Application of dimethyl itaconate in preparation of medicine for treating and/or preventing neurodegenerative diseases
A dimethyl itaconic acid, neurodegenerative technology, which is applied in the field of degenerative disease treatment drugs to achieve the effects of improving cognitive impairment, improving synaptic ultrastructural damage, and reducing neuroinflammation
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[0047] The present invention is further described below by examples, but the present invention is not limited by these examples. Any modification, equivalent replacement, improvement, etc. made within the spirit and principle of the present invention shall be included within the protection scope of the present invention.
[0048] The invention provides the application of dimethyl itaconate in the preparation of medicines for treating and / or preventing neurodegenerative diseases. In vitro experiments confirmed that dimethyl itaconate can effectively inhibit neuroinflammation mediated by microglia.
[0049] The inventors found in the research that dimethyl itaconate can significantly improve the cognitive impairment induced by obesity. In vivo experiments have verified that dimethyl itaconate can improve learning, memory, and self-care ability decline, improve synaptic ultrastructure, inhibit microglial activation, and down-regulate neuroinflammation.
[0050] The above-mentio...
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