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Application of isosteviol (ISV) in preparation of medicine for treating sepsis

A technology of isosteviol and sepsis, which is applied in the field of application of isosteviol in the preparation of drugs for treating sepsis, can solve the problems that there are no research reports on the treatment of sepsis, and achieve the goal of improving the survival rate and inhibiting the increase in High, improve the effect of related symptoms

Pending Publication Date: 2021-02-05
NANJING UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Existing studies have shown that isosteviol has antihypertensive and hypoglycemic effects, but there is no research report on the treatment of isosteviol for sepsis

Method used

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  • Application of isosteviol (ISV) in preparation of medicine for treating sepsis
  • Application of isosteviol (ISV) in preparation of medicine for treating sepsis
  • Application of isosteviol (ISV) in preparation of medicine for treating sepsis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] Example 1. Intraperitoneal injection of LPS caused sepsis in mice, and intragastric administration of isosteviol was performed while the model was being established.

[0019] C57BL / 6 mice, female, 6-8 weeks old. 10 in each group. Grouping situation: solvent control group (0.5% CMC-Na solution), sepsis group (intraperitoneal injection of 10 mg / kg LPS), low-dose isosteviol group (LPS + isosteviol 20 mg / kg) and high-dose isosteviol group (LPS+ isosteviol 40mg / kg).

Embodiment 2

[0020] Example 2. Isosteviol improves the survival rate of septic mice.

[0021] Continue to observe the survival of the mice in each group in Example 1 above, record the number of surviving mice in each group every 2 hours, and keep observing and recording until 48 hours after modeling. Draw the survival rate curve, the results are shown in the appendix figure 1 .

Embodiment 3

[0022] Example 3. Isosteviol inhibits inflammatory factors in serum of septic mice.

[0023] Intraperitoneal injection of LPS caused sepsis in mice, and intragastric administration of isosteviol was performed at the same time as model establishment. C57BL / 6 mice, female, 6-8 weeks old. 10 in each group. Grouping situation: solvent control group (0.5% CMC-Na solution), sepsis group (intraperitoneal injection of 10 mg / kg LPS), low-dose isosteviol group (LPS + isosteviol 20 mg / kg) and high-dose isosteviol group (LPS+ isosteviol 40mg / kg). Blood was collected 12 hours after modeling, the serum was separated, and the protein expression of IL-6, TNFα and IL-1β in the serum was detected by ELISA kit. Statistics for each group of data, the results are shown in the appendix figure 2 (A, B, C).

[0024] The results show:

[0025] 1. Intraperitoneal injection of LPS caused sepsis in mice, and different doses of isosteviol were administered intragastrically at the same time, and the...

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Abstract

The invention discloses application of isosteviol (ISV) serving as an active ingredient to treatment of sepsis. Compared with the prior art, the ISV has the characteristics of high efficiency and lowtoxicity. The ISV can significantly improve the survival rate of sepsis mice, inhibit the expression of inflammatory factors IL-6, TNF[alpha] and IL-1[beta] in the bodies of the sepsis mice, and improve the damage of the sepsis to the bodies. The effects show that the ISV can be used for treating the sepsis and has medicine development prospects.

Description

technical field [0001] The invention discloses the application of isosteviol in the preparation of medicines for treating sepsis, and belongs to the technical field of new uses of isosteviol. Background technique [0002] The incidence of sepsis is high, with more than 18 million cases of severe sepsis worldwide each year. Sepsis is a dangerous condition with a high fatality rate. About 14,000 people worldwide die from its complications every day. According to foreign epidemiological surveys, the fatality rate of sepsis has surpassed that of myocardial infarction, and it has become the main cause of death of non-cardiac patients in the intensive care unit. In recent years, although anti-infection therapy and organ function support technology have made great progress, the fatality rate of sepsis is still as high as 30% to 70%. The cost of sepsis treatment is high, and the consumption of medical resources is large, which seriously affects the quality of life of human beings ...

Claims

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Application Information

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IPC IPC(8): A61K31/19A61P31/04
CPCA61K31/19A61P31/04
Inventor 吴旭东张宇轩黄伟
Owner NANJING UNIV
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