Method for screening 207 veterinary drugs and additives in animal food

Abstract

The invention discloses a method for screening 207 veterinary drugs and additives in animal food. The method specifically comprises the following steps: preparing a standard working solution; pretreating a to-be-detected sample; establishing a database; detecting a compound; screening the compound; confirming the compound and the like. According to the method, an ultra-high performance liquid chromatography-quadrupole rod/electrostatic field orbitrap high-resolution mass spectrometry technology is utilized to establish a rapid screening and confirmation method for simultaneously detecting 18 types of 207 compounds in animal food within 22 minutes. The method is efficient, the operability is high, good selectivity, precision and sensitivity are realized; convenient and rapid screening can be realized; the false positive rate is low; and the method is especially suitable for screening and confirmation of different kinds of compounds. The invention provides a complete rapid screening andconfirmation detection method for adding various veterinary drugs and additives into animal food, a detection and screening technical means for multiple residues in animal food is added; and the safety guarantee is provided for the national animal husbandry industry and food safety.

Description

technical field [0001] The invention belongs to the technical field of animal food detection, and in particular relates to a method for screening and confirming 207 kinds of veterinary drugs and additives in animal food. Background technique [0002] Veterinary drugs refer to substances used to prevent, treat, and diagnose animal diseases or purposefully regulate animal physiological functions, and can generally be divided into antibiotics, anthelmintics, growth promoters, antiprotozoal drugs, trypanosomiasis, and sedatives and β-adrenoceptor blocker veterinary drugs. [0003] In recent years, my country's animal husbandry has developed rapidly, which is inseparable from the development and rational use of veterinary drugs. Veterinary medicine plays an important role in reducing the morbidity and mortality of livestock and poultry, promoting animal growth, improving animal product quality and improving feed utilization. However, the abuse of veterinary drugs is relatively ...

AI Technical Summary

Problems solved by technology

[0006] At present, the existing multi-residue detection methods in my country mainly include liquid chromatography-tandem quadrupole and liquid chromatography-high resolution mass spectrometry detection methods, among which the traditional liquid chromatography-tandem quadrupole has the characteristics of high sensitivity and accurate quantification. However, there are disadvantages such as low resolution, easy to cause false positives, limited number of detection drugs, and complicated establishment of instrument methods.

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