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Medicine for preventing and treating damage of chemical toxic preparations and heavy metals to cells

A technology of heavy metals and medicines, applied in the direction of anti-toxic agents, drug delivery, drug combination, etc., can solve the problems of manufacturing, storage and application restrictions, preparation, storage and administration restrictions, easy oxidation, etc., to reduce costs and facilitate promotion application, damage reduction effect

Pending Publication Date: 2021-06-15
上海保亿仁生物医药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

This technology helps protect against harmful substances such as chemically reactive agents or radioisotopes during their production, transporting them safely for use on humans without causing any health concerns. It also reduces costs compared with traditional methods like adding these materials into pharmaceutical formulations. Overall, this technology improves safety measures for administered medicines and other compounds containing nitrogen atoms.

Problems solved by technology

This patents discusses how chemotherapy drugs or other substances harmful for humans may affect their ability to fight against cancer called sarcotoxins. These compounds include pesticides like mepyridostat mesothione A, dichlofenamide, trichlorfonil, bifazimuthalate, carbarytena nicotianum, pyrethrines, nitrogen dioxide, sulfur hexavalasulfuricans, polynaphyrims, naphthaquinones, tetrafluorobutane, pertechnetricyanese salt, selenium, chromite, cathode ray tubes, radionucleators, lithography reservoirs containing them, and various methods have attempted to solve this issue.

Method used

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  • Medicine for preventing and treating damage of chemical toxic preparations and heavy metals to cells

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] A medicine for preventing and preventing cells from being damaged by chemical toxic agents and heavy metals. The medicine contains NMN, and the medicine contains NMN and physiological saline, and the concentration of the NMN in the normal saline is 400 μg / mL.

experiment example 1

[0024] In this example, potassium cyanide was used to establish a hepatic hypoxic injury model, and the changes in the expression of Bcl-2, Bax, Bcl-XL and other proteins were observed after the hepatocytes were subjected to hypoxic injury caused by potassium cyanide, so as to verify that NMN For the prevention and treatment of cells suffering from hypoxic damage.

[0025] A. Materials and methods

[0026] 1.1L02 cell culture and main reagents:

[0027] The normal human liver cell line L02 was purchased from the Shanghai Institute of Cells, Chinese Academy of Medical Sciences, and was fully cultured in RPMI 1640 containing 10% fetal bovine serum based on a 37°C, 5% CO2 incubator. Mouse anti-human Bcl-2, Bax and Bcl-XL monoclonal antibodies, FITC-labeled secondary antibodies were purchased from Beijing Zhongshan Company. Potassium cyanide, analytically pure, provided by the Reagent Center of our hospital.

[0028] 1.2 MTT method detection of different potassium cyanide conce...

experiment example 2

[0045] Using the method of Experimental Example 1, potassium cyanide was replaced by metal mercury ion solution, and the test showed that the drug NMN of Example 1 of the present invention can enhance the expression of Bcl-2 and Bcl-XL and reduce the expression of Bax, indicating that NMN inhibits the expression of mercury caused by metal mercury. apoptosis of hepatocytes.

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Abstract

The invention discloses a medicine for preventing and treating damage of chemical toxic preparations and heavy metals to cells. The medicine contains NMN. The medicine has the advantages of being low in cost, convenient to store, stable in property, capable of effectively preventing and treating cell hypoxic damage and the like.

Description

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Claims

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Application Information

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Owner 上海保亿仁生物医药有限公司
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