Construction method of double-disease model mouse
A technology of disease model and construction method, applied in the field of construction of double-disease model mice, can solve the problems of prone to complications, high operator requirements, associated with Parkinson's disease, etc., and achieves long stabilization time and high success rate. , the effect of easy detection
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[0027] 1. NOD / LtJ Mice mice were purchased from Wu's Experimental Animals (http: / / www.wssydw.com), 3 weeks old female mice were randomly divided into 3 groups: blank control group, MFB mechanical injury group (positive control group) ), drinking water group (experimental group), 12 rats in each group, adaptive feeding for one week, and the formal experiment started on day 28. Dimethyl itaconate was purchased from Shanghai Yien Chemical Technology Co., Ltd. (product number: R000622-25g, content: 98%).
[0028] 2. Preparation method of MFB mechanical injury model group: After being accurately fixed on the brain stereotaxic instrument, use a wire knife to go deep into the MFB site to cut it off; Drinking water group: 2 days / change water (containing 1.5mM itaconic acid di Methyl ester), the time is 15-20 days, individual differences are slightly different in different times; during the period of spontaneous type 1 diabetes, strengthen drinking water (once a week, for 2 days, until...
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