Platform for screening related gene by antisense nucleic acid technology and disease animal model

Abstract

A select technology for the gene referring to schizoid. The technology makes mouse with schizoid be as mode, combining with nucleic acid synthesis technology and animal behaviour test. It can be used for researching genetic function of desease and developing medicine.

Description

technical field [0001] The present invention relates to the fields of animal behavior and drug screening, more specifically, the present invention relates to a platform for screening disease-related genes using antisense nucleic acid technology and animal models, and a method for screening therapeutic drugs using the platform. Background technique [0002] Schizophrenia is one of the ten most disabling or incapacitating diseases in the world, and it is also the most prevalent among various mental diseases (Warner R, Girolamo D, Chengyi Renwang Keqin (translation). Spiritual Schizophrenia. World Health Organization, People's Medical Publishing House, 1997). The etiology of schizophrenia is unknown, and it has many obstacles such as perception, thinking, emotion and behavior, as well as incoordination of mental activities and symptoms of incoordination between mental activities and the environment (Diagnostic and Statistical and Manual of Mental Disorders, 3rd ed.Washington, D...

AI Technical Summary

Problems solved by technology

[0004] However, this approach has significant drawbacks: (a) the number of samples is limited, so candidate genes cannot be effectively identified

[0005] In summary, for many diseases such as mental illness, there is a long-term lack of effective and accurate methods for determining disease (such as mental illness)-related genes in this field.

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