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Application of nicotinamide to preparation of drugs for treating obstructive nephropathy and related renal fibrosis

A technology for obstructive nephropathy and renal fibrosis, applied in drug combination, pharmaceutical formula, urinary system diseases, etc., can solve problems such as loss of renal function and lack of treatment methods, and achieve the effect of reducing renal fibrosis and fibrous changes

Inactive Publication Date: 2019-11-01
THE SECOND XIANGYA HOSPITAL OF CENT SOUTH UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the renal function can only recover 20% after 3 months of complete obstruction of the kidney, and the renal function will be completely lost after 6 months of complete obstruction.
Therefore, there is a lack of effective treatment for long-term renal obstruction

Method used

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  • Application of nicotinamide to preparation of drugs for treating obstructive nephropathy and related renal fibrosis
  • Application of nicotinamide to preparation of drugs for treating obstructive nephropathy and related renal fibrosis
  • Application of nicotinamide to preparation of drugs for treating obstructive nephropathy and related renal fibrosis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] C57BL / 6 mice (male, 8-10 weeks old) underwent unilateral ureteral ligation. Niacinamide 200 / 400 / 800 mg / kg or the same dose of normal saline was injected intraperitoneally 1 hour before the operation for 14 days, and 14 days after the operation. Mice were sacrificed on day 1, and kidney tissues were collected for biochemical and histological analysis. Niacinamide attenuates renal fibrosis induced by unilateral ureteral ligation in vivo figure 1 .

[0028] (A) Masson's trichrome staining of paraffin sections of renal tissues.

[0029] (B) Quantitative analysis of Masson's trichrome staining: Compared with the sham group (sham operation group), the percentage of collagen deposition was significantly increased in UUO (unilateral ureteral ligation) at 14 days. It was shown that UUO caused renal interstitial fibrosis. When UUO 14 days, compared with the normal saline injection group, the injection of different concentrations of nicotinamide significantly reduced the percen...

Embodiment 2

[0039] BUMPT cells were evenly plated in 35mm culture dishes at a density of 0.3×106 cells / dish, and then the cells were starved overnight in serum-free DMEM medium. The cell intervention experiment was carried out according to the concentration of 5ng / ml TGF-β and 25μM nicotinamide. All groups were maintained in serum-free DMEM medium. After 48 hours of treatment, the cell morphology was monitored with a microscope and the cells were collected for biochemical analysis. Niacinamide attenuates transforming growth factor (TGF-β)-induced fibrous changes in proximal tubular cells in mice see figure 2 .

[0040] (A) Representative images of cell morphology under a light microscope. As shown, control BUMPT cells formed a typical cobblestone monolayer with intact intercellular junctions. After TGF-β treatment, the cells were spindle-shaped with reduced intercellular junctions. Addition of NAM together with TGF-β partially prevented the morphological changes. Scale bar: 50 μm.

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Abstract

The invention belongs to the field of drugs and particularly discloses a drug prepared for treating obstructive nephropathy and related renal fibrosis. The drug contains nicotinamide and a pharmacologically acceptable salt of the nicotinamide. The drug can effectively relieve obstructive nephropathy, especially the obstructive renal fibrosis.

Description

technical field [0001] The invention belongs to the field of pharmaceutical application, and in particular relates to a brand-new application of nicotinamide in the preparation and treatment of obstructive nephropathy. Background technique [0002] Obstructive nephropathy is the blockage of the urinary tract, and the upstream flow of urine leads to increased pressure in the kidney, resulting in renal parenchymal damage and renal dysfunction. There are many causes of obstructive nephropathy. For example, obstruction caused by congenital lesions is more common, such as prepuce stenosis and posterior urethral valves; while young adults may cause stenosis due to urinary calculi, infection or traumatic stenosis. The most prominent histopathological feature of obstructive nephropathy is renal interstitial fibrosis, which is the main pathway and pathological basis for the progression of obstructive nephropathy to end-stage renal disease (ESRD). It is characterized by the activatio...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/455A61P13/12
CPCA61K31/455A61P13/12
Inventor 董政郑美玲蔡娟
Owner THE SECOND XIANGYA HOSPITAL OF CENT SOUTH UNIV
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