs to the field of biomedicine, and specifically relates to the application of nobiletin in the preparation of drugs for treating gastric receptivity disorder. Background technique [0002] Gastric receptivity refers to the relaxation of the proximal stomach triggered when food reaches the oropharynx, stomach, or duodenum. Receptive relaxation is a unique physiological function of the proximal stomach, which allows the stomach to temporarily accommodate a large amount of food and Regulate your intake. Gastric receptive relaxation disorder can lead to functional dyspepsia (Functional dyspepsia, FD), the main symptoms are abdominal distension and stomach discomfort. In modern society, the incidence of FD is getting higher and higher, which brings a heavy financial burden to the society. [0003] Since the etiology and pathogenesis of the disease are not very clear, in the past it was always believed that delayed gastric emptying was ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/352A61P1/00
CPCA61K31/352
Inventor 李庆耀
Owner JINGGANGSHAN UNIVERSITY
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