A kind of pharmaceutical composition for treating polycystic ovary syndrome and its application

A technology for polycystic ovary and syndrome, applied in drug combinations, medical preparations containing active ingredients, pharmaceutical formulas, etc., can solve the problem of high risk ratio

Active Publication Date: 2021-03-09
HEILONGJIANG UNIV OF CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the pathogenesis of PCOS is not completely clear. Insulin resistance and hyperinsulinemia are common metabolic abnormalities in patients with polycystic ovary syndrome, and there are obvious metabolic sequelae. Endometrial cancer, cardiovascular disease, dyslipidemia and II proportionately higher risk of type 2 diabetes

Method used

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  • A kind of pharmaceutical composition for treating polycystic ovary syndrome and its application
  • A kind of pharmaceutical composition for treating polycystic ovary syndrome and its application
  • A kind of pharmaceutical composition for treating polycystic ovary syndrome and its application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] Example 1: Effect of Fast Green on PCOS Rat Model

[0018] 1. Grouping and administration of experimental animals

[0019] Thirty 6-week-old SD clean-grade female rats with regular estrous cycle were randomly divided into groups. Each vaginal smear was used to observe the changes of the estrous cycle. Letrozole was dissolved in normal saline to a concentration of 1%, and 3 g of fast green (FGF) was dissolved in 50 ml of normal saline to a concentration of 60 mg / ml. in,

[0020] Group A (10 rats): blank control group, free to eat and drink;

[0021] Group B (10 rats): PCOS model group, daily intragastric administration of letrozole 1mg / kg, 21 days later, intragastric administration of 5ml / kg normal saline for 10 days;

[0022] Group C (10 rats): fast green group, daily intragastric administration of letrozole 1mg / kg, 21 days later, 5ml / kg fast green solution with a concentration of 6% orally for 10 days.

[0023] The body weight of the rats was detected daily, and t...

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PUM

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Abstract

The invention discloses the application of Fast green FCF (FGF) in the preparation of medicines for treating polycystic ovary syndrome (PCOS). The invention also discloses a pharmaceutical composition for treating polycystic ovary syndrome (PCOS), which comprises Fast green FCF (FGF) and pharmaceutically acceptable excipients. The results of pharmacodynamic experiments show that Fast Green has a good ovulation-stimulating effect, can restore the normal shape of the ovary, and reduce the level of local inflammatory factors in the ovary, which can effectively treat polycystic ovary syndrome.

Description

technical field [0001] The invention relates to the technical field of medicines, in particular to a pharmaceutical composition for treating polycystic ovary syndrome and its application. Background technique [0002] Polycystic ovary syndrome (PCOS) is a common and refractory disease among gynecological endocrine diseases, and it is more likely to occur in adolescents and women of childbearing age. Clinically, persistent anovulation or oligoovulation, hirsutism, acne, obesity, oligomenorrhea and even amenorrhea are common, which have seriously affected women's physical and mental health and quality of life. At present, the pathogenesis of PCOS is not completely clear. Insulin resistance and hyperinsulinemia are common metabolic abnormalities in patients with polycystic ovary syndrome, and there are obvious metabolic sequelae. Endometrial cancer, cardiovascular disease, dyslipidemia and II higher risk of type 2 diabetes. [0003] In the existing treatment methods for PCOS,...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/185A61K45/06A61P15/08
CPCA61K31/185A61K45/06A61P15/08
Inventor 朱小琳韩亚光韩延华韩亚鹏
Owner HEILONGJIANG UNIV OF CHINESE MEDICINE
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