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Application of dimethyl itaconate in preparation of medicine for preventing and/or treating obesity-induced intestinal micro ecological disorder

A technology of dimethyl itaconate and intestinal microecology is applied in the directions of drug combination, anti-infective drugs, pharmaceutical formulations, etc., to achieve the effect of maintaining integrity, reducing intestinal inflammation, and preventing intestinal microecological disorders.

Pending Publication Date: 2022-02-11
XUZHOU MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there is no report on the use of dimethyl itaconate for the prevention and / or treatment of obesity-induced intestinal dysbiosis

Method used

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  • Application of dimethyl itaconate in preparation of medicine for preventing and/or treating obesity-induced intestinal micro ecological disorder
  • Application of dimethyl itaconate in preparation of medicine for preventing and/or treating obesity-induced intestinal micro ecological disorder
  • Application of dimethyl itaconate in preparation of medicine for preventing and/or treating obesity-induced intestinal micro ecological disorder

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Embodiment Construction

[0036] Examples are further listed below to describe the present invention in detail. It should also be understood that the following examples are only used to further illustrate the present invention, and should not be construed as limiting the protection scope of the present invention. Some non-essential improvements and adjustments made by those skilled in the art according to the principles set forth in the present invention all belong to the present invention scope of protection. The specific process parameters and the like in the following examples are only examples of the appropriate range, that is, those skilled in the art can make a selection within the appropriate range through the description herein, and are not limited to the specific data exemplified below.

[0037] The test materials and methods used in the embodiments of the present invention are as follows:

[0038] It should be noted that the following experimental results refer to the corresponding drawings:...

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Abstract

The invention relates to an application of dimethyl itaconate in the preparation of a medicine for treating and / or preventing obesity-induced intestinal micro ecological disorder. Experiments prove that dimethyl itaconate can correct intestinal micro ecological imbalance of obese mice, reduce intestinal inflammation and maintain intestinal barrier integrity.

Description

technical field [0001] The invention relates to the application of dimethyl itaconate in the preparation of medicines for treating and / or preventing obesity-induced intestinal microecological disorders. Background technique [0002] Obesity is an epidemic and systemic metabolic disease that seriously endangers human health. The Lancet reported in 2016 that there are currently about 600 million obese people in the world. A large amount of evidence shows that obesity can not only significantly increase the risk of heart disease, cerebrovascular disease, diabetes, non-alcoholic fatty liver, hypertension, cancer and other diseases, Moreover, it can cause the decline of cognitive function, which is an important cause of cognitive dysfunction and Alzheimer's disease. Therefore, related diseases caused by obesity have become serious public health problems. [0003] Intestinal microecological balance is an important factor in maintaining human health. Long-term intake of high-fat...

Claims

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Application Information

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IPC IPC(8): A61K31/225A61P3/04A61P1/00A61P31/00
CPCA61K31/225A61P3/04A61P1/00A61P31/00
Inventor 于英华潘伟徐大祥杨晓莹吴佳诚赵进秀张鹏胡敏敏胡涛李梦迪
Owner XUZHOU MEDICAL UNIV
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