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Application of dimethyl itaconate in preparation of medicine for treating and/or preventing neurodegenerative diseases

A dimethyl itaconic acid, neurodegenerative technology, which is applied in the field of degenerative disease treatment drugs to achieve the effects of improving cognitive impairment, improving synaptic ultrastructural damage, and reducing neuroinflammation

Pending Publication Date: 2021-11-19
XUZHOU MEDICAL UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, whether dimethyl itaconate can improve cognitive impairment and neurodegenerative diseases caused by obesity has not been reported.

Method used

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  • Application of dimethyl itaconate in preparation of medicine for treating and/or preventing neurodegenerative diseases
  • Application of dimethyl itaconate in preparation of medicine for treating and/or preventing neurodegenerative diseases
  • Application of dimethyl itaconate in preparation of medicine for treating and/or preventing neurodegenerative diseases

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Embodiment Construction

[0047] The present invention is further described below by examples, but the present invention is not limited by these examples. Any modification, equivalent replacement, improvement, etc. made within the spirit and principle of the present invention shall be included within the protection scope of the present invention.

[0048] The invention provides the application of dimethyl itaconate in the preparation of medicines for treating and / or preventing neurodegenerative diseases. In vitro experiments confirmed that dimethyl itaconate can effectively inhibit neuroinflammation mediated by microglia.

[0049] The inventors found in the research that dimethyl itaconate can significantly improve the cognitive impairment induced by obesity. In vivo experiments have verified that dimethyl itaconate can improve learning, memory, and self-care ability decline, improve synaptic ultrastructure, inhibit microglial activation, and down-regulate neuroinflammation.

[0050] The above-mentio...

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Abstract

The invention belongs to the technical field of drugs for treating degenerative diseases, and relates to application of dimethyl itaconate in preparation of a medicine for treating and / or preventing neurodegenerative diseases. Experiments prove that the dimethyl itaconate can alleviate the decline of learning and memory ability and the damage of synaptic ultrastructures, and reduce neuroinflammation.

Description

technical field [0001] The invention belongs to the technical field of drugs for treating degenerative diseases, and relates to the application of dimethyl itaconate in the preparation of drugs for treating and / or preventing neurodegenerative diseases. Background technique [0002] Alzheimer's disease (AD), the main type of senile dementia, is a major medical problem faced by the world. According to a report released by the International Alzheimer's Association in 2018, there is one case of AD every 3 seconds in the world. Global AD-related economic costs are estimated to be $2 trillion by 2030. So far, there is still a lack of effective drugs and therapies for the treatment of AD. Since the pathogenesis of the disease is not yet fully understood, most patients are already in the advanced stage of the disease when they are clinically diagnosed, so it is difficult to reverse the neuropathy in the brain by drugs. [0003] Obesity is an epidemic and systemic metabolic diseas...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/225A61P25/28A61P3/04
Inventor 潘伟于英华赵进秀何妍颜子易徐大祥杨晓莹张鹏胡敏敏胡涛李梦迪
Owner XUZHOU MEDICAL UNIV
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