Flow layer physical design method based on sequence pair under continuous microfluidic biochip
A physical design and biochip technology, applied in biomolecular computers, biological models, computer-aided design, etc., can solve the problems of failure to consider non-congested areas at intersections of flow channels, low convergence quality, and insufficient consideration of wiring order, etc. problem, to achieve the effect of the physical design scheme of the flow layer
Pending Publication Date: 2021-12-17
FUZHOU UNIV
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[0004] However, in this work, the parameters of the simulated annealing algorithm used in the layout stage have a great influence on the final result, and there are problems such as slow convergence speed and low convergence quality.
In the wiring stage, the influence of the wiring order on the wiring results is only weakened
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[0029] The present invention will be further described below in conjunction with the accompanying drawings and embodiments.
[0030] Please refer to figure 1 , the present invention provides a kind of flow layer physical design method based on sequence pair under continuous microfluidic biochip, comprises the following steps:
[0031] Step S1: Based on the sequence pair representation method, the component layout solution is obtained through the discrete particle swarm optimization algorithm in the component layout stage;
[0032] Step S2: In the wiring stage, the Manhattan distance between the component pairs is used as a basis for considering the wiring order, and wiring is performed based on a negotiated wiring algorithm;
[0033] Step S3: Adjust the layout of the flow channel intersection area according to the feedback information of the wiring;
[0034] Step S4: Connecting the stage of component layout and flow channel wiring, and judging whether the result of flow lay...
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The invention relates to a flow layer physical design method based on a sequence pair under a continuous microfluidic biochip. The method comprises the following steps: S1, obtaining a component layout solution through a discrete particle swarm optimization algorithm in a component layout stage based on a sequence pair representation method; S2, taking the Manhattan distance between the assembly pairs as a consideration basis of a wiring sequence in a wiring stage, and carrying out wiring based on a negotiation wiring algorithm; S3, according to feedback information of wiring, carrying out layout adjustment on a flow channel intersection point area; and S4, joining the component layout and the flow channel wiring stage, judging whether the flow layer physical design result after layout adjustment is further optimized, if so, circulating the steps S3-S4, and if not, completing the flow layer physical design. A high-quality flow layer physical design scheme is finally obtained by taking optimization of the number of cross points of flow channels, the chip area and the length of the flow channels as targets.
Description
technical field [0001] The invention belongs to the technical field of computer-aided design of integrated circuits, and in particular relates to a flow layer physical design method based on sequence pairs under a continuous microfluidic biochip. Background technique [0002] In the past ten years, microfluidic biochips have attracted more and more researchers' attention due to their low reagent / sample consumption, low manufacturing cost, and high efficiency of biochemical reaction execution, and have been widely used in many fields. With the wide application of microfluidic biochips and the continuous development of research, more and more design challenges have been raised, and more new design optimization algorithms and processes are required. [0003] Microfluidic biochips can be mainly divided into digital microfluidic biochips and continuous microfluidic biochips. For the design process of continuous microfluidic biochip, it can be mainly divided into the following st...
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Login to View More IPC IPC(8): G06F30/39G06F30/25G06N3/00G06F113/08G06F115/12G06F119/14
CPCG06F30/39G06F30/25G06N3/006G06N3/002G06F2119/14G06F2113/08G06F2115/12
Inventor 刘耿耿黄鸿斌黄兴徐赛娟郭文忠陈国龙
Owner FUZHOU UNIV