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Treatment of anti-depression drug-induced sexual dysfunction with apomorphine

A technology of antidepressants and apomorphine, which can be applied in diseases, drug combinations, drug delivery, etc., and can solve problems such as adverse side effects and sexual dysfunction

Inactive Publication Date: 2004-03-31
TAP PHARM PROD INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Antidepressants have many unwanted side effects, such as sexual dysfunction

Method used

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  • Treatment of anti-depression drug-induced sexual dysfunction with apomorphine

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0047] A crossover study of home trials of apomorphine in 1500 male patients. As shown in Table 1, of the 1500 patients, 47 were taking selective serotonin reuptake inhibitors.

[0048] SSRI medications taken

Number of patients taking medication

PROZAC

22

ZOLOFT

13

PAXIL

12

[0049] In this crossover study, a baseline period of 2-4 weeks was used for the subjects evaluated. Thereafter, during the initial four weeks of treatment, the subjects received either a placebo or apomorphine, but they were not told whether they were receiving the active drug. Doses are 2, 4, 5 or 6 mg. This initial treatment period is followed by a 24-96 hour washout period during which no drug is administered. This was followed by a second four-week treatment period in which subjects who had previously received apomorphine were given placebo, but subjects who had previously received placebo were given apomorphine. After taking a tablet of apom...

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PUM

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Abstract

A method for treating sexual dysfunction in a patient taking anti-depressant medication in need of such treatment comprising administering a therapeutically effective amount of apomorphine or a pharmaceutically acceptable salt thereof to said patient is disclosed. The method may be utilized for patients taking anti-depressants such as tricyclic anti-depressants, monamine oxidase inhibitors or serotonin selective reuptake inhibitors.

Description

field of invention [0001] The present invention relates to a method for treating sexual dysfunction in patients taking antidepressants, the method comprising administering a therapeutically effective amount of apomorphine or a pharmaceutically acceptable salt thereof to the patient in need of such treatment. This approach can be used in patients taking antidepressants, such as tricyclic antidepressants, monoamine oxidase inhibitors, or serotonin selective reuptake inhibitors. Background of the invention [0002] Depression is a chronic disease that affects people of all ages. Tricyclic antidepressants, monoamine oxidase inhibitors, and selective serotonin reuptake inhibitors are a few of the classes of drugs prescribed to treat depression. Tricyclic antidepressants include imipramine hydrochloride, imipramine pamoate, amitriptyline hydrochloride, desipramine hydrochloride, and protriptyline hydrochloride. Monoamine oxidase inhibitors include isocarbo...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D221/18A61K9/72A61K31/473A61K31/4745A61K31/485A61K45/00A61K45/06A61P1/08A61P15/10A61P25/24
CPCA61K31/4525A61K45/06A61K31/485A61K31/138A61K31/135A61K31/4745A61K31/473A61P1/08A61P15/00A61P15/10A61P25/00A61P25/24A61K2300/00
Inventor D·D·鲁夫R·J·佩尔多克
Owner TAP PHARM PROD INC
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