Traditional Chinese medicine composition for treating primary dysmenorrhea and preparation method thereof

Abstract

The medicinal composition for treating primary dysmenorrhea and the preparation method thereof have the following weight proportions: 50-150 parts of angelica, 30-90 parts of cinnamon, 30-90 parts of woody fragrance, and 75-225 parts of vinegar-made corydalis. Angelica sinensis uses volatile oil, the polysaccharide extract of Angelica sinensis obtained by alcohol precipitation of the water decoction of medicinal dregs after extracting the volatile oil, and elutes the macroporous adsorption resin column on the alcohol precipitation liquid with ethanol to obtain the angelica phenolic acid extract; , and the alcohol-precipitated liquid of the water decoction of the dregs after extracting the volatile oil, recovering ethanol, concentrating, and making a clear paste; Corydalis is extracted with ethanol reflux, and the Corydalis alkaloid extract obtained by eluting with ethanol on a macroporous adsorption resin column ; The active components of the medicine of the present invention are obtained after each extract is mixed. The invention maintains the analgesic effect of the prior art, reduces adverse reactions of dysmenorrhea, and has better antispasmodic effect at the same time. The preparation method is reasonable in technology and can be produced in large scale.

Description

technical field [0001] The invention relates to the technical field of traditional Chinese medicines, in particular to a traditional Chinese medicine composition for treating primary dysmenorrhea and a preparation method thereof. Background technique [0002] Dysmenorrhea refers to obvious lower abdominal pain during menstruation or before and after menstruation, manifested as distending pain or spasmodic pain, or accompanied by backache and distending pain, general discomfort, which affects life, work or study. Dysmenorrhea is divided into primary dysmenorrhea and secondary dysmenorrhea according to the incidence of dysmenorrhea. Primary dysmenorrhea refers to dysmenorrhea caused by no obvious organic lesions in the reproductive organs, mostly functional dysmenorrhea, and mainly occurs in adolescent girls and unmarried or childless young women. [0003] Western medicine mostly uses antispasmodic, sedative and analgesic therapy, oral contraceptives, prostate synthase inhibi...

AI Technical Summary

Problems solved by technology

[0006] Since the original prescription of Tongjingbao Granules is composed of nine traditional Chinese medicines, there are many types of medicines used, and the dosage of the preparations is relatively large. It is relatively difficult to control the quality during the production process. In clinical use, due to its strong effect of promoting blood circulation and removing blood stasis, After taking it, patients often have adverse reactions that reflect a significant increase in menstrual flow

[0007] After searching, there are some traditional Chinese medicine compositions for treating primary dysmenorrhea in the existing patents such as "Tongjingsan Granule" (patent No. 93111705.4), "a kind of oral Chinese medicine for treating primary dysmenorrhea" (application No. 200610130819.5), "a A traditional Chinese medicine composition for the treatment of dysmenorrhea" (application number 200810139921.0), etc., but there are many types of medicines that make up these prescriptions, and they are mostly taken as decoctions, or the process is relatively simple. After extracting the extract, they are directly made into oral preparations, although It has a certain effect, but the extraction rate of active ingredients is not high, and the preparation is relatively thick, which is not conducive to controlling its production quality

[0008] Although some compositions have a simple medicinal taste, such as "medicine for treating women's dysmenorrhea and its preparation method" (Patent No. 200510025931.8) uses angelica, corydalis, and cinnamon, but only uses angelica volatile oil, cinnamon volatile oil and corydalis alkaloids, The water extract of Angelica sinensis and the water extract of cinnamon have not been fully utilized, and many literatures have reported that the water extract of Angelica sinensis contains phenolic acids and polysaccharides and other active ingredients for treating dysmenorrhea. The phenolic acids have antithrombotic and platelet aggregation effects, and polysaccharides It has blood-enriching, blood-activating and analgesic effects (Wang Fang, Li Dong. Advances in chemical and pharmacological research of Angelica sinensis [J]. Chinese Pharmacy, 2003, 14(10): 630-631. Le Jiang, Peng Renxiu, Kong Rui, etc. Angelica sinensis Experimental study on the analgesic effect of crude polysaccharides [J]. Chinese Journal of Pharmaceutical Sciences, 2002, 37(10): 746-748); cinnamon water extract also has analgesic and anti-inflammatory effects (Zhu Ziping, Zhang Mingfa, Shen Zhiqin, etc. Cinnamon Pharmacological research on warming and relieving pain[J]. Chinese Journal of Traditional Chinese Medicine, 1993, 18(9): 553-556. Fang Qin. Research progress of cinnamon [J]. New Chinese Medicine and Clinical Pharmacology, 2007, 18(3): 249 -252.)

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