9 results about "Dimethylitaconate" patented technology

The application provides application of dimethyl itaconate in prevention and treatment of chronic stress-induced anxiety. The application finds that dimethyl itaconate can inhibit excessive activation of microglial cells in a stress state, improve mitochondrial structure and function abnormalities of the microglial cells, and reduce expression of a lysosome marker CD68, so as to inhibit central nervous inflammation, maintain central nervous immune homeostasis, prevent and relieve anxiety-like behavior induced by chronic stress, and effectively prevent and relieve occurrence and development of chronic stress-induced anxiety (generalized anxiety disorder).

The invention discloses a biodegradable drag reducer for fracturing as well as a preparation method and application thereof, and the drag reducer is prepared from the following raw materials in parts by weight: 8 to 12 parts of acrylamide, 5 to 8 parts of 2-acrylamido-2-methylpropanesulfonic acid, 2 to 4 parts of dimethyl itaconate, 1.5 to 3 parts of methacrylic acid-beta-cyclodextrin, 0.1 to 0.3 part of cross-linking agent and 0.04 to 0.08 part of initiator. And 70 to 90 parts of deionized water. The drag reducer can be quickly degraded into small molecules in a specific environment, so that the problem of permanent damage of a synthetic drag reducer to a reservoir is fundamentally solved, and the damage rate of a rock core is reduced compared with that of a traditional product; and the drag reduction agent also has excellent self-repairing capability, and after high-speed shearing, the retention rate of the drag reduction rate can still reach 80% or above, so that the long-term stability and effectiveness of the fracturing process are ensured.

This application discloses the use of itaconic acid derivatives in the preparation of drugs for treating candidemia, belonging to the field of biomedical technology. The itaconic acid derivatives proposed in this application are dimethyl itaconic acid and / or 4-octyl itaconic acid. Dimethyl itaconic acid exhibits a dose-dependent therapeutic effect in model mice, with an optimal dose of 1200 mg / kg improving survival rate and reducing kidney damage; 4-octyl itaconic acid can enhance the anti-Candida albicans ability of macrophages and regulate the expression of inflammatory factors. The application of the itaconic acid derivatives proposed in this application in the treatment of candidemia works through immunomodulation, circumventing fungal resistance. Furthermore, the drugs are low in toxicity, have good biocompatibility, and use a universal experimental system, providing a new approach for the clinical treatment of candidemia with broad application prospects. This application also protects pharmaceutical compositions for treating candidemia with dimethyl itaconic acid and / or 4-octyl itaconic acid as active ingredients.

The invention provides a chitosan-dimethyl itaconate conjugate and a synthetic method thereof. The synthetic method comprises the following steps: dissolving CS in deionized water; dissolving DMI in absolute ethyl alcohol; then gradually dropwise adding the dimethyl itaconate solution into the chitosan solution, adding a proper amount of absolute ethyl alcohol, and fully dissolving reactants to form a uniform solution; adding sodium hydroxide to adjust pH; primary amine groups on a CS chain are used as nucleophilic reagents to attack ester carbonyl carbon atoms of DMI, nucleophilic substitution reaction is carried out, and finally amido bonds are formed. Heating reactants under a dark condition, slowly stirring to complete reaction, and ventilating and drying in a drying oven to form a thin film; and eluting the thin film with absolute ethyl alcohol to obtain a final product CS-DMI. The chitosan-dimethyl itaconate synthesized by the method disclosed by the invention has good biocompatibility and anti-inflammatory and antibacterial properties. A strategy and reference are provided for coupling the small molecule medicine to the chitosan, developing a water-soluble high polymer material and applying the small molecule medicine to a medical material.

The invention discloses a solid thickening agent for fracturing and a preparation method thereof, and relates to the technical field of chemical treatment agents. The water-based adhesive is prepared from the following components in parts by weight: 30 to 35 parts of N-hydroxyethyl acrylamide, 18 to 24 parts of N-(3-methoxypropyl) acrylamide, 14 to 16 parts of vinyl sulfonate, 8 to 10 parts of vinyl benzoate, 6 to 8 parts of diacetone acrylamide, 4 to 6 parts of dimethyl itaconate, 2 to 4 parts of dodecyl benzene sulfonic acid isopropylamine salt, 120 to 140 parts of deionized water and 1 to 2 parts of azodiisobutylimidazoline hydrochloride. The materials are put into a blending tank to be uniformly mixed. According to the solid thickening agent for fracturing and the preparation method thereof, the shearing resistance, the temperature resistance, the salt resistance and the sand suspending property of the solid thickening agent are obviously superior to those of an existing thickening agent.

The invention belongs to the technical field of coatings, and provides an ionic bio-based polyester and a synthesis method thereof as well as an anti-fog coating and an application thereof aiming at the requirements of the current anti-fog coating on green and environment-friendly raw materials and the requirements of the current anti-fog coating on the environment-friendly property and simplicity of a coating production and coating process. The polyester synthesis method comprises the following steps: weighing dimethyl itaconate, dimethyl aliphatic diacid, aliphatic diol, tetrabutyl titanate and p-cresol, putting into a reaction container to obtain polyester containing carbon-carbon double bonds and proline choline ionic liquid, mixing the polyester containing carbon-carbon double bonds and proline choline ionic liquid in methanol to react to obtain ionic bio-based polyester, and reacting to obtain the ionic bio-based polyester. And mixing the ionic bio-based polyester with a photoinitiator and a solvent to prepare the anti-fog coating. Only one-time coating and ultraviolet curing are needed, the construction efficiency is improved, and the energy consumption and the time cost are reduced. Meanwhile, the coating obtained by the process has excellent optical performance and lasting anti-fog characteristic, is high in light transmittance, and can keep a clear and transparent visual effect of a substrate material for a long time.

The preparation method of bio-based non-isocyanate polyitaconamide urea belongs to the field of polymer synthesis and bio-based green materials. First, dimethyl itaconate is used to react with excess aliphatic diamine through Michael addition and intramolecular cyclization melt polycondensation, a rigid pyrrolidone heterocycle is introduced in situ in the main chain, and an amino-terminated itaconic acid polyamide prepolymer is formed. Subsequently, ethylene carbonate is used as a chain extender to carry out green bulk polymerization process without solvent and catalyst, and a strong hydrogen bonding non-isocyanate urea bond network is efficiently constructed. The present application ingeniously constructs a ternary synergistic system of "rigid heterocycle-strong hydrogen bond-long and short aliphatic chain", and the obtained material has excellent and comprehensive balanced performance.

The invention discloses environment-friendly unsaturated resin and a preparation method thereof, and belongs to the technical field of resin materials. The unsaturated resin is prepared from the following raw materials in parts by weight: 22 to 26 parts of polyethylene glycol terephthalate, 28 to 32 parts of dipropylene glycol, 14 to 18 parts of maleic anhydride, 2 to 4 parts of furan ring-containing dihydric alcohol, 2 to 4 parts of adipic acid, 2 to 3 parts of benzoic acid, 1 to 2 parts of glycerol, 18 to 22 parts of dimethyl itaconate, 1 to 3 parts of trimethylolpropane triacrylate, 2 to 4 parts of polyethylene glycol diacrylate, 0.5 to 2 parts of bismaleimide and the like. The preparation method comprises the following steps: introducing a furan group into polyester synthesis, cooling, and sequentially adding a mixed crosslinking agent and bismaleimide for pre-crosslinking. The resin not only has excellent mechanical properties, is green and environment-friendly, but also has heat-initiated self-repairing capability and recoverability and reprocessability, and widens the application of the resin in the field of high-end composite materials.

The present application belongs to the technical field of coating, aiming at the demand of raw material green environmental protection of current anti-fog coating, and the requirement of environmental protection and simplicity of coating production and coating process, an ionic biological based polyester and its synthesis method, anti-fog coating and its application are provided, the polyester synthesis method comprises the following steps: taking itaconic acid dimethyl ester, aliphatic diacid dimethyl ester, aliphatic diol, tetrabutyl titanate and p-cresol into a reaction container to obtain a polyester containing carbon-carbon double bond, and obtain proline choline ionic liquid, the two are mixed and reacted in methanol to obtain ionic biological based polyester, and the ionic biological based polyester is mixed with a photoinitiator and a solvent to prepare an anti-fog coating. The present application only needs one coating and ultraviolet curing, which improves the construction efficiency and reduces the energy consumption and time cost. At the same time, the coating obtained by the process has excellent optical performance and persistent anti-fog characteristics, high light transmittance, and can long-term maintain the visual effect of clear and transparent substrate material.