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The use of an mglur5 antagonist for treating opioid analgesic tolerance

An antagonist, opioid technology, applied in the field of mGluR5 antagonists

Pending Publication Date: 2021-08-24
NOVARTIS AG
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Morphine tolerance has been treated eg with ibudilast, minocycline, fluorocitrate, propentofylline, however, use of these drugs is associated with significant adverse events

Method used

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  • The use of an mglur5 antagonist for treating opioid analgesic tolerance
  • The use of an mglur5 antagonist for treating opioid analgesic tolerance
  • The use of an mglur5 antagonist for treating opioid analgesic tolerance

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1a

[0027]Example 1a: An mGluR5 antagonist for use in the treatment of opioid analgesic tolerance associated with chronic opioid use in chronic pain.

Embodiment 2a

[0028] Example 2a: An mGluR5 antagonist for use in the treatment of opioid analgesic tolerance associated with chronic opioid use in chronic pain, the treatment reversing the opioid analgesic tolerance.

Embodiment 3a

[0029] Example 3a: An mGluR5 antagonist for use in reversing opioid analgesic tolerance associated with chronic opioid use in chronic pain.

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PUM

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Abstract

The invention relates to the use of a mGluR5 antagonist for the treatment of opioid analgesic tolerance associated with chronic opioid use in chronic pain.

Description

technical field [0001] The present invention relates to the use of mGluR5 antagonists for the treatment of opioid analgesic tolerance associated with chronic opioid use in chronic pain. Background technique [0002] Pain management is a major healthcare challenge that requires a careful balance between pain control and associated adverse events. In Europe, one in five people suffers from chronic pain. Furthermore, pain-associated disorders are on the rise, and furthermore, only one-third to two-thirds of the chronic pain patient population report >50% pain relief (Trends in Neurosciences, 2014, Vol. 37, Issue 3, 146). [0003] Opioids such as morphine are powerful analgesics used to treat moderate to severe chronic pain of non-malignant or malignant (ie cancer) origin. However, while medical guidelines recommend the use of opioid therapy for the management of cancer pain, its use in the long-term management of nonmalignant pain is problematic, especially due to the man...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/404A61K31/4439A61K31/485A61K31/135A61K31/137A61K31/215A61K31/4468A61K31/451A61K31/4535A61P25/04
CPCA61K31/4439A61K31/485A61K31/215A61K31/135A61K31/4468A61K31/4535A61K31/451A61K31/137A61P25/04A61K31/404A61K31/551A61K31/44A61K45/06A61K2300/00
Inventor R·C·E·多尔梅奇F·加斯帕里尼B·戈麦斯-曼西拉
Owner NOVARTIS AG
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