A bladder cancer early screening model and its construction method, kit and using method

Abstract

The present application relates to the technical field of bladder cancer screening, and specifically discloses a bladder cancer early screening model, a construction method, a kit and a use method thereof. The construction method includes the following steps: S1, obtaining gDNA sequencing results and cfDNA sequencing results of healthy samples and cancer samples respectively; S2, processing according to the cfDNA sequencing results to obtain SNP / INDEL features; processing the gDNA sequencing results to obtain CNV features; The characteristics and CNV characteristics are classified, and the ROC curve is drawn; S3, establish a bladder cancer early screening model; the kit conducts bladder cancer screening based on the model. The kit of the present application has the advantage of accurate screening for bladder cancer.

Description

technical field [0001] The present application relates to the technical field of bladder cancer screening, and more particularly, to a bladder cancer early screening model and its construction method and kit. Background technique [0002] Bladder cancer is one of the common malignant tumors and the most common malignant tumor of the urinary system. Current methods of monitoring bladder cancer rely on repeated cystoscopy, biopsy, and imaging studies. Cystoscopy is currently regarded as the gold standard for bladder cancer diagnosis, but these procedures are time-consuming, expensive, less sensitive to carcinoma in situ, and may lead to complications such as urinary tract infection, urethral injury, and bladder injury. The needle biopsy method can be invasive to the tissue because it is highly invasive. Imaging examinations carry radiation damage, and these conventional examination methods will bring pain to patients. [0003] Bladder cancer is a common malignant tumor of t...

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