Systems and methods for automated analysis

A technology of automatic analysis system and sample analysis system, which is applied in the direction of material analysis, material analysis through optical means, instruments, etc., and can solve problems such as changes in treatment methods and the impact of classification systems

Active Publication Date: 2019-03-15
ABBOTT MOLECULAR INC A CORP ORGANISED & EXISTING UNDER THE LAWS OF THE STATE OF DELAWARE
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Problems solved by technology

As these technological advances are incorporated into routine diagnostic t...

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  • Systems and methods for automated analysis
  • Systems and methods for automated analysis
  • Systems and methods for automated analysis

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Embodiment Construction

[0057]Aspects of the disclosure include sample analysis methods and systems. According to certain embodiments, methods of analyzing a sample in an automated sample analysis system are provided. The method involves introducing a sample and a sample preparation cartridge into the system, isolating and purifying analytes (e.g., nucleic acids and / or proteins) present in the sample at the sample preparation station, and performing analyte detection in an assay mixture comprising the purified analyte Determination. Also provided is an automated sample analysis system that can be used, for example, to perform the methods of the present disclosure. In certain aspects, the methods and systems provide continuous operator access during replenishment or removal of one or any combination of samples, bulk fluids, reagents, items, waste, etc.

[0058] Before the present systems and methods are described in greater detail, it is to be understood that this disclosure is not limited to partic...

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Abstract

Aspects of the present disclosure include sample analysis methods and systems. According to certain embodiments, provided are methods of analyzing samples in an automated sample analysis system. The methods include introducing samples and sample preparation cartridges into the system, isolating and purifying an analyte (e.g., nucleic acids and/or proteins) present in the samples at a sample preparation station, and performing analyte detection assays in assay mixtures that include the purified analyte. Also provided are automated sample analysis systems that find use, e.g., in performing the methods of the present disclosure. In certain aspects, the methods and systems provide for continuous operator access during replenishment or removal of one or any combination of samples, bulk fluids,reagents, commodities, waste, and/or the like.

Description

[0001] Cross References to Related Applications [0002] This application claims the benefit of US Provisional Patent Application 62 / 308,617, filed March 15, 2016, and US Provisional Patent Application 62 / 357,772, filed July 1, 2016, which are hereby incorporated by reference in their entireties. Background technique [0003] Molecular analysis is changing the way healthcare professionals detect and diagnose diseases and conditions. A selection of key technologies, including polymerase chain reaction (PCR) and next-generation sequencing, can help transform the ability to analyze patient samples. As these technological advances are incorporated into routine diagnostic tests, classification systems may be affected and treatment approaches will change. [0004] Real-time PCR analysis improves the way clinical laboratories quantify and diagnose medical conditions and diseases, including cancer, microbial infections, and more. This test method typically combines PCR chemistry wit...

Claims

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Application Information

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IPC IPC(8): G01N35/02
CPCG01N35/00732G01N35/0098G01N35/0099G01N2035/00524G01N2035/0405G01N2035/0436G01N2035/103G01N2035/1048G01N2035/1051G01N21/6428G01N35/026G01N2021/6432G01N2021/6439G01N2035/0401G01N35/04G01N35/10
Inventor J·E·布尔扬特D·P·卡萨萨D·J·哈里斯F·保罗斯克M·泰尔摩尔B·W·约翰逊S·S·娜娜T·J·帕特诺D·M·彼得斯J·P·斯金纳
Owner ABBOTT MOLECULAR INC A CORP ORGANISED & EXISTING UNDER THE LAWS OF THE STATE OF DELAWARE
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