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Digital biomarkers for muscular disabilities

A muscular dystrophy, data technology, applied in the field of disease tracking

Pending Publication Date: 2020-08-04
F HOFFMANN LA ROCHE & CO AG
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, these genetic testing methods are only suitable in cases where the underlying development of SMA is already suspected, for example because of a parent's medical history

Method used

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  • Digital biomarkers for muscular disabilities
  • Digital biomarkers for muscular disabilities
  • Digital biomarkers for muscular disabilities

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0189] Embodiment 1: A method of evaluating spinal muscular atrophy (SMA) in a subject, comprising the following steps:

[0190] a) using a mobile device to determine at least one performance parameter from a data set of pressure measurements of individual finger forces from said subject; and

[0191] b) evaluating the SMA by comparing the determined at least one performance parameter with a reference.

Embodiment 2

[0192] Embodiment 2: The method of embodiment 1, wherein the SMA is SMA1 (Werdnig-Hoffmann's disease), SMA2 (Dubowitz's disease), SMA3 (Kugelberg-Welander's disease) or SMA4.

Embodiment 3

[0193] Embodiment 3: The method of embodiment 1 or 2, wherein said at least one performance parameter is a parameter indicative of muscle hypotonia in a respective finger.

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PUM

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Abstract

The present invention relates to the field of disease tracking and potentially even diagnostics. Specifically, it relates to a method of assessing a muscular disability and, preferably, spinal muscular atrophy (SMA) in a subject comprising the steps of determining at least one performance parameter from a dataset of pressure measurements of the individual finger strength from said subject using amobile device, and comparing the determined at least one performance parameter to a reference, whereby the muscular disability and, preferably, SMA will be assessed. The present invention also relatesto a mobile device comprising a processor, at least one pressure sensor and a database as well as software which is tangibly embedded to said device and, when running on said device, carries out themethod of the invention as well as the use of such a device for assessing a muscular disability and, preferably, SMA.

Description

technical field [0001] The invention relates to the field of disease tracking, and potentially even supports diagnostic processing. In particular, the present invention relates to a method of assessing muscular disability, and preferably spinal muscular atrophy (SMA), in a subject, the method comprising the steps of: At least one performance parameter is determined in the pressure measurement data set for each finger strength, and the determined at least one performance parameter is compared with a reference, thereby assessing muscle disability, and preferably SMA. The invention also relates to a mobile device comprising a processor, at least one pressure sensor and a database, and software tangibly embedded in said device and which, when run on said device, performs the method of the invention And use of such devices to assess muscular disability, and preferably SMA. Background technique [0002] Spinal muscular atrophy (SMA) is an autosomal recessive disorder also known ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G16H50/20A61B5/00
CPCA61B5/6898A61B5/7264A61B5/225A61B5/4082A61B5/7275G16H50/20G16H40/67G16H70/60G16H50/50G16H50/30A61B5/1101A61B5/1124A61B5/681A61B5/7282A61B5/7435A61B5/7475A61B2562/0247G01L1/142G06F3/0414
Inventor C.戈森斯M.林德曼
Owner F HOFFMANN LA ROCHE & CO AG
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