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NGF antagonist and opioid analgesic use in pain treatment

An antagonist, opioid technology, applied in the field of NGF antagonists and opioid agents in the treatment of pain, can solve problems such as limiting clinical use

Active Publication Date: 2006-12-13
RINAT NEUROSCI CORP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Another undesirable property is the development of tolerance and physical dependence, which limit the clinical use of this class of compounds

Method used

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  • NGF antagonist and opioid analgesic use in pain treatment
  • NGF antagonist and opioid analgesic use in pain treatment
  • NGF antagonist and opioid analgesic use in pain treatment

Examples

Experimental program
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Effect test

Embodiment 1

[0188] Anti-NGF monoclonal antibody combined with opioid analgesics for postoperative pain

[0189] We evaluated the efficacy of an anti-NGF antibody in combination with an opioid analgesic (morphine) using a pain model that mimics postoperative pain. Each experiment included 16 animals (n=8 / group).

[0190] animal. For each experiment, 16 male adult Sprague Dawley rats (Harlan; Indianapolis, IN) weighing 200-220 g were housed under normal light conditions for at least one week prior to use with food and water ad libitum.

[0191] On the day before the operation, after acclimatizing the rats in the experimental cage for 2 hours, the rats were divided into two groups: one group received the antibody 15 hours before the operation, and the other group received the vehicle (5% glucose / 0.45 % saline USP). Anti-NGF antagonist antibody Mab 911 (see Hongo, et al., Hybridoma 19:215-227 (2000)) was administered intraperitoneally (i.p.) at a concentration of 0.3-20 mg / kg. Twenty-four...

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Abstract

The present invention features methods for treating or preventing pain comprising administering an amount of a nerve growth factor antagonist and an amount of an opioid analgesic such that together they provide effective pain relief. The invention also features compositions comprising a nerve growth factor antagonist and an opioid analgesic and kits containing the same.

Description

[0001] Cross references to related applications [0002] This application claims the benefit of priority to US Provisional Patent Application Serial No. 60 / 417,347, filed October 8, 2002, the contents of which are incorporated by reference in their entirety. [0003] Statement Regarding Federally Sponsored Research or Development [0004] This invention was made with United States Government support through DARPA under Contract No. DAAD19-03-C-0006. The US Government may have certain rights in this invention. field of invention [0005] The present invention relates to methods and compositions for preventing or treating pain in a patient by administering a nerve growth factor antagonist in combination with an opioid analgesic. Background of the invention [0006] Severe pain is often treated with opioid analgesics, which unfortunately have many adverse side effects, including decreased gastric motility, renal col...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07K16/22A61K31/485
CPCC07K16/22A61K2039/505A61K39/3955A61K31/485C07K2317/76A61P25/04A61K2300/00A61K39/395
Inventor D·L·谢尔顿G·J·韦尔加拉
Owner RINAT NEUROSCI CORP
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