Application of a kind of tmub1 protein in preparation of molecular detection agent for tumor immunosuppression

Abstract

The invention discloses the application of a TMUB1 protein in the preparation of a tumor immunosuppressive molecule detection agent, and provides a method for detecting the expression level of the TMUB1 protein and the application of a TMUB1 protein inhibitor to inhibit the tumor immunosuppressive molecule. In the present invention, low The expression level of TMUB1 can significantly reduce the protein level of PD-L1, block the accumulation of PD-L1 protein in tumor cells from the source of PD-L1 protein synthesis, and prevent immune escape of tumor cells.

Description

Application of a TMUB1 protein in the preparation of tumor immunosuppressive molecular detection agent (1) Technical field [0001] The present invention relates to the application of a TMUB1 protein in the preparation of a tumor immunosuppressive molecular detection agent. (2) Background technology [0002] According to the latest World Cancer Report 2020 by the World Health Organization (WHO) in February, in the next two decades , the number of cancer cases worldwide could increase by 60%. In low- and middle-income countries, the increase could be as high as 81%. Global per One in six people die of cancer every year, and the cancer burden (Cancer Burden) is increasing. In 2018, there were approximately 9.6 million People die from cancer. The global experience of "preventing cancer and treating cancer" shows that ‑ implementing comprehensive strategies such as tobacco control, vaccination, regular cancer Disease screening, as well as effective diagnosis and treatmen...

AI Technical Summary

Problems solved by technology

Therefore, the high expression level of TMUB1 in tumor tissue can predict the high level of PD-L1, which indicates the poor effect of immunotherapy in tumor tissue and the poor prognosis of tumor treatment.

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