Integrated cleaning and measuring mechanism

Abstract

The utility model relates to an integrated cleaning and measuring mechanism which comprises a box body, a plurality of magnets, a turntable driving part, a turntable, a photomultiplier tube, an upper cover, a fixing frame, a plurality of waste liquid extraction parts, a liquid extraction needle driving part and a plurality of liquid injection parts. An opening is formed in the circle center of the bottom of the box body, a circular groove is formed in the bottom of the box body, and a plurality of magnet grooves distributed at intervals are formed in the inner side and the outer side of the circular groove respectively; the lower end of an opening of the turntable is connected with a reaction cup accommodating cavity; the photomultiplier is arranged at the daylighting opening of the box body; the upper cover is provided with a grabbing and releasing opening and a plurality of open holes distributed at intervals in the circumferential direction. The fixing frame is fixed on the upper cover; the multiple waste liquid extraction parts are arranged on the fixing frame at intervals in the circumferential direction, and liquid extraction needles of the waste liquid extraction parts correspond to the holes of the upper cover; and the plurality of liquid injection parts are arranged at the plurality of holes of the upper cover. According to the structure, cleaning, separating and measuring are integrated, the occupied space is small, operation is convenient, and the experiment efficiency is greatly improved.

Description

Technical Field

[0001] The utility model relates to the field of medical equipment, in particular to an integrated cleaning and measuring mechanism. Background Art

[0002] In the fully automatic immunoassay system, the effective separation of immune complexes is the key link of immunoassay, and the separation effect directly affects the results of immunoassay. Usually, the cleaning and separation disk and the measuring disk are designed separately in the chemiluminescence instrument. The cleaning and separation are performed first, and then the reaction cup is grabbed from the cleaning and separation disk to the measuring disk for measurement by a mechanical gripper.

[0003] However, in a small chemiluminescence instrument, due to the small and compact space, it is impossible to design each component separately like a large machine. Therefore, it is necessary to design a device that can integrate cleaning and measurement into one. Utility Model Content

[0004] In order to solve the above technical problems, the utility model provides the following technical solutions:

[0005] An integrated cleaning measurement mechanism, comprising:

[0006] A box body, the box body is formed in a cylindrical shape, an opening is formed at the center of the bottom of the box body, a circular groove is formed at the bottom of the box body, the center of the circular groove is the center of the box body, a plurality of magnet grooves arranged at intervals are formed on the inner side and the outer side of the circular groove, and a light-collecting opening is formed on the side of the box body, and the light-collecting opening is connected to the circular groove;

[0007] A plurality of magnets, wherein the plurality of magnets are respectively fixed in the plurality of magnet slots;

[0008] A turntable driving unit, the turntable driving unit is connected to the box body;

[0009] A turntable, the turntable is connected to the turntable driving unit through the opening at the bottom of the box body, a plurality of openings arranged at intervals along the circumferential direction are formed on the turntable, a reaction cup accommodating cavity is connected to the lower end of the opening of the turntable, and the reaction cup accommodating cavity is located in the circular groove;

[0010] A photomultiplier tube, wherein the photomultiplier tube is arranged at the light-collecting opening of the box;

[0011] An upper cover, the upper cover covers the box body, and the upper cover is formed with a gripping opening and a plurality of openings spaced apart along the circumferential direction at a position corresponding to the circular groove;

[0012] A fixing frame, wherein the fixing frame is fixed on the upper cover;

[0013] A plurality of waste liquid extraction parts, wherein the plurality of waste liquid extraction parts are arranged on the fixing frame at intervals along the circumferential direction, and the extraction needles of the waste liquid extraction parts correspond to the openings of the upper cover;

[0014] A liquid extraction needle driving unit, which is arranged on the fixing frame and is used to drive the liquid extraction needle to move up and down;

[0015] A plurality of liquid injection parts are provided at a plurality of openings of the upper cover, and the plurality of liquid injection parts are cross-arranged with the plurality of waste liquid extraction parts.

[0016] Preferably, a plurality of return edge structures are provided between the upper cover, the turntable and the box body.

[0017] Preferably, the magnet grooves on the outer side of the circular groove are arranged crosswise with the magnet grooves on the inner side.

[0018] Preferably, the turntable driving unit comprises:

[0019] A driving motor connected to a side wall of the box;

[0020] A driving wheel, the driving wheel is connected to a driving shaft of the driving motor;

[0021] A connecting shaft, the upper end of which is connected to the turntable, and the other end of which extends out of the opening at the bottom of the box;

[0022] A driven wheel connected to the lower end of the connecting shaft;

[0023] A conveyor belt is connected to the driving wheel and the driven wheel.

[0024] Preferably, a limiting step is formed at the bottom of the magnet slot, and a limiting slot matching the limiting step is formed at the bottom of the magnet.

[0025] Preferably, the integrated cleaning measurement mechanism further includes:

[0026] A plurality of pressing blocks are respectively placed between the magnet and the turntable.

[0027] Preferably, the integrated cleaning measurement mechanism further includes:

[0028] A top screw, a screw hole is formed on the pressing block, and the top screw is located in the screw hole and abuts against the magnet.

[0029] Preferably, the integrated cleaning measurement mechanism further includes:

[0030] A plurality of pressing plates are provided between the top wire and the magnet.

[0031] Preferably, the fixing frame comprises:

[0032] A plurality of columns, wherein the lower ends of the plurality of columns are fixed on the upper cover;

[0033] A fixing plate is fixed on the upper ends of the plurality of columns, and the waste liquid extraction part and the liquid extraction needle driving part are arranged on the fixing plate.

[0034] Preferably, the integrated cleaning measurement mechanism further includes:

[0035] A plurality of bases are fixed on the bottom of the box.

[0036] The utility model has at least the following beneficial effects:

[0037] The integrated cleaning and measuring mechanism of this embodiment directly fixes the photomultiplier tube for measurement to the side of the cleaning part. After the reaction cup enters the interior of the component, it is processed in sequence by multiple stations such as magnetic focusing, cleaning and separation, substrate addition, measurement, solid-liquid separation, etc., and then is grabbed and discarded by the robot. This structure integrates cleaning and separation with measurement, takes up less space, is easy to operate, and greatly improves the experimental efficiency.

[0038] In order to reduce the timing action within the component, a normally open design is adopted at the component grab and place cup position, without the need for an additional switch door structure.

[0039] In the installation and fixation of the magnet, considering that the magnet should not be directly tightened with a top screw, a pressing piece is used to contact the magnet, a screw hole is opened on the pressing block, and a top screw is used to push it onto the pressing piece, thereby protecting the magnet.

[0040] The magnet layout adopts an "inside-outside cross" layout, which ensures a good magnetic focusing effect while achieving the effect of magnetic beads swimming inside the reaction cup, and can thoroughly clean the reaction residues that may be wrapped by the magnetic beads. BRIEF DESCRIPTION OF THE DRAWINGS

[0041] Figure 1 A structural schematic diagram of an integrated cleaning and measuring mechanism according to an embodiment of the utility model;

[0042] Figure 2 It is another structural schematic diagram of the integrated cleaning and measuring mechanism of one embodiment of the utility model;

[0043] Figure 3 It is a cross-sectional view of an integrated cleaning and measuring mechanism according to an embodiment of the utility model;

[0044] Figure 4 It is a cross-sectional view of an integrated cleaning and measuring mechanism according to an embodiment of the utility model;

[0045] Figure 5This is a schematic structural diagram of a turntable of an integrated cleaning and measuring mechanism according to an embodiment of the utility model;

[0046] Figure 6 A cross-sectional view of the light-collecting port of the integrated cleaning and measuring mechanism according to an embodiment of the utility model;

[0047] Figure 7 A cross-sectional view of a magnet slot of an integrated cleaning and measuring mechanism according to an embodiment of the present utility model;

[0048] Figure 8 A top view of an integrated cleaning and measuring mechanism according to an embodiment of the utility model;

[0049] Fig. 9 A top view of a box body of an integrated cleaning and measuring mechanism according to an embodiment of the utility model;

[0050] Figure numerals: 1. housing; 2. magnet; 3. turntable drive unit; 4. turntable; 5. photomultiplier tube; 6. upper cover; 7. fixing frame; 8. waste liquid extraction unit; 9. extraction needle drive unit; 10. liquid injection unit; 11. circular groove; 12. magnet groove; 13. light-collecting port; 14. reaction cup accommodating cavity; 15. grab and release port; 16. extraction needle; 17. reaction cup; 18. return edge structure; 19. driving motor; 20. driving wheel; 21. connecting shaft; 22. driven wheel; 23. conveyor belt; 24. limiting step; 25. pressure block; 26. top screw; 27. pressure sheet; 28. column; 29. ​​fixing plate; 30. base. DETAILED DESCRIPTION

[0051] In order to make the purpose, technical solution and advantages of the embodiment of the utility model clearer, the technical solution of the embodiment of the utility model will be clearly and completely described below in conjunction with the drawings of the embodiment of the utility model. Obviously, the described embodiment is a part of the embodiment of the utility model, not all of the embodiments. Based on the described embodiment of the utility model, all other embodiments obtained by ordinary technicians in this field belong to the scope of protection of the utility model.

[0052] Unless otherwise defined, the technical terms or scientific terms used in the present invention shall have the usual meanings understood by persons with ordinary skills in the field to which the present invention belongs. The words "first", "second" and similar words used in the present invention do not indicate any order, quantity or importance, but are only used to distinguish different components. Similarly, words such as "one" or "one" do not indicate quantity restrictions, but indicate the existence of at least one. Words such as "connect" or "connected" are not limited to physical or mechanical connections, but may include electrical connections, whether direct or indirect. "Up", "down", "left", "right" and the like are only used to indicate relative positional relationships. When the absolute position of the object being described changes, the relative positional relationship also changes accordingly.

[0053] The embodiments of the present utility model are described in detail below in conjunction with the accompanying drawings.

[0054] like Figure 1-9 As shown, an embodiment of the utility model provides an integrated cleaning and measuring mechanism, including a housing 1, a plurality of magnets 2, a turntable drive unit 3, a turntable 4, a photomultiplier tube 5, an upper cover 6, a fixing frame 7, a plurality of waste liquid extraction units 8, a liquid extraction needle drive unit 9, and a plurality of liquid injection units 10. The housing 1 is formed in a cylindrical shape, with an opening formed at the center of the bottom of the housing 1, a circular groove 11 formed at the bottom of the housing 1, the center of the circular groove 11 being the center of the housing 1, a plurality of magnet grooves 12 arranged at intervals are formed on the inner and outer sides of the circular groove 11, respectively, a light-collecting opening 13 is formed on the side of the housing 1, and the light-collecting opening 13 is connected to the circular groove 11; a plurality of magnets 2 are respectively fixed in the plurality of magnet grooves 12; the turntable drive unit 3 is connected to the housing 1; the turntable 4 is connected to the turntable drive unit 3 through the opening at the bottom of the housing 1, a plurality of openings arranged at intervals along the circumferential direction are formed on the turntable 4, and a reaction cup accommodating cavity 14 is connected to the lower end of the opening of the turntable 4, The reaction cup accommodating cavity 14 is located in the circular groove 11; the photomultiplier tube 5 is arranged at the light-collecting port 13 of the housing 1; the upper cover 6 covers the housing 1, and the upper cover 6 is formed with a grabbing and releasing port 15 and a plurality of openings arranged at intervals along the circumferential direction at the position corresponding to the circular groove 11; the fixing frame 7 is fixed on the upper cover 6; a plurality of waste liquid extraction parts 8 are arranged on the fixing frame 7 at intervals along the circumferential direction, and the liquid extraction needles 16 of the waste liquid extraction parts 8 correspond to the openings of the upper cover 6; the liquid extraction needle driving part 9 is arranged on the fixing frame 7, and is used to drive the liquid extraction needle 16 to move up and down; a plurality of liquid injection parts 10 are arranged at a plurality of openings of the upper cover 6, and the plurality of liquid injection parts 10 are arranged crosswise with the plurality of waste liquid extraction parts 8.

[0055] The operation process of the integrated cleaning and measuring mechanism of this embodiment is as follows: a reaction cup 17 containing magnetic beads is placed into a reaction cup accommodating cavity 14 under the grabbing and releasing port 15 by a manipulator, and the turntable driving unit 3 drives the turntable 4 to rotate; during the rotation process, when the reaction cup 17 passes through the liquid injection unit 10, the liquid injection unit 10 injects liquid into it, and when it passes through the waste liquid extraction unit 8, the liquid extraction needle driving unit 9 drives the liquid extraction needle 16 to descend into the reaction cup 17, extract the liquid therein, and then rise to the outside of the reaction cup 17; during the rotation of the turntable 4, the magnets 2 on both sides of the reaction cup 17 will drive the magnetic beads to move back and forth, thereby playing a stirring role; then the substrate is added through the liquid injection unit 10, and then the reaction cup 17 is measured by the photomultiplier tube 5 at the light-collecting port 13; finally, the substrate is extracted and the reaction cup 17 is taken out and discarded.

[0056] The integrated cleaning and measuring mechanism of this embodiment directly fixes the photomultiplier tube 5 for measurement to the side of the cleaning part. After the reaction cup 17 enters the interior of the component, it is processed in sequence by multiple stations such as magnetic focusing, cleaning and separation, substrate addition, measurement, solid-liquid separation, etc., and then is grabbed and discarded by the robot. This structure integrates cleaning and separation with measurement, takes up less space, is easy to operate, and greatly improves the experimental efficiency. In addition, in order to reduce the timing action in the component, a normally open design is adopted at the component grab and release cup position, and no additional switch door structure is required.

[0057] In this embodiment, multiple return edge structures 18 are provided between the upper cover 6, the turntable 4, and the housing 1. A concave-convex return edge design is adopted between each other, and a certain gap is left to ensure that the rotation of the internal turntable 4 can be achieved and the measurement position can be well shielded from light. The gap amount is usually controlled at about 0.5 mm. In addition, the holes of the turntable 4 are isolated from each other in the circumferential direction, and a small gap of about 0.5 mm is maintained with the housing 1 in the diameter direction to avoid light interference between the reaction cups 17.

[0058] In this embodiment, the magnet groove 12 outside the circular groove 11 is arranged crosswise with the magnet groove 12 inside the circular groove 11. The layout of the magnet 2 adopts an "inside-outside cross" layout, which ensures a good magnetic concentration effect while achieving the effect of magnetic beads swimming inside the reaction cup 17, and can thoroughly clean the reaction residues that may be wrapped by the magnetic beads.

[0059] In this embodiment, the turntable driving unit 3 includes a driving motor 19, a driving wheel 20, a connecting shaft 21, a driven wheel 22, and a conveyor belt 23. The driving motor 19 is connected to the side wall of the box body 1; the driving wheel 20 is connected to the driving shaft of the driving motor 19; the upper end of the connecting shaft 21 is connected to the turntable 4, and the other end extends out of the opening at the bottom of the box body 1; the driven wheel 22 is connected to the lower end of the connecting shaft 21; and the conveyor belt 23 connects the driving wheel 20 and the driven wheel 22.

[0060] In this embodiment, a limiting step 24 is formed at the bottom of the magnet slot 12 , and a limiting groove matching the limiting step 24 is formed at the bottom of the magnet 2 to fix the position of the magnet 2 .

[0061] In this embodiment, the integrated cleaning and measuring mechanism further includes a plurality of pressing blocks 25. The plurality of pressing blocks 25 are respectively placed between the magnet 2 and the rotating disk 4 to press the magnet 2 to prevent it from loosening.

[0062] In this embodiment, the integrated cleaning and measuring mechanism further includes a top screw 26. A screw hole is formed on the pressing block 25, and the top screw 26 is located in the screw hole and abuts against the magnet 2. In the installation and fixing of the magnet 2, considering that the magnet 2 should not be directly tightened by the top screw 26, a pressing sheet 27 is used to contact the magnet 2, a screw hole is opened from the pressing block 25, and the top screw 26 is used to press against the pressing sheet 27, thereby protecting the magnet 2.

[0063] In this embodiment, the fixing frame 7 includes a plurality of columns 28 and a fixing plate 29. The lower ends of the plurality of columns 28 are fixed to the upper cover 6; the fixing plate 29 is fixed to the upper ends of the plurality of columns 28, and the waste liquid extraction part 8 and the liquid extraction needle driving part 9 are arranged on the fixing plate 29.

[0064] In this embodiment, the integrated cleaning and measuring mechanism further includes a plurality of bases 30. The plurality of bases 30 are fixed to the bottom of the box body 1.

[0065] The above embodiments are used to further illustrate the present invention, but the present invention is not limited to these specific implementations. Any modification, equivalent replacement and improvement made within the spirit and principle of the present invention should be understood to be within the protection scope of the present invention.

Claims

1. An integrated cleaning and measuring mechanism, characterized in that: include: A box body (1), the box body (1) is formed in a cylindrical shape, an opening is formed at the center of the bottom of the box body (1), a circular groove (11) is formed at the bottom of the box body (1), the center of the circular groove (11) is the center of the box body (1), a plurality of magnet grooves (12) arranged at intervals are formed on the inner side and the outer side of the circular groove (11), and a light-collecting opening (13) is formed on the side of the box body (1), and the light-collecting opening (13) is connected to the circular groove (11); A plurality of magnets (2), wherein the plurality of magnets (2) are respectively fixed in the plurality of magnet slots (12); A turntable driving unit (3), wherein the turntable driving unit (3) is connected to the box (1); a turntable (4), the turntable (4) being connected to the turntable driving unit (3) via an opening at the bottom of the housing (1), the turntable (4) being formed with a plurality of openings arranged at intervals along the circumferential direction, the lower end of the opening of the turntable (4) being connected to a reaction cup accommodating cavity (14), the reaction cup accommodating cavity (14) being located in the circular groove (11); A photomultiplier tube (5), wherein the photomultiplier tube (5) is arranged at a light-collecting opening (13) of the housing (1); An upper cover (6), the upper cover (6) covering the box body (1), the upper cover (6) being formed with a gripping and releasing opening (15) and a plurality of openings spaced apart along the circumferential direction at a position corresponding to the circular groove (11); A fixing frame (7), wherein the fixing frame (7) is fixed on the upper cover (6); A plurality of waste liquid extraction parts (8), wherein the plurality of waste liquid extraction parts (8) are arranged on the fixing frame (7) at intervals along the circumferential direction, and the extraction needles (16) of the waste liquid extraction parts (8) correspond to the openings of the upper cover (6); A liquid extraction needle driving unit (9), the liquid extraction needle driving unit (9) being arranged on the fixing frame (7) and used for driving the liquid extraction needle (16) to move up and down; A plurality of liquid injection parts (10), wherein the plurality of liquid injection parts (10) are arranged at a plurality of openings of the upper cover (6), and the plurality of liquid injection parts (10) and the plurality of waste liquid extraction parts (8) are arranged crosswise.

2. The integrated cleaning and measuring mechanism according to claim 1, characterized in that: A plurality of return edge structures (18) are arranged between the upper cover (6), the turntable (4) and the box body (1).

3. The integrated cleaning and measuring mechanism according to claim 1, characterized in that: The magnet groove (12) outside the circular groove (11) and the magnet groove (12) inside the circular groove (11) are arranged crosswise.

4. The integrated cleaning and measuring mechanism according to claim 1, characterized in that: The turntable driving unit (3) comprises: A driving motor (19), wherein the driving motor (19) is connected to a side wall of the box body (1); A driving wheel (20), wherein the driving wheel (20) is connected to a driving shaft of the driving motor (19); A connecting shaft (21), the upper end of which is connected to the turntable (4), and the other end of which extends out of the opening at the bottom of the box body (1); A driven wheel (22), the driven wheel (22) being connected to the lower end of the connecting shaft (21); A conveyor belt (23), wherein the conveyor belt (23) connects the driving wheel (20) and the driven wheel (22).

5. The integrated cleaning and measuring mechanism according to claim 1, characterized in that: A limiting step (24) is formed at the bottom of the magnet slot (12), and a limiting slot matching the limiting step (24) is formed at the bottom of the magnet (2).

6. The integrated cleaning and measuring mechanism according to claim 1, characterized in that: Also includes: A plurality of pressing blocks (25), wherein the plurality of pressing blocks (25) are respectively placed between the magnet (2) and the turntable (4).

7. The integrated cleaning and measuring mechanism according to claim 6, characterized in that: Also includes: A top screw (26), wherein a screw hole is formed on the pressing block (25), and the top screw (26) is located in the screw hole and abuts against the magnet (2).

8. The integrated cleaning and measuring mechanism according to claim 7, characterized in that: Also includes: A plurality of pressing sheets (27), wherein the pressing sheets (27) are arranged between the top wire (26) and the magnet (2).

9. The integrated cleaning and measuring mechanism according to claim 1, characterized in that: The fixing frame (7) comprises: A plurality of upright posts (28), wherein the lower ends of the plurality of upright posts (28) are fixed on the upper cover (6); A fixed plate (29), wherein the fixed plate (29) is fixed to the upper ends of the plurality of upright columns (28), and the waste liquid extraction unit (8) and the liquid extraction needle driving unit (9) are arranged on the fixed plate (29).

10. The integrated cleaning and measuring mechanism according to claim 1, characterized in that: Also includes: A plurality of bases (30), wherein the plurality of bases (30) are fixed on the bottom of the box body (1).

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