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Composition for treating or preventing glaucoma comprising a sulfonamide compound and another drug

a technology of sulfonamide and sulfonamide, which is applied in the direction of organic active ingredients, pharmaceutical active ingredients, organic chemistry, etc., can solve the problem that it is not known at all what effect such a combination exerts on intraocular pressure, and achieve the effect of enhancing the effect of intraocular pressure lowering

Inactive Publication Date: 2016-08-11
SANTEN PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

The invention is a combination of isopropyl (6-{[4-(pyrazol-1-yl)benzyl](pyridin-3-ylsulfonyl) aminomethyl}pyridin-2-ylamino)acetate and one or more other preventive or therapeutic drugs for glaucoma or ocular hypertension. This combination can lower intraocular pressure and is useful as a preventive or therapeutic agent for glaucoma or ocular hypertension or an intraocular pressure lowering agent.

Problems solved by technology

However, there have been no reports specifically disclosing a combination of isopropyl (6-{[4-(pyrazol-1-yl)benzyl](pyridin-3-ylsulfonyl) aminomethyl}pyridin-2-ylamino)acetate, which has a high EP2 receptor selectivity and a potent EP2 agonistic activity, with other preventive or therapeutic drug for glaucoma or ocular hypertension, and naturally, it has not been known at all as to what effect of such a combination is exerted on the intraocular pressure.

Method used

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  • Composition for treating or preventing glaucoma comprising a sulfonamide compound and another drug

Examples

Experimental program
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preparation examples

[0056]Hereinafter, specific preparation examples of an eye drop and an ophthalmic ointment containing the present compound and the other preventive or therapeutic drug for glaucoma or ocular hypertension according to the invention will be shown.

preparation example 1

[0057]

Eye Drop (in 100 mL)Present compound0.01 gDipivefrin hydrochloride0.04 gSodium dihydrogen phosphate0.15 gGlycerinq.s.Polyoxyl 35 castor oil 1.7 gDisodium edetate0.05 gBenzalkonium chloride0.005 g Diluted hydrochloric acidq.s.Sodium hydroxideq.s.Purified waterq.s.

preparation example 2

[0058]

Eye Drop (in 100 mL)Present compound0.01 gTimolol maleate0.25 gSodium dihydrogen phosphate0.15 gGlycerinq.s.Polyoxyl 35 castor oil 1.7 gDisodium edetate0.05 gBenzalkonium chloride0.005 g Diluted hydrochloric acidq.s.Sodium hydroxideq.s.Purified waterq.s.

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Abstract

A composition for preventing or treating glaucoma or ocular hypertension including a combination of isopropyl (6-{[4-(pyrazol-1-yl)benzyl](pyridin-3-ylsulfonyl)aminomethyl} pyridin-2-ylamino) acetate and at least one other drug for preventing or treating glaucoma or ocular hypertension, with the proviso that tafluprost is excluded.

Description

CROSS-REFERENCE TO RELATED APPLICATIONS[0001]This application is a Continuation application of application Ser. No. 13 / 939,381 filed on Jul. 11, 2013. This application also claims the benefit of U.S. Provisional Application No. 61 / 671,219 filed Jul. 13, 2012. The entire contents of application Ser. No. 13 / 939,381 and Provisional Application No. 61 / 671,219 are incorporated by reference herein.TECHNICAL FIELD[0002]The present invention relates to a preventive or therapeutic agent for glaucoma or ocular hypertension, or an intraocular pressure lowering agent comprising a combination of isopropyl (6-{[4-(pyrazol-1-yl) benzyl] (pyridin-3-ylsulfonyl) aminomethyl}pyridin-2-ylamino) acetate with other preventive or therapeutic drug for glaucoma or ocular hypertension.BACKGROUND ART[0003]Glaucoma is an intractable ocular disease with a risk of blindness, involving an increase in intraocular pressure due to various predisposing factors and the disorder of internal tissues of eyeballs (retina,...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): A61K31/444A61K31/551A61K31/542A61K31/5377A61K31/5575A61K31/498A61K31/225A61K31/4178
CPCA61K31/444A61K31/551A61K45/06A61K31/498A61K31/5377A61K31/542A61K31/5575C07D401/14A61K31/225A61K31/4178A61K2300/00
Inventor KIRIHARA, TOMOKOSHIMAZAKI, ATSUSHINAKAMURA, MASATSUGU
Owner SANTEN PHARMA CO LTD
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