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A novel micropeptide screened based on pan-cancer expression profile and its application

An expression profiling and micropeptide technology, applied in the field of biomedicine, can solve problems such as difficult to explain dual functions of tumors, lack of sensitivity of glutathione gene sets, etc.

Active Publication Date: 2022-02-18
THE FIRST AFFILIATED HOSPITAL OF WANNAN MEDICAL COLLEGE YIJISHAN HOSPITAL OF WANNAN MEDICAL COLLEGE
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Problems solved by technology

Although the glutathione family has been extensively studied in cancer, it has been difficult to explain its dual function in tumors
Existing studies lack systematic studies of the glutathione gene set in pan-cancer and the sensitivity of the glutathione gene set as a potential biomarker for treatment

Method used

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  • A novel micropeptide screened based on pan-cancer expression profile and its application
  • A novel micropeptide screened based on pan-cancer expression profile and its application
  • A novel micropeptide screened based on pan-cancer expression profile and its application

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Embodiment Construction

[0042] The technical solutions of the present invention will be described in detail below with reference to the accompanying drawings, but the protection scope of the present invention is not limited to the embodiments.

[0043] A novel micropeptide screened out based on pan-cancer expression profiles, the micropeptide is AC078846-aa encoded by lncRNA AC078846.

[0044] Application of a micropeptide AC078846-aa screened based on pan-cancer expression profiles in drugs for inhibiting liver cancer.

[0045]A screening method for micropeptide AC078846-aa, comprising the following screening steps:

[0046] S1. Screening of glutathione gene sets using a bioinformatics database;

[0047] S2. Based on the significant differential expression and survival analysis of the glutathione gene sets screened in S1 in pan-cancer, GLS with significantly high expression and high risk of poor prognosis in liver cancer was screened out;

[0048] S3, GLS verification and ceRNA prediction in liver...

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Abstract

The invention discloses a novel micropeptide screened out based on a pan-cancer expression profile, a screening method and its application in drugs for inhibiting liver cancer. A screening method for the micropeptide AC078846‑aa, comprising the following screening steps: S1, screening of the glutathione gene set using a bioinformatics database; S2, screening of the glutathione gene set screened in S1 in pan-cancer Significant differential expression and survival analysis, screening out GLS that is both significantly high expression and high risk of poor prognosis in liver cancer; S3, verification of GLS in liver cancer and ceRNA prediction, screening and verification of lncRNA AC078846, verification of LIHC and normal in multiple databases Significant differential expression in tissue comparison; S4, identification and functional analysis of micropeptide AC078846‑aa encoded by lncRNA AC078846. The invention provides a new target for the treatment of liver cancer.

Description

technical field [0001] The invention relates to the technical field of biomedicine, in particular to a novel micropeptide screened out based on a pan-cancer expression profile, a screening method and its application in drugs for inhibiting liver cancer. Background technique [0002] Scientific advancement in cancer research is patient-centered [Salamone JM, Lucas W, Brundage SB, Holloway JN, Stahl SM, Carbine NE, London M, Greenwood N, Goyes R, Chisholm DC. Promoting Scientist–Advocate Collaborations in Cancer Research : Why and How. Cancer research 2018,78(20):5723-5728.]. Over the past decade, there has been an increasing trend in genome-wide pan-cancer analysis. More and more scientists are working on the mechanism of cancer, hoping to prolong the survival of cancer patients by updating diagnosis and treatment methods. [0003] Pan-cancer research is increasingly recognized as a serious public health problem worldwide. Cancer is driven by genetic changes that have been...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07K14/00A61K38/16A61P35/00G16B40/00G16B50/30
CPCC07K14/00A61P35/00G16B40/00G16B50/30A61K38/00
Inventor 蒋澜杨建课吕坤童九翠钟民
Owner THE FIRST AFFILIATED HOSPITAL OF WANNAN MEDICAL COLLEGE YIJISHAN HOSPITAL OF WANNAN MEDICAL COLLEGE
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