Platform for screening related gene by antisense nucleic acid technology and disease animal model

An antisense nucleic acid and candidate gene technology, applied in the field of animal behavior and drug screening, can solve the problems of inability to effectively determine candidate genes, lack, limited number of samples, etc.

Inactive Publication Date: 2005-10-12
上海中科伍佰豪生物工程有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] However, this approach has significant drawbacks: (a) the number of samples is limited, so candidate genes cannot be effectively identified
[0005] In summary, for many diseases such as mental illness, there is a long-term lack of effective and accurate methods for determining disease (such as mental illness)-related genes in this field.

Method used

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  • Platform for screening related gene by antisense nucleic acid technology and disease animal model
  • Platform for screening related gene by antisense nucleic acid technology and disease animal model
  • Platform for screening related gene by antisense nucleic acid technology and disease animal model

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0055] Materials and Methods

[0056] 1 Material:

[0057] 1.1 Preparation of reagents and solutions

[0058] Gene A

sequence

SEQ ID NO:

antisense nucleic acid fragment

gtc ccg ggt ttt tca ccc at

1

missense nucleic acid fragment

gtc ccg gct tta tct cgc at

2

Gene S

sequence

SEQ ID NO:

antisense nucleic acid fragment

ctg tgg tcc ata ata gac at

3

missense nucleic acid fragment

ctg tcg tgc att aaa gtc at

4

Gene N

sequence

SEQ ID NO:

antisense nucleic acid fragment

ccc atc tct ggg tct gac at

5

missense nucleic acid fragment

ccg atc tgt cgg act ctc at

6

[0059] 1.2 Experimental animals Inbred BALB / c mice, all male, weighing (20±2g), SPF grade, were purchased from the Experimental Animal Center of Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences. Experimental animal production license numb...

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PUM

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Abstract

A select technology for the gene referring to schizoid. The technology makes mouse with schizoid be as mode, combining with nucleic acid synthesis technology and animal behaviour test. It can be used for researching genetic function of desease and developing medicine.

Description

technical field [0001] The present invention relates to the fields of animal behavior and drug screening, more specifically, the present invention relates to a platform for screening disease-related genes using antisense nucleic acid technology and animal models, and a method for screening therapeutic drugs using the platform. Background technique [0002] Schizophrenia is one of the ten most disabling or incapacitating diseases in the world, and it is also the most prevalent among various mental diseases (Warner R, Girolamo D, Chengyi Renwang Keqin (translation). Spiritual Schizophrenia. World Health Organization, People's Medical Publishing House, 1997). The etiology of schizophrenia is unknown, and it has many obstacles such as perception, thinking, emotion and behavior, as well as incoordination of mental activities and symptoms of incoordination between mental activities and the environment (Diagnostic and Statistical and Manual of Mental Disorders, 3rd ed.Washington, D...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K49/00C12Q1/68
Inventor 金玫蕾丁澄邹洪周雪东谢青莲赵国屏于雷
Owner 上海中科伍佰豪生物工程有限公司
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